CAS: 90176-80-0; 4-Fluoro-2-(Trifluoromethyl)Benzaldehyde

上下游产品

CAS号401-80-9 间氟三氟甲苯 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号207981-50-8 2,6-二氟扁桃酸 | CAS号220259-76-7 2-trifluorometh... | CAS号934557-65-0 1-(溴甲基)-4-(甲基磺酰... | CAS号63333-25-5 4-(dimethylamin...

2-溴-5-氟三氟甲苯,N,N-二甲基甲酰胺置于正丁基锂体系中,用 四氢呋喃,正己烷 作为反应溶剂,以94%的收率获得产物4-氟-2-(三氟甲基)苯甲醛
参考文献:数克级的流化学:1 S内连续合成硼酸
标题:数克级的流化学:1 S内连续合成硼酸
摘要:描述了用于以克级进行处理和执行有机锂化学反应的简单连续流设置的优点和局限性.开发的金属化平台体现了现有方法的宝贵补充,因为它结合了快速化学(在小于1 S的时间范围内进行化学合成)的优点和显着的通量(g / Min),同时降低了堵塞的风险.
DOI:10.1021/acs.Orglett.6B01681

专利信息

专利号:US-7022730-B2
优先权日:2001-10-19
标题:Bis-heteroaryl alkanes as therapeutic agents
发明人：MJALLI ADNAN M M; SHAHBAZ KATHY G J
权利人:TRANSTECH PHARMA INC
摘要:This invention provides compounds which are useful as inhibitors of protein tyrosine phosphatases (PTPases). As inhibitors of PTPases the compounds of the invention are useful for the management, treatment, control and adjunct treatment of diseases in mammals mediated by PTPase activity. Such diseases include type I diabetes, type II diabetes, immune dysfunction, AIDS, autoimmunity, glucose intolerance, obesity, cancer, psoriasis, allergic diseases, infectious diseases, inflammatory diseases, diseases involving the modulated synthesis of growth hormone or the modulated synthesis of growth factors or cytokines which affect the production of growth hormone, or Alzheimer's disease.

专利号:WO-0053313-A2
优先权日:1999-03-09
标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries

专利号:US-6689806-B1
优先权日:1999-03-24
标 题 :Indolinone compounds as kinase inhibitors
发明人：TANG PENG CHO; SUN LI; MCMAHON GERALD; MILLER TODD ANTHONY; SHIRAZIAN SHAHRZAD; WEI CHUNG CHEN; HARRIS JR G DAVIS; LI XIAOYUAN; LIANG CONGXIN
权利人:SUGEN INC
摘要:The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds of the invention. The invention also relates to methods of modulating the function of protein kinases using indolinone compounds of the invention and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.