CAS: 96-27-5; 1-Thioglycerol

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3483-12-3 6892-68-8 16096-97-2

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CAS号556-52-5 缩水甘油 | CAS号143570-34-7 4-[[(2,2-dimeth... | CAS号96-24-2 3-氯-1,2-丙二醇 | CAS号507-09-5 硫代乙酸 | CAS号7783-06-4 硫化氢 | CAS号7732-18-5 水 | CAS号18023-86-4 1,2-Propanediol... | CAS号57-55-6 丙二醇 | CAS号123017-16-3 3-tritylsulfany... | CAS号69697-53-6 4,4,5-trimethyl... | CAS号7253-53-4 (2-acetyloxy-3-... | CAS号7460-26-6 1,2-Propanediol... | CAS号85099-04-3 3-(butylthio)pr... | CAS号89104-24-5 (2,2-dimethyl-1... | CAS号5149-49-5 3-benzylsulfany...

3-氯-1,2-丙二醇置于乙醇,Potassium Hydrosulfide体系中,化学反应生成 1-硫代甘油
参考文献:Carius,Justus Liebigs Annalen Der Chemie,1862,Vol. 124,P. 236
标题:Carius,Justus Liebigs Annalen Der Chemie,1862,Vol. 124,P. 236

专利信息

专利号:US-12383499-B2
优先权日:2018-01-01
标题:Scale up synthesis of silicasome nanocarriers
发明人：NEL ANDRE E; MENG HUAN; LIU XIANGSHENG
权利人:UNIV CALIFORNIA
摘要:In order to facilitate the approval and commercialization of silicasome drug delivery systems (e.g. irinotecan silicasomes) it is necessary to scale up synthesis of the drug-loaded silicasomes. In this regard, it was discovered that the synthesis protocols used for laboratory synthesis of drug-loaded silicasomes (e.g., 500 mg/batch) do not scale to large scale silicasome production, because the resulting products were too heterogeneous for use as pharmaceuticals. Accordingly, new methods are provided herein that effectively afford the large-scale production of mesoporous silica nanoparticles (MSNPs) and lipid bilayer coated MSNPs (silicasomes).

专利号:US-5110961-A
优先权日:1989-12-21
标 题:Catalytic process for the synthesis of an alcohol, new metal complexes and process for the synthesis of these complexes
发明人：LECOLIER SERGE; MORTREUX ANDRE; PETIT FRANCIS; SAMAIN HENRI
权利人:POUDRES & EXPLOSIFS STE NALE
摘要:The invention relates to a catalytic process for the synthesis of an alcohol by reaction of an epoxide with a nucleophilic compound containing a labile hydrogen, such as an alcohol, a phenol, a primary amine or a carboxylic acid. n The catalyst is a metal complex of general formula (I) n [M[Co(CO) 4 ] 2 ] x in which x is equal to 1 or 2 and M denotes tin, lead and cadmium. n The reaction preferably takes place in the presence of carbon monoxide. n This process makes it possible to increase the yield and the selectivity of the reaction and the stereoselectivity for alcohol in the case of which the hydroxyl formed is attached to the least hindered carbon atom of the epoxide. n The invention also relates to the new complexes of formula (I) in which x equals 2. n It also relates to a process for the electrosynthesis of these new compounds by electroreduction of Co 2 (CO) 8 in an organic solvent medium in a cell in which the anode consists of the metal M, followed by isolation of the complex, the temperature of the reaction mixture and that at which the complex is isolated being lower than 25° C.

专利号:US-7202256-B2
优先权日:2004-04-14
标题:Proline CCI-779, production of and uses therefor, and two-step enzymatic synthesis of proline CCI-779 and CCI-779
发明人：GU JIANXIN; RUPPEN MARK E; RAVEENDRANATH PANOLIL; CHEW WARREN; SHAW CHIA-CHENG
权利人:WYETH CORP
摘要:Methods for the synthesis of CCI-779 and proline-CCI-779 are described, including a method involving lipase-catalyzed acetylation of 42-hydroxy of rapamycin with a vinyl ester of 2,2-bis(hydroxymethyl) propionic acid in an organic solvent followed by deprotection. Also provided are products containing proline-CCI-779 and uses thereof.

专利号:US-12221452-B2
优先权日:2017-10-04
标题:Synthesis of cantharidin
发明人：DAVIDSON MATTHEW GENE; EKLOV BRIAN MATTHEW; WUTS PETER; LOERTSCHER BRAD MELVIN; SCHOW STEVEN R
权利人:VERRICA PHARMACEUTICALS INC
摘要:The invention provides synthetic methods for the preparation of cantharidin and analogs thereof. In one aspect, the invention provides an improved Diels-Alder cycloaddition to generate a key intermediate en route to cantharidin and analogs thereof. In certain embodiments, the new Diels-Alder reaction involves reacting Compound (2) in the presence of furan, and in the absence of acid or increased pressure, in an aprotic polar solvent with slight warming, to yield Compound (1) in favorable yield and exo-endo ratio. In another aspect, the invention also provides a new Diels-Alder reaction between compounds of Formula (III) and furan to yield compounds of Formula (IV), which can then be transformed into cantharidin or analogs thereof. In yet another aspect, the invention describes a new palladium-mediated carbonylation providing another key intermediate en route to cantharidin and analogs thereof. In addition to synthetic methods, present invention also provides compounds (i.e., intermediates) useful in the synthesis of cantharidin and analogs thereof. Compounds provided herein may have biological activity, and therefore may be used in the treatment of diseases or conditions (e.g., infectious diseases and skin conditions).

专利号:US-2023402618-A1
优先权日:2020-10-27
标 题:Method for synthesis of porous monoliths of transition-metal-doped-noble-metal
发明人：SINGH KIRANPAL; BHAT YASH RAJESH; CHARAYA HEMANT; CHAUDHARI VIJAY RAMAN
权利人:LOG 9 MATERIALS SCIENT PRIVATE LIMITED
摘要:The embodiment herein provides a simple, one-pot and scalable methodology for the synthesis of porous monoliths of Transition-metal-doped-noble-metal nanoparticles for cathode catalyst in a metal-air battery, PEMFCs, AFCs, and anode catalyst in water electrolysers. Silver is used as a base material on which doping is done with the transition metals selected from Cu, Co, Mn, Fe, and Ni.

专利号:US-8183355-B2
优先权日:2006-04-28
标题 :Method for the synthesis of oligonucleotide derivatives
发明人：MORVAN FRANCOIS; MEYER ALBERT; VASSEUR JEAN-JACQUES; VIDAL SEBASTIEN; CLOAREC JEAN-PIERRE; CHEVOLOT YANN; SOUTEYRAND ELIANE
权利人:MORVAN FRANCOIS; MEYER ALBERT; VASSEUR JEAN-JACQUES; VIDAL SEBASTIEN; CLOAREC JEAN-PIERRE; CHEVOLOT YANN; SOUTEYRAND ELIANE; CENTRE NAT RECH SCIENT
摘要:Method for the synthesis of nucleotide derivatives wherein molecules of interest are grafted on the oligonucleotide with the help of a “click chemistryâ€? reaction between an azide function on the molecule of interest and an alkyne function on the oligonucleotide, or between an alkyne function on the molecule of interest and an azide function on the oligonucleotide. n Intermediate molecules, notably alkyne functionalized oligonucleotides, grafted oligonucleotides, azide functionalized oligonucleotides, oligonucleotide micro arrays containing them and the use of those grafted oligonucleotides for biological investigation and for cell targeting.