7-甲氧基吲哚-2-羧酸置于喹啉,铜体系中,用71%的收率获得产物7-甲氧基吲哚 参考文献:Effects Of Indole Fatty Alcohols On The Differentiation Of Neural Stem Cell Derived Neurospheres 标题:Effects Of Indole Fatty Alcohols On The Differentiation Of Neural Stem Cell Derived Neurospheres 摘要:In A Search For Inducers Of Neuronal Differentiation To Treat Neurodegenerative Diseases Such As Alzheimer'S Disease,A Series Of Indole Fatty Alcohols (Ifas) Were Prepared. 13C (N = 18) Was Able To Promote The Differentiation Of Neural Stem Cell Derived Neurospheres Into Neurons At A Concentration Of 10 Nm. Analysis Of The Expression Of The Notch Pathway Genes In Neurospheres Treated During The Differentiation Phase With 13C (N = 18) Revealed A Significant Decrease In The Transcription Of The Notch 4 Receptor. DOI:10.1021/jm0493616
专利号:WO-2010008727-A1 优先权日:2008-06-16 标 题:Asymmetric synthesis of allyl or allene oxindoles 发明人:KOZLOWSKI MARISA C; LINTON ELIZABETH CAROL 权利人:UNIV PENNSYLVANIA; KOZLOWSKI MARISA C; LINTON ELIZABETH CAROL 摘要:The invention concerns processes for the preparation of a compound of the formula I comprising contacting a compound of formula II with a catalyst, said catalyst comprises (i) at least one of Pd and Cu and (ii) one or more of diamine, diphosphine and aminophosphine ligands; wherein Z is -C(R 5 )(R 6 )-C(R 2 )=C(R 3 )(R 4 ) and Y is -C(R 3 )(R 4 )-C(R 2 )=C(R 5 )(R 6 ) or Z is -C(R 5 )(R 6 )-C≡C-R 3 ; Y is or -C(R 3 )=C=C(R 5 )(R 6 ); X is NH, NR 15 , O or S; a is O or an integer from 1 to 4 and R 1 -R 7 and R 15 are as defined in the specification.
专利号:US-9334275-B2 优先权日:2011-12-19 标题:Processes for preparing indoles 发明人:YOSHIKAI NAOHIKO; WEI YE 权利人:UNIV NANYANG TECH 摘要:Methods for the synthesis of an indole in provided. Methods comprise oxidizing a N-aryl imine in the presence of a palladium-based catalyst, an oxidant, and a solvent.
专利号:CN-117756807-A 优先权日:2023-11-22 标题 :A method for the photocatalytic synthesis of tetracyclic quinazolinone under metal-free conditions
专利号:CN-115819406-B 优先权日:2023-02-24 标题:Synthesis of 3-(4-pyrimidine)-1H-indole compounds
专利号:CN-115819406-A 优先权日:2023-02-24 标 题 :Synthesis of 3-(4-pyrimidine)-1H-indole compounds
[参考文献]: Eduard Dolusi, Et Al. Tryptophan 2,3-Dioxygenase (Tdo) Inhibitors. 3-(2-(Pyridyl)Ethenyl)Indoles As Potential Anticancer Immunomodulators. J Med Chem. 2011 Aug 11;54(15):5320-34. [参考文献]: Giuseppe Giannini, Et Al. Exploring Bis-(Indolyl)Methane Moiety As An Alternative And Innovative Cap Group In The Design Of Histone Deacetylase (Hdac) Inhibitors. Bioorg Med Chem Lett. 2009 May 15;19(10):2840-3. [参考文献]: J M Widholm, Et Al. Utilization Of Indole Analogs By Carrot And Tobacco Cell Tryptophan Synthase In Vivo And In Vitro. Plant Physiol. 1981 Jun;67(6):1101-4. [参考文献]: Matthias Herdemann, Et Al. Identification Of Potent Itk Inhibitors Through Focused Compound Library Design Including Structural Information. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6998-7003.
合成参考文献
摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2018) 2, 164. 摘要:Harris, P. A., Science of Synthesis Knowledge Updates, (2021) 3, 37. 摘要:Nakao, Y., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 1, 407. 参考文献:10.1007/bf00404218 摘要:Grunfeld Y, Edery H. Psychopharmacological activity of the active constituents of hashish and some related cannabinoids. Psychopharmacologia. 1969;14(3):200–10. doi: 10.1007/bf00404218.