CAS: 55-98-1; Butane-1,4-Diyl Dimethanesulfonate

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CAS号110-63-4 1,4-丁二醇(BDO) | CAS号124-63-0 甲基磺酰氯 | CAS号96042-30-7 2-[2-[(E)-2-[4-... | CAS号18001-91-7 trimethyl(4-tri... | CAS号109-99-9 四氢呋喃 | CAS号41138-92-5 甲磺酰溴 | CAS号40671-33-8 1-bromo-4-metha... | CAS号2386-52-9 甲烷磺酸银 | CAS号7143-01-3 甲基磺酸酐 | CAS号4096-21-3 1-苯基吡咯烷 | CAS号628-21-7 1,4-二碘丁烷 | CAS号203571-17-9 4-iodo-1-butano... | CAS号15394-33-9 2,7-二硫代辛烷 | CAS号10220-22-1 1-(4-硝基苯基)吡咯烷 | CAS号129414-26-2 4-吡咯烷-1-基苯甲酸甲酯 | CAS号21557-09-5 4’-(1-吡咯烷基)苯乙酮 | CAS号72144-83-3 cyclohexyl-[4-[... | CAS号77354-98-4 2,2-(1,4-丁烷二基二氧... | CAS号6633-90-5 1,4-丁二硫醇二乙酸

Bistrimethyl(1,4-Butanedioxy)Silane,甲基磺酰氯置于四氯化锡体系中,化学反应生成 白消安
参考文献:Mizhiritskii,M. D.; Reikhsfel'D,V. O.,Journal Of General Chemistry Of The Ussr,1986,Vol. 56,P. 1373-1382
标题:Mizhiritskii,M. D.; Reikhsfel'D,V. O.,Journal Of General Chemistry Of The Ussr,1986,Vol. 56,P. 1373-1382

专利信息

专利号:US-4704450-A
优先权日:1983-02-21
标 题 :Synthesis of hpGRF(Somatocrinin) in liquid phase and intermediate peptides
发明人：DIAZ JOSEPH; DEMARNE HENRI; RONCUCCI ROMEO; SCHMELCK PAUL-HENRY
权利人:SANOFI SA
摘要:The invention relates to synthesis of hpGRF (Somatocrinin) in liquid phase and to intermediate peptides, comprising: coupling, one after the other and in the order of the sequence of the GRF, the fragments in which: (a) the side acid functions of the aspartic and glutamic acids and the side amine function of the lysine are protected by protector groups stable in the conditions of deprotection of the group Boc, (b) the guanidine function of the arginine is protected by protonation, and (c) the N-terminal amino acid is protected on the amine by the Boc group; selectively eliminating the group Boc from the N-terminal amine of the peptide in phase of elongation by hydrolysis with trifluoroacetic acid, said coupling being effected in an aprotic polar solvent and eliminating, at the end of sequence, all the protector groups by hydrolysis with the aid of a 0.1 to 1M solution of methanesulfonic or trifluoromethanesulfonic acid in trifluoroacetic acid.

专利号:US-2016207894-A1
优先权日:2013-10-17
标 题:Synthesis of Diacids, Dialdehydes, or Diamines from THF-Diols
发明人：STENSRUD KENNETH
权利人:ARCHER DANIELS MIDLAND CO
摘要:A simple and elegant chemical process for the synthesis of oxygenated products, such as acids and aldehydes, or other derivative products, such as amines and nitriles, of cyclic bifunctional molecules made from renewable, bio-based sources such as HMF and/or its reduction product, 2,5-bis(hydroxymethyl)-tetrahydrofuran (bHMTHF) is described. In general, the process involves: a) generating a tetrahydrofuran-2,5-diyl-bis(methylene)-bis(sulfonate) from bHMTHFs using a sulfonate; b) displacing nucleophilically at least a sulfonate leaving group from the tetrahydrofuran-2,5-diyl-bis(methylene)-bis(sulfonate) to form a THF-dinitrile; and either c) oxidizing the THF-dinitrile with an acid having a pKa of ≦0 to generate a di-acid, or d) reducing partially the THF-dinitrile to generate a di-aldehyde, or e) reducing fully the THF-dinitrile to generate a di-amine.

专利号:US-5786515-A
优先权日:1995-09-15
标题 :Synthesis of α-chloro or fluoro ketones
发明人：DOLLING ULF H; FREY LISA F; TILLYER RICHARD D; TSCHAEN DAVID M
权利人:MERCK & CO INC
摘要:A simple, high yielding synthesis of a-chloro ketones is described, involving acylation of Grignard and organolithium reagents with N-methoxy-N-methylchloroacetamide. The efficiency of the process is further enhanced by recycling N,O-dimethylhydroxylamine.

专利号:US-5688968-A
优先权日:1993-03-22
标题 :Enantioselective synthesis of 5,6-dihydro-(S)-4-(ethylamino)-(S)-6-methyl-4H-thieno 2,3-B!thiopyran-2-sulfonamide 7,7-dioxide
发明人：BLACKLOCK THOMAS J; MATHRE DAVID J; SOHAR PAUL
权利人:MERCK & CO INC
摘要:A key step in the synthesis of 5,6-dihydro-(S)-4-(ethylamino)-(S)-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide (dorzolamide) and related compounds is a Ritter reaction with an unexpected tendency to proceed with retention of chirality.

专利号:US-4581168-A
优先权日:1983-02-21
标题:Synthesis of hpGRF (Somatocrinin) in liquid phase and intermediate peptides
发明人：DIAZ JOSEPH; DEMARNE HENRI; RONCUCCI ROMEO; SCHMELCK PAUL-HENRY
权利人:SANOFI SA
摘要:The invention relates to synthesis of hpGRF (Somatocrinin) in liquid phase and to intermediate peptides, comprising:--coupling, one after the other and in the order of the sequence of the GRF, the fragments in which: (a) the side acid functions of the aspartic and glutamic acids and the side amine function of the lysine are protected by protector groups stable in the conditions of deprotection of the group Boc, (b) the guanidine function of the arginine is protected by protonation, and (c) the N-terminal amino acid is protected on the amine by the Boc group;--selectively eliminating the group Boc from the N-terminal amine of the peptide in phase of elongation by hydrolysis with trifluoroacetic acid, said coupling being effected in an aprotic polar solvent and--eliminating, at the end of sequence, all the protector groups by hydrolysis with the aid of a 0.1 to 1M solution of methanesulfonic or trifluoromethanesulfonic acid in trifluoroacetic acid.

专利号:US-10975069-B2
优先权日:2014-04-01
标 题 :Sigma-2 receptor ligand drug conjugates as antitumor compounds, methods of synthesis and uses thereof
发明人：HAWKINS WILLIAM; MACH ROBERT; SPITZER DIRK; VANGVERAVONG SUWANNA; VAN TINE BRIAN
权利人:UNIV WASHINGTON
摘要:Methods and compositions for treating cancers such as pancreatic cancer and synovial sarcoma are disclosed. Compounds comprising a sigma-2 receptor-binding moiety and a ferroptosis-inducing moiety are described, such as the methanesulfonate salt of a compound of structural Formula IV, n n, wherein n is an integer chosen from 1, 2, 3, 4, and 5, and R 2 is H or methyl. At least one described molecular species exhibits an IC 50 value below 5 μM against human pancreatic cancer cells in vitro. Administration of this species promoted shrinkage of pancreatic cancer tumors in a murine model system in vivo. It led to a 100% survival of experimental animals over a time course in which control therapies provided only 30% or 40% survival. Methods of synthesis of molecular species are also disclosed.