CAS: 128071-98-7; 4-Bromo-2-Fluoropyridine

上下游产品

2-氟吡啶 2-Fluoro-Pyridine 372-48-5
2-氟-3-溴吡啶 3-Bromo-2-Fluoropyridine 36178-05-9

2-氟-3-溴吡啶置于溴,Lithium Diisopropyl Amide,盐酸体系中,化学反应生成4-溴-2-氟吡啶
参考文献:Substituted Pyridines
标题:Substituted Pyridines
摘要:提供了一类包括新颖化合物的2,4-;2,3,4-;2,4,6-;2,3,4,5,6-取代吡啶.这些取代是通过本文披露的方法实现的,其中金属化的吡啶与亲电试剂发生反应.适当的亲电试剂包括co2,So2,二烷基碳酸酯,脲,甲酰胺,酰胺,羧酸酯,单烷基和二卤代烷基,氯,氟,溴和碘等卤素,金属盐,磺酮,磺酰基,醛,酮,酸酐,亚硝酸盐和亲电硼化合物,包括但不限于硼三烷氧化物和硼三卤化物.该发明更具体地披露了一种合成2,6-二氟吡啶-4-基硼酸的方法,包括:(1)将2,4,6-三氟吡啶与单水合肼反应,生成2,6-二氟-4-肼基吡啶,(2)将2,6-二氟-4-肼基吡啶与元素溴反应,生成4-溴-2,6-二氟吡啶,(3)将4-溴-2,6-二氟吡啶与有机锂化合物和硼酸盐在约0oc以下的温度下反应,生成2,6-二氟吡啶-4-基硼酸,其中所述过程在有机溶剂中进行.

专利信息

专利号:US-12435086-B2
优先权日:2020-04-29
标题:Synthesis of heterocyclic compounds
发明人：LIN JACK; WALTERS JASON
权利人:PLEXXIKON INC
摘要:Provided herein are intermediates and processes useful for facile synthesis of compounds of Formula 2:wherein R1 is C(O)R2; R2 is alkyl optionally substituted with 1-5 halogens; G is phenyl or a 5-6 membered heteroaryl optionally substituted with 1-2 R3; and each R3 is independently C1-C6 alkyl, CN, C1-C6 alkyl-CN, 3-6 membered cycloalkyl, or 4-6 membered heterocycloalkyl.

专利号:US-10226449-B2
优先权日:2013-12-20
标 题:Heterocyclic modulators of lipid synthesis and combinations thereof
发明人：HEUER TIMOTHY SEAN; OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; DUKE GREGORY; OHOL-GUPTA YAMINI; O'FARRELL MARIE
权利人:3 V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by dysregulation of a fatty acid synthase pathway by the administration of such compounds and combinations of such compounds and other therapeutic agents.

专利号:US-9428502-B2
优先权日:2012-07-03
标题:Heterocyclic modulators of lipid synthesis
发明人：OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; WAGMAN ALLAN S
权利人:3-V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds.

专利号:US-2024217965-A1
优先权日:2020-04-29
标 题 :Synthesis of heterocyclic compounds

专利号:WO-2023086799-A1
优先权日:2021-11-09
标 题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK; KAPLAN ALAN P
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:EP-3686190-A1
优先权日:2013-07-11
标 题 :Synthesis of therapeutically active compounds