CAS: 2051-18-5; 1-(Chloromethyl)-4-Isopropylbenzene

该化合物是一种多用途有机化合物,主要用作合成药品,农用化学品和特殊化学品的中间体,其活性苯基氯化物可以高效地发挥作用,使其在核生殖替代和组合反应中具有价值.异丙基化合物组会增强消毒和电子特性,影响下游应用中的反应性和选择性.该化合物的特点是在受控条件下具有稳定性,并且与一系列溶剂和试剂相容.它通常用于生产精细化学品和活性药物成分(APIs),因为高纯度和连续性能至关重要.需要妥善处理,因为其含色性和湿度性质.

结构式图片

相似化合物

19692-45-6 73789-86-3 19692-45-6

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号536-60-7 4-异丙基苯甲醇 | CAS号98-82-8 异丙基苯 | CAS号107-30-2 氯甲基甲醚 | CAS号50-00-0 甲醛 | CAS号99-87-6 4-异丙基甲苯 | CAS号7647-01-0 盐酸 | CAS号64-19-7 冰醋酸 | CAS号7782-50-5 氯气 | CAS号7646-78-8 四氯化锡 | CAS号5435-44-9 N-(1-ethoxycarb... | CAS号4476-28-2 4-异丙基苯乙酸 | CAS号4395-87-3 4-异丙基苯乙腈 | CAS号4395-73-7 4-异丙基苯甲胺 | CAS号38628-51-2 4-(2-羧乙基)苯甲酸 | CAS号22975-62-8 Benzene, 1-(1-m... | CAS号536-60-7 4-异丙基苯甲醇 | CAS号73789-86-3 对异丙基溴苄 | CAS号58420-21-6 3-(4-异丙基苯基)丙酸 | CAS号536-66-3 4-异丙基苯甲酸 | CAS号122-03-2 枯名醛

合成工艺路线路线简述

  • 合成目标产物 4-Isopropylbenzyl Chloride 主要起始原料 Cuminaldehyde
  • (文献来源)合成步骤主要原料 Cuminaldehyde
4-异丙基甲苯置于磺酰氯体系中,化学反应生成4-异丙基苄氯
参考文献:Van Zanten,B.; Nauta,W.,Recueil Des Travaux Chimiques Des Pays-Bas,1960,Vol. 79,P. 1211-1222
标题:Van Zanten,B.; Nauta,W.,Recueil Des Travaux Chimiques Des Pays-Bas,1960,Vol. 79,P. 1211-1222

海关参考信息

专利信息


专利号:US-4536599-A
优先权日:1978-08-22
标题:Synthesis of amine derivatives
发明人:MASUKO FUJIO; KATSURA TADASHI
权利人:SUMITOMO CHEMICAL CO
摘要:An amine of the formula, ##STR1## wherein R 1 , R 2 , R 3 , R 4 and R 5 are each hydrogen, alkyl or the like and n is 1, 2 or 3, including α-phenyl-β-(p-tolyl)-ethylamine, which is useful as an optically resolving agent, an intermediate of medicines and the like, is effectively produced by a novel process comprising hydrolysis of the corresponding nitrile of the formula, ##STR2## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above, followed by alkali-decomposition of the resulting amide of the formula, ##STR3## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above. An amide including the above one is effectively produced by hydrolysis of the corresponding nitrile in the presence of a base and hydrogen peroxide using an organic quaternary ammonium salt and/or a tertiary amine as a catalyst.

专利号:US-6271195-B1
优先权日:1992-06-30
标题:Aminimide-containing molecules and materials as molecular recognition agents
发明人:HOGAN JOSEPH C JR
权利人:ARQULE INC
摘要:The design and synthesis of novel aminimide-based molecular modules and the use of the modules in the construction of new molecules and fabricated materials is disclosed. The new molecules and fabricated materials are molecular recognition agents useful in the design and synthesis of drugs, and have applications in separations and materials science.

专利号:US-7999090-B2
优先权日:2000-07-07
标 题:Fungal cell wall synthesis gene
发明人:TSUKAHARA KAPPEI; HATA KATSURA; SAGANE KOJI; NAKAMOTO KAZUTAKA; TSUCHIYA MAMIKO; WATANABE NAOAKI; OHBA FUMINORI; TSUKADA ITARU; UEDA NORIHIRO; TANAKA KEIGO; KAI JUNKO
权利人:EISAI R&D MAN CO LTD
摘要:The present invention provides isolated DNA encoding a GWT1 protein having activity to confer resistance of a fungus against a compound of formula Ia, and wherein a defect of a function of the GWT1 protein leads to a decrease in the amount of a glycosylphosphatidylinositol (GPI)-anchored protein in the cell wall of a fungus.

专利号:US-7781470-B2
优先权日:1999-09-13
标题:Aminodicarboxylic acid derivatives having pharmaceutical properties
发明人:ALONSO-ALIJA CRISTINA; HEIL MARKUS; FLUBACHER DIETMAR; NAAB PAUL; PERNERSTORFER JOSEF; STASCH JOHANNES-PETER; WUNDER FRANK; DEMBOWSKY KLAUS; PERZBORN ELIZABETH; STAHL ELKE
权利人:BAYER SCHERING PHARMA AG
摘要:The invention relates to compounds of formulae (II), (IV), and (VI) as shown below, n nwherein the several variable groups are as defined in the specification and claims. Processes for making these materials, and methods for using them in the synthesis of compounds for treatment of cardiovascular disorders and fibrotic disorders are also disclosed.

专利号:WO-9518186-A1
优先权日:1993-12-28
标 题 :Modular design and synthesis of aminimide containing molecules

专利号:US-8916705-B2
优先权日:2011-10-14
标 题:Procaspase-activating compounds and compositions
发明人:HERGENROTHER PAUL J
权利人:UNIV ILLINOIS; TRUSTEES OF THE UNIVERSITY OF ILLILNOIS BOARD OF
摘要:The invention provides compounds and compositions useful for the modulation of certain enzymes. The compounds and compositions can induce of cell death, particularly cancer cell death. The invention also provides methods for the synthesis and use of the compounds and compositions, including the use of compounds and compositions in therapy for the treatment of cancer and selective induction of apoptosis in cells.
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主要参考文献

参考标题:A General, Activator-Free Palladium-Catalyzed Synthesis Of Arylacetic And Benzoic Acids From Formic Acid
作者:Lin Wang,Helfried Neumann,Matthias Beller |发布日期:2018.6.4
摘要:Carboxylative Synthesis Of Arylacetic And Benzoic Acids Using Formic Acid (Hcooh) As The Co Surrogate Was Developed. In An Improvement Over Previous Work, Co Is Generated In Situ Without The Need For Any Additional Activators. Key To Success Was The Use Of A Specific System Consisting Of Palladium Acetate And 1,2‐bis((Tert‐butyl(2‐pyridinyl)Phosphinyl)Methyl)Benzene. The Generality Of This Method Is Demonstrated

合成参考文献


摘要:Muto, K.; Yamaguchi, J., Science of Synthesis: Dearomatizations, (2026) .
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