4-异丙基甲苯置于磺酰氯体系中,化学反应生成4-异丙基苄氯 参考文献:Van Zanten,B.; Nauta,W.,Recueil Des Travaux Chimiques Des Pays-Bas,1960,Vol. 79,P. 1211-1222 标题:Van Zanten,B.; Nauta,W.,Recueil Des Travaux Chimiques Des Pays-Bas,1960,Vol. 79,P. 1211-1222
专利号:US-4536599-A 优先权日:1978-08-22 标题:Synthesis of amine derivatives 发明人:MASUKO FUJIO; KATSURA TADASHI 权利人:SUMITOMO CHEMICAL CO 摘要:An amine of the formula, ##STR1## wherein R 1 , R 2 , R 3 , R 4 and R 5 are each hydrogen, alkyl or the like and n is 1, 2 or 3, including α-phenyl-β-(p-tolyl)-ethylamine, which is useful as an optically resolving agent, an intermediate of medicines and the like, is effectively produced by a novel process comprising hydrolysis of the corresponding nitrile of the formula, ##STR2## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above, followed by alkali-decomposition of the resulting amide of the formula, ##STR3## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above. An amide including the above one is effectively produced by hydrolysis of the corresponding nitrile in the presence of a base and hydrogen peroxide using an organic quaternary ammonium salt and/or a tertiary amine as a catalyst.
专利号:US-6271195-B1 优先权日:1992-06-30 标题:Aminimide-containing molecules and materials as molecular recognition agents 发明人:HOGAN JOSEPH C JR 权利人:ARQULE INC 摘要:The design and synthesis of novel aminimide-based molecular modules and the use of the modules in the construction of new molecules and fabricated materials is disclosed. The new molecules and fabricated materials are molecular recognition agents useful in the design and synthesis of drugs, and have applications in separations and materials science.
专利号:US-7999090-B2 优先权日:2000-07-07 标 题:Fungal cell wall synthesis gene 发明人:TSUKAHARA KAPPEI; HATA KATSURA; SAGANE KOJI; NAKAMOTO KAZUTAKA; TSUCHIYA MAMIKO; WATANABE NAOAKI; OHBA FUMINORI; TSUKADA ITARU; UEDA NORIHIRO; TANAKA KEIGO; KAI JUNKO 权利人:EISAI R&D MAN CO LTD 摘要:The present invention provides isolated DNA encoding a GWT1 protein having activity to confer resistance of a fungus against a compound of formula Ia, and wherein a defect of a function of the GWT1 protein leads to a decrease in the amount of a glycosylphosphatidylinositol (GPI)-anchored protein in the cell wall of a fungus.
专利号:US-7781470-B2 优先权日:1999-09-13 标题:Aminodicarboxylic acid derivatives having pharmaceutical properties 发明人:ALONSO-ALIJA CRISTINA; HEIL MARKUS; FLUBACHER DIETMAR; NAAB PAUL; PERNERSTORFER JOSEF; STASCH JOHANNES-PETER; WUNDER FRANK; DEMBOWSKY KLAUS; PERZBORN ELIZABETH; STAHL ELKE 权利人:BAYER SCHERING PHARMA AG 摘要:The invention relates to compounds of formulae (II), (IV), and (VI) as shown below, n nwherein the several variable groups are as defined in the specification and claims. Processes for making these materials, and methods for using them in the synthesis of compounds for treatment of cardiovascular disorders and fibrotic disorders are also disclosed.
专利号:WO-9518186-A1 优先权日:1993-12-28 标 题 :Modular design and synthesis of aminimide containing molecules
专利号:US-8916705-B2 优先权日:2011-10-14 标 题:Procaspase-activating compounds and compositions 发明人:HERGENROTHER PAUL J 权利人:UNIV ILLINOIS; TRUSTEES OF THE UNIVERSITY OF ILLILNOIS BOARD OF 摘要:The invention provides compounds and compositions useful for the modulation of certain enzymes. The compounds and compositions can induce of cell death, particularly cancer cell death. The invention also provides methods for the synthesis and use of the compounds and compositions, including the use of compounds and compositions in therapy for the treatment of cancer and selective induction of apoptosis in cells.
参考标题:A General, Activator-Free Palladium-Catalyzed Synthesis Of Arylacetic And Benzoic Acids From Formic Acid 作者:Lin Wang,Helfried Neumann,Matthias Beller |发布日期:2018.6.4 摘要:Carboxylative Synthesis Of Arylacetic And Benzoic Acids Using Formic Acid (Hcooh) As The Co Surrogate Was Developed. In An Improvement Over Previous Work, Co Is Generated In Situ Without The Need For Any Additional Activators. Key To Success Was The Use Of A Specific System Consisting Of Palladium Acetate And 1,2‐bis((Tert‐butyl(2‐pyridinyl)Phosphinyl)Methyl)Benzene. The Generality Of This Method Is Demonstrated
合成参考文献
摘要:Muto, K.; Yamaguchi, J., Science of Synthesis: Dearomatizations, (2026) .