CAS: 2309-07-1; Methyl 3-(4-Hydroxy-3-Methoxyphenyl)Acrylate

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CAS号67-56-1 甲醇 | CAS号1135-24-6 阿魏酸 | CAS号121-33-5 香草醛 | CAS号186581-53-3 重氮甲烷 | CAS号7664-93-9 硫酸 | CAS号97-54-1 异丁香酚(正+反) | CAS号292638-85-8 丙烯酸甲酯 | CAS号3943-74-6 香草酸甲酯 | CAS号121-33-5 香草醛 | CAS号56024-44-3 3-(4-羟基-3-甲氧基苯基)丙酸甲酯 | CAS号458-35-5 松柏醇 | CAS号10231-47-7 3-(4-ethoxy-3-m... | CAS号1135-24-6 阿魏酸 | CAS号5396-64-5 3-(3',4'-二甲氧基苯基)丙酸甲酯 | CAS号2305-13-7 3-(4-羟基-3-甲氧基苯)-1-丙醇 | CAS号5396-66-7 methyl 2,3-dibr... | CAS号57371-44-5 3-(4-(苄氧基)-3-甲氧...

阿魏酸置于硫酸体系中,用 甲醇 用作溶剂,以96%的收率获得阿魏酸甲酯
参考文献:糖原磷酸化酶抑制剂fr258900及其类似物的构效关系:合成,酶动力学和计算研究的组合
标题:糖原磷酸化酶抑制剂fr258900及其类似物的构效关系:合成,酶动力学和计算研究的组合
摘要:合成了一系列l-苹果酸,3-羟基戊二酸和l-谷氨酸的o-或n-肉桂酸,P-香豆酰化,阿魏酸化,苯基和取代的苯基丙酸酯化衍生物,作为天然产物糖原磷酸化酶(gp)抑制剂的类似物. Fr258900(2,3-双(4-羟基肉桂酰氧基)戊二酸).这些化合物对兔肌肉糖原磷酸化酶b几乎无活性 .一项涉及先前合成的fr258900酒石酸类似物的结构活性研究表明,化合物中必须存在两个酰基部分才能构成非常好的抑制剂.使用分子建模方法(对接和定量构效关系(qsar)计算)来了解这些gp抑制剂的结合亲和力的性质.生成的gp-抑制剂复合物3D模型显示,Gp同型二聚体单元界面的极性变构位点囊和疏水性囊对于抑制剂的酰基和芳族部分的有效结合都很重要.预测qsar模型由经验和量子力学描述符组成,并提供非常好的解释和预测能力(预测系数q 2进行交叉验证程序时= 0.7-0.9).
Doi:10.1002/cplu.201402181

专利信息

专利号:JP-6490927-B2
优先权日:2014-07-01
标题 :Synthesis of Calebin A and Its Biologically Active Analogues

专利号:EA-005682-B1
优先权日:1998-10-06
标题:TRANSFORMED MUSHROOMS, IN PARTICULAR OF THE GENUS CHRYSOSPORIUM, ABLE TO THE SYNTHESIS OF HETEROLOGICAL POLYPEPTIDES

专利号:WO-2010074764-A1
优先权日:2008-12-23
标题 :Synthesis of oligomeric neolignans and their use
发明人：SNYDER SCOTT A; KONTES FERENC
权利人:UNIV COLUMBIA; SNYDER SCOTT A; KONTES FERENC
摘要:Compounds having the structure formule (I) and their uses are described herein.

专利号:EP-2886657-A1
优先权日:2013-12-19
标题 :Enzymatic synthesis of phenolic acid esters and steryl phenolates
发明人：NYSTRÖM LAURA; SCHÄR ALINE
权利人:ETH ZUERICH
摘要:The present invention relates to a method for obtaining at least one steryl phenolate from at least one phenolic acid in an enzymatic process using a lipase, wherein in a first step a) the at least one phenolic acid and at least one alcohol R 1 -OH undergo an enzymatic esterification to at least one phenolic acid ester according to reaction scheme (III)n n, and in at least one second step b) the at least one phenolic acid ester and at least one sterol R 2 -OH undergo an enzymatic transesterification using a lipase to at least one steryl phenolate according to reaction scheme (IV)

专利号:EA-027726-B1
优先权日:2014-07-01
标题:SYNTHESIS OF CALEBINE-A AND ITS BIOLOGICALLY ACTIVE ANALOGUES

专利号:CN-114478664-A
优先权日:2022-03-03
标题 :Chemical synthesis method of trans-ferulic acid-4-glucoside