CAS: 156053-89-3; Alvimopan

上下游产品

CAS号20593-63-9 ethyl 2-benzyla... | CAS号119193-19-0 (3R,4R)-3,4-二甲基... | CAS号147383-72-0 Benzenepropanoi...

Ethyl 2-((S)-2-Benzyl-3-((3R,4R)-4-(3-Hydroxyphenyl)-3,4-Dimethylpiperidin-1-yl)Propanamido)Acetate Hydrochloride置于水,Sodium Hydroxide体系中,用 异丙醇 用作溶剂,化学反应 1.0H,以88.6 G的收率获得爱维莫潘
参考文献: An Improved Process For The Preparation Of [[2(S)-[[4(R)-(3-Hydroxy Phenyl)-3(R),4-Dimethyl-1-Piperidinyl]Methyl]-1-Oxo-3-Phenylpropyl] Amino]Acetic Acid Dihydrate[fr] Procédé Amélioré De Préparation De Dihydrate D'Acide [[2(S)-[[4(R)-(3-Hydroxyphényl)-3(R),4-Diméthyl-1-Pipéridinyl]Méthyl]-1-Oxo-3-Phénylpropyl]Amino]Acétique
标题: An Improved Process For The Preparation Of [[2(S)-[[4(R)-(3-Hydroxy Phenyl)-3(R),4-Dimethyl-1-Piperidinyl]Methyl]-1-Oxo-3-Phenylpropyl] Amino]Acetic Acid Dihydrate[fr] Procédé Amélioré De Préparation De Dihydrate D'Acide [[2(S)-[[4(R)-(3-Hydroxyphényl)-3(R),4-Diméthyl-1-Pipéridinyl]Méthyl]-1-Oxo-3-Phénylpropyl]Amino]Acétique
摘要:本发明涉及一种改进的制备[[2(S)-[[4(R)-(3-羟基苯基)-3(R),4-二甲基-1-哌啶基]甲基]-1-氧代-3-苯基丙基]氨基]乙酸二水合物的方法,其结构式如下:

专利信息

专利号:US-2012165520-A1
优先权日:2010-12-23
标题:Process for the synthesis of prodrugs of opioids
发明人：MCGEE PAUL; GARNETT IAN; JUAN E; MANAGE A; CARNIAUX JEAN-FRANCOIS
权利人:MCGEE PAUL; GARNETT IAN; JUAN E; MANAGE A; CARNIAUX JEAN-FRANCOIS
摘要:The present invention provides a process for the synthesis of opioid prodrugs. In particular, the present invention provides a process for the synthesis of opioid prodrugs comprising: treating an opioid, in the form of a salt or a freebase, with a carbonyl synthon to form an activated intermediate and subsequently reacting the activated intermediate with an amine, in the form of a salt or a freebase.

专利号:US-9765027-B2
优先权日:2014-08-22
标题 :Substituted 1-arylethyl-4-acylaminopiperidine derivatives as opioid/alpha-adrenoreceptor modulators and method of their preparation
发明人：VARDANYAN RUBEN S; HRUBY VICTOR J
权利人:THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIV OF ARIZAONA; UNIV ARIZONA
摘要:The invention provides compounds that bind with high affinities to the μ-, δ- and κ-opioid receptors and α 2 -adrenoreceptor. In addition to providing these compounds with novel pharmacological binding properties, the invention also describes detailed novel methods for the preparation of representative compounds and a scheme for the synthesis of related compounds that bind to the opioid receptors and/or α 2 -adrenoreceptor.

专利号:US-9580409-B2
优先权日:2011-11-07
标 题:Modulators of opioid receptors and methods of use thereof
发明人：MALCOLM SCOTT; BOWEN CARRIE; MELNICK LAURENCE; XIE LINGHONG
权利人:SUNOVION PHARMACEUTICALS INC; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as pain, neurological disorders, psychiatric disorders, and neuromuscular disorders. Compounds provided herein modulate the activity of opioid receptor (e.g., μ-opioid receptor) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

专利号:US-2023407258-A1
优先权日:2019-09-16
标 题:Treatment of disc degenerative disease and stimulation of proteoglycan synthesis by fibroblast conditioned media and formulations thereof

专利号:WO-2021055448-A1
优先权日:2019-09-16
标题:Treatment of disc degenerative disease and stimulation of proteoglycan synthesis by fibroblast conditioned media and formulations thereof

专利号:CA-3154063-A1
优先权日:2019-09-16
标 题 :Treatment of disc degenerative disease and stimulation of proteoglycan synthesis by fibroblast conditioned media and formulations thereof