CAS: 33142-21-1; Ethyl 2-Chloro-3-Oxopropanoate

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CAS号105-39-5 氯乙酸乙酯 | CAS号109-94-4 甲酸乙酯 | CAS号64-17-5 乙醇 | CAS号1001-26-9 3-乙氧基丙烯酸乙酯 | CAS号32955-22-9 噻唑-5-甲酸乙酯 | CAS号32955-21-8 2-氨基噻唑-5-羧酸酯 | CAS号372198-69-1 6-溴咪唑并[1,2-a]吡啶... | CAS号79836-78-5 2-甲基噻唑-5-羧酸乙酯 | CAS号1296201-68-7 7-氯咪唑并[1,2-a]吡啶... | CAS号105-39-5 氯乙酸乙酯 | CAS号113853-16-0 2-氨基噁唑-5-羧酸乙酯 | CAS号30709-71-8 2-戊基噻唑-5-羧酸 | CAS号30709-68-3 2-乙基5-噻唑羧酸

Potassium (1E)-2-Chioro-3-Ethoxy-3-Oxoprop-1-En-1-Olate置于硫酸体系中,用 乙醚,水 用作溶剂,化学反应生成(氯甲酰基)乙酸乙酯
参考文献: Substituted N-(1H-Indazol-4-yl)Imidazo[1,2-A]Pyridine-3-Carboxamide Compounds As Type Iii Receptor Tyrosine Kinase Inhibitors[fr] Composés N-(1H-Indazol-4-yl)Imidazo[1,2-A]Pyridine-3-Carboxamides Substitués En Tant Qu'Inhibiteurs De Tyrosine Kinase De Récepteurs De Type Iii
标题: Substituted N-(1H-Indazol-4-yl)Imidazo[1,2-A]Pyridine-3-Carboxamide Compounds As Type Iii Receptor Tyrosine Kinase Inhibitors[fr] Composés N-(1H-Indazol-4-yl)Imidazo[1,2-A]Pyridine-3-Carboxamides Substitués En Tant Qu'Inhibiteurs De Tyrosine Kinase De Récepteurs De Type Iii
摘要:公式i的化合物及其药学上可接受的盐,在其中r1,R2,R3,R4,R5和r6具有规范中给定的含义,是cfms的抑制剂,并且在治疗哺乳动物的纤维化,与骨相关的疾病,癌症,自身免疫性疾病,炎症性疾病,心血管疾病,疼痛和烧伤方面是有用的.

专利信息

专利号:US-11225655-B2
优先权日:2010-04-16
标题:Bi-functional complexes and methods for making and using such complexes
发明人：GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK
权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS
摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

专利号:WO-2011050245-A1
优先权日:2009-10-23
标 题:Bicyclic heteroaryls as kinase inhibitors
发明人：FENG YANGBO; CHEN YEN TING; SESSIONS HAMPTON; MISHRA JITENDRA K; CHOWDHURY SARWAT; YIN YAN; LOGRASSO PHILIP; LUO JUN-LI; BANNISTER THOMAS; SCHROETER THOMAS
权利人:FENG YANGBO; CHEN YEN TING; SESSIONS HAMPTON; MISHRA JITENDRA K; CHOWDHURY SARWAT; YIN YAN; LOGRASSO PHILIP; LUO JUN-LI; BANNISTER THOMAS; SCHROETER THOMAS
摘要:The invention is directed to heteroaryl compounds useful as inhibitors of various kinase enzymes. In various embodiments, the invention provides a heteroaryl compound having inhibitory bioactivity with respect to a Rho kinase, an AKT kinase, a p70S6K kinase, a LIM kinase, an IKK kinase, a Flt kinase, an Aurora kinase, or a Src kinase, or any combination thereof. Compounds of the invention include bicyclic heteroaryl compounds of formula (I), which can contain a bridging nitrogen atom at a ring junction. The invention further provides methods of synthesis of compounds of the invention, pharmaceutical compositions, pharmaceutical combinations, and methods of treatment of malconditions using compounds of the invention.

专利号:JP-H1087639-A
优先权日:1992-12-29
标题:Useful intermediates for the synthesis of compounds that inhibit retroviral protease

专利号:US-10227344-B2
优先权日:2016-06-24
标题 :CK2 inhibitors, compositions and methods thereof
发明人：WEBBER STEPHEN E; TAO XUELIANG; BRIN ELENA
权利人:POLARIS PHARMACEUTICALS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula (I), or a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof. n nFor Formula (I) compounds R 1 , R 2 , R 3 , Ar and Z are as defined in the specification. The inventive Formula (I) compounds are inhibitors of CK2 and find utility in any number of therapeutic applications, including but not limited to treatment of proliferative disorders such as cancer, inflammation and immunological disorders.

专利号:CN-113943263-B
优先权日:2021-11-17
标题:Synthesis method of 2- (aminomethyl) -1, 3-thiazole-5-carboxylic acid methyl ester

专利号:CN-111875557-B
优先权日:2020-08-19
标 题:A kind of thiazole derivative and its synthesis method