CAS: 461-72-3; Imidazolidine-2,4-Dione

上下游产品

CAS号1032442-16-2 methyl 2-cyanam... | CAS号57-13-6 尿素 | CAS号823-76-7 乙酰基环己烷 | CAS号503-87-7 2-硫代乙内酰脲 | CAS号56-40-6 甘氨酸 | CAS号109745-70-2 methyl 2-(hydro... | CAS号108-95-2 苯酚 | CAS号108-13-4 丙二酰胺 | CAS号6293-20-5 乙内酰胺酸13C,15N乙基酯 | CAS号109754-07-6 5-(4-甲基亚苄基)咪唑烷-... | CAS号33599-32-5 1-丁基乙内酰脲 | CAS号462-60-2 海因酸 | CAS号21730-69-8 5-(2-methoxyphe... | CAS号464-72-2 苯频哪醇 | CAS号129076-79-5 5-(hydroxydiphe... | CAS号23585-90-2 2,4-Imidazolidi... | CAS号28744-91-4 5-[(3-chlorophe... | CAS号95378-36-2 2,5-二氧代咪唑烷-4-基膦酸二乙酯 | CAS号97-59-6 尿囊素

2-硫代乙内酰脲置于四丁基高碘酸铵体系中,用 二氯甲烷,乙腈 作为反应溶剂,化学反应 2.0H,以84%的收率获得产物海因
参考文献:Facile Desulfurization Of Thioamides And Thioureas With Tetrabutylammonium Periodate Under Mild Conditions
标题:Facile Desulfurization Of Thioamides And Thioureas With Tetrabutylammonium Periodate Under Mild Conditions
摘要:Thioamides And Thioureas Were Reacted With Tetrabutylammonium Periodate At Room Temperature To Afford The Corresponding Amides And Ureas,Respectively,Under Aprotic Conditions.
DOI:10.1007/s00706-005-0289-8

专利信息

专利号:US-8822702-B2
优先权日:2002-12-20
标 题 :Synthesis of amines and intermediates for the synthesis thereof
发明人：BERENS ULRICH; DOSENBACH OLIVER; SPRENGER DANIEL
权利人:BERENS ULRICH; DOSENBACH OLIVER; SPRENGER DANIEL; BASF SE
摘要:The invention relates in a first embodiment to a method for the manufacture of esters of the formula I, n nor especially of amides of the formula II,n n nwherein the symbols have the meanings given in the specification, as well as other intermediates and compounds useful in the synthesis of tryptamines and other substances mentioned in the title. The synthesis methods and intermediates are useful in the synthesis of pharmaceuticals.

专利号:US-7230101-B1
优先权日:2002-08-28
标 题:Synthesis of methotrexate-containing heterodimeric molecules
发明人：MURTHI KRISHNA K; SMITH CHASE C
权利人:GPC BIOTECH INC
摘要:The present invention relates to novel compositions of methotrexate-containing heterodimeric probe molecules, also known as chemical inducers of dimerization (CID), useful in three-hybrid assays. The invention further relates to synthesis of said compositions and their intermediates. Another aspect of the invention is a method for using the heterodimeric probe molecules described herein in drug screens to identify potential protein targets to a given ligand, optimize protein-ligand interactions, or identify potential ligands for a given protein target. In certain embodiments, the invention contemplates the synthesis of the following methotrexate-containing heterodimeric probe:

专利号:US-6515039-B1
优先权日:1998-08-28
标 题:Method for the parallel and combinatory synthesis of compounds bound to a continuous polymeric solid phase supporting material
发明人：ULBRICHT MATHIAS; VOLKMER-ENGERT RUDOLF; GERMEROTH LOTHAR; WENSCHUH HOLGER
权利人:POLY AN GMBH
摘要:The invention relates to a method for the parallel and combinatory synthesis of compounds bound to a continuous polymeric solid phase supporting material. According to the method, a continuous polymeric solid phase supporting material is prepared, the material comprising a matrix of a supporting polymeric material and graft copolymer chains covalently bound to the supporting matrix, the graft copolymer chains having reactive groups being able to react with organic compounds, thereby forming spatially defined reaction sites. The method then comprises the sequential spotting of synthesis building blocks or reagents at the various reaction sites on the continuous solid phase supporting material to yield a substrate library of compounds bound to the solid phase supporting material, whereby each reaction site on the continuous solid phase supporting material determines the composition of the synthesized compound, which is bound directly on the supporting matrix via the reactive groups of the graft polymer chain.

专利号:US-11542269-B2
优先权日:2018-01-03
标 题:Prins reaction and compounds useful in the synthesis of halichondrin macrolides and analogs thereof
发明人：CHOI HYEONG-WOOK; FANG FRANCIS G
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods utilizing Prins reaction in the preparation of compounds that may be useful as intermediates in the synthesis of halichondrin macrolides and analogs thereof. The invention also provides compounds that may be useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.

专利号:US-5549974-A
优先权日:1994-06-23
标题:Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof
发明人：HOLMES CHRISTOPHER P
权利人:AFFYMAX TECH NV
摘要:The invention provides an efficient and versatile method for the combinatorial synthesis and screening of libraries of 4-thiazolidinones, metathiazanones, and derivatives thereof. In order to expediently synthesize a combinatorial library of derivatives based upon these core structures, a general methodology for the solid phase synthesis of these derivatives is also provided. Arrays of thiazolidinones, metathiazanones, and derivatives thereof useful as peptidomimetics and for the identification of agents having antifungal, antihistaminic, or antimicrobial activity or use in the treatment of inflammation, hypertension, renal failure, congestive heart failure, uremia and other conditions can be prepared using this method.

专利号:US-10913749-B2
优先权日:2015-05-07
标 题 :Macrocyclization reactions and intermediates and other fragments useful in the synthesis of halichondrin macrolides
发明人：FANG FRANCIS G; KIM DAE-SHIK; CHOI HYEONG-WOOK; CHASE CHARLES E
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods for the synthesis of a halichondrin macrolides through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Horner-Wadsworth-Emmons olefination), catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.