CAS: 553-24-2; N2,N2,7-Trimethylphenazine-2,8-Diamine Hydrochloride

专利信息

专利号:US-12018313-B2
优先权日:2016-12-28
标题:Methods, apparatuses, and systems for microorganism strain analysis of complex heterogeneous communities with tracer analytics, determination of functional relationships and interactions thereof, and synthesis of microbial ensembles
发明人：EMBREE MALLORY
权利人:NATIVE MICROBIALS INC
摘要:Methods, apparatuses, and systems for microorganism strain analysis of complex heterogeneous communities with tracer analytics, determination of functional relationships and interactions thereof, and synthesis of microbial ensembles, including dosed microbial ensembles and inoculative microbial ensembles, are disclosed.

专利号:EP-0356695-B1
优先权日:1988-07-25
标 题 :In vitro synthesis of an infectious RNA
发明人：DUECHLER MARKUS; SKERN TIMOTHY DR; BLAAS DIETER DR; BERGER BERTHOLD DIPL-ING; SOMMERGRUBER WOLFGANG DR; KUECHLER ERNST PROF DR
权利人:BOEHRINGER INGELHEIM INT
摘要:The invention relates to the in vitro synthesis of an infectious RNA of HRV2 and ''full-size'' clones of HRV2.

专利号:US-2002022022-A1
优先权日:2000-05-19
标题 :Inhibition of cell proliferation and matrix synthesis by antioxidants and NAD(P)H oxidase inhibitors
发明人：SHI YI; ZALEWSKI ANDREW
摘要:The present invention is directed to a method for the prophylactic and therapeutic treatment of diseases or disorders associated with the abnormal proliferation and extracellular matrix synthesis of smooth muscle cells (SMC) and fibroblasts due to activation of NAD(P)H and/or increased ROS generation. The method involves the administration of an NAD(P)H oxidase inhibitor(s) and/or antioxidant(s) to a mammal in an amount sufficient to treat the disease or disorder prophylactically or therapeutically. The NAD(P)H oxidase inhibitor inhibits the synthesis or translocation of NAD(P)H subunits, thereby blocking the generation of intracellular reactive oxygen species (ROS) and thus the proliferation and extracellular matrix synthesis of SMC and fibroblasts. Similarly, the administration of antioxidants blocks the generation of intracellular ROS, thereby inhibiting SMC and fibroblast proliferation and extracellular matrix synthesis. In addition to the prevention and treatment of vascular disease, such as atherosclerosis, graft disease, and restenosis, NAD(P)H oxidase inhibitors and antioxidants may be useful for the prevention and treatment of other conditions by decreasing cell proliferation and extracellular matrix synthesis associated therewith. These conditions include arthritis, keloid formation, cancer, tissue and organ fibrosis, and complications related to organ transplantation, metabolic syndrome, and radiation therapy.

专利号:US-10561681-B2
优先权日:2016-07-21
标题 :Antimetastatic 2H-selenopheno[3,2-h]chromenes, synthesis thereof, and methods of using same agents
发明人：ARSENJANS PAVELS; VASILJEVA JELENA; DOMRACHEVA ILONA; SHESTAKOVA IRINA; KALVINS IVARS
权利人:LATVIAN INST ORGANIC SYNTHESIS
摘要:The present invention relates to a novel cancer metastasis preventing and curing selenopheno[h]chromene derivatives, as well as methods of their manufacturing and use in different pharmaceutical compositions for the treatment and/or prevention of primary cancer and its metastasis by administration of such substances.

专利号:US-6620796-B1
优先权日:1999-11-08
标题:Combinatorial library synthesis and pharmaceutically active compounds produced thereby
发明人：ZHOU WENQIANG; JIN YI; ROLAND ARLENE; IYER RADHAKRISHNAN
权利人:MICROLOGIX BIOTECH INC
摘要:The invention provides new methods for synthesis of nucleotide-based compounds and new libraries of such compounds. Compounds of the invention are useful for a variety of therapeutic applications, including treatment of viral or bacterial infections and associated diseases and disorders.

专利号:US-2005069551-A1
优先权日:2002-03-08
标题 :Cytotoxic compound-protein conjugates as suppressors of tumor growth and angiogenesis
发明人：SHOJI MAMORU; SNYDER JAMES P; LIOTTA DENNIS C; SUN AIMING
权利人:UNIV EMORY
摘要:Compositions and methods are provided for delivering cytotoxic compounds, such as natural curcumoids and synthetic curcumin analogs, specifically to cancer cells and to blood vessels that nourish solid tumors. The compositions include a cytotoxic drug tethered to a protein, such as factor VIIa, which can bind with high affinity to a receptor, such as tissue factor, expressed on the surface of cancer cells and vascular endothelial cells within the tumor microenvironment. Upon binding, the drug-protein-receptor complex is endocytosed and the drug is subsequently liberated inside the target cell via proteolytic cleavage. The compositions and methods may increase the efficacy of the cytotoxic agets and decrease their side effects by delivering the agents to specific target cells, such as cancer cells, vascular endothelial cells in a tumor, and metastatic foci anywhere in the body, providing the target cells express surface bound tissue factor. Additionally, methods of synthesis of cytotoxic compound-protein conjugates are provided, for example, curcuminoid-tether-linker-factor VIIa composition, as well as pharmaceutically acceptable compositions and methods for delivering a therapeutically-effective amount of a cytotoxic compound-protein conjugate together with one or more pharmaceutically acceptable carriers (additives) and/or diluents to an animal or human patient.