专利号:US-8304532-B2 优先权日:2002-07-31 标 题:Method for preparing oligonucleotides 发明人:ADAMO ILARIA; DUEYMES CECILE; SCHONBERGER ANDREAS; IMBACH JEAN-LOUIS; MEYER ALBERT; MORVAN FRANCOIS; DEBART FRANCOISE; VASSEUR JEAN-JACQUES; LANGE MEINOLF; LINK FRITZ 权利人:ADAMO ILARIA; DUEYMES CECILE; SCHONBERGER ANDREAS; IMBACH JEAN-LOUIS; MEYER ALBERT; MORVAN FRANCOIS; DEBART FRANCOISE; VASSEUR JEAN-JACQUES; LANGE MEINOLF; LINK FRITZ; GIRINDUS AG; CENTRE NAT RECH SCIENT; UNIV MONTPELLIER II 摘要:A solution phase synthesis method for preparing an oligonucleotide, wherein at least some of the reagents are solid supported. The method suitable for large-scale synthesis comprises coupling a protected compound with a nucleotide derivative having a protection group in the presence of a solid supported activator to give an elongated oligonucleotide with a P(III)-internucleotide bond; optionally processing the elongated oligonucleotide by capping by reaction with a solid supported capping agent and/or by oxidizing or sulfurizing by reaction of the oligonucleotide with a solid supported oxidizing or sulfurization reagent; and removing the protection group. The coupling may include reacting a 3′-protected compound of formula: n nwith a nucleotide derivative having a 5′-protection group, or reacting a 5′-protected compound of formulan n nwith a nucleotide derivative having a 3′-protection group.
专利号:US-4273578-A 优先权日:1979-03-22 标题 :Method for recovering rhodium 发明人:NESVADBA PAUL; WEIGL GISELA 权利人:HERAEUS GMBH W C 摘要:A method for recovering rhodium from a residue of the oxo synthesis or of a hydroformylation which comprises contracting said residue with sulfur and separating and converting the resultant rhodium-containing precipitate to rhodium or a rhodium compound in a manner known per se.
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合成参考文献
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