CAS: 5934-29-2; L-Histidine Hydrochloride Hydrate

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109425-51-6 123333-71-1 135610-90-1

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CAS号71-00-1 L-组氨酸 | CAS号2002-22-4 2-硫代组氨酸 | CAS号5354-94-9 苯甲酰-L-组氨酸一水合物 | CAS号14997-58-1 N-Cbz-L-组氨酸 | CAS号17791-52-5 B°C-组氨酸

L-组氨酸置于盐酸,水体系中,化学反应生成 L-盐酸组氨酸一水物
参考文献:Investigations On The Growth Aspects And Characterization Of Semiorganic Nonlinear Optical Single Crystals Of L-Histidine And Its Hydrochloride Derivative
标题:Investigations On The Growth Aspects And Characterization Of Semiorganic Nonlinear Optical Single Crystals Of L-Histidine And Its Hydrochloride Derivative
摘要:Semiorganic Single Crystals Of L-Histidine And L-Histidine Hydrochloride Monohydrate Have Been Obtained In A Single Solution Prepared From The Mixture Of L-Histidine And Hydrochloric Acid In 1:2 M Ratio. Growth Aspects Of The Single Crystals Have Been Discussed Along With Characterization Studies. Crystal System And Lattice Parameters Have Been Identified By X-Ray Diffraction Analyses. It Has Been Observed That The Grown Crystals Possess Orthorhombic System But With Different Set Of Lattice Parameters. Presence Of Various Functional Groups Has Been Identified And Formation Of Two Different Crystals Has Been Confirmed By Fourier Transform Infrared Spectral Analyses And Ft-Raman Studies. Linear And Nonlinear Optical Properties Have Been Studied By Uv-Vis Spectral Analyses And Kurtz-Perry Powder Technique Respectively. The Thermal Stability Of The Grown Crystals Was Determined By Thermal Analyses. From The Characterization Studies It Is Found That Both The Crystals Are Useful For Second Harmonic Generation Applications. (C) 2013 Elsevier B.V. All Rights Reserved.
DOI:10.1016/j.Saa.2013.11.021

专利信息

专利号:US-8835477-B2
优先权日:2009-10-06
标题 :Method for the synthesis of 2-thiohistidine and the like
发明人：ERDELMEIER IRÈNE; DAUNAY SYLVAIN
权利人:ERDELMEIER IRÈNE; DAUNAY SYLVAIN; TETRAHEDRON
摘要:Methods for the synthesis of 2-thiohistidine or a derivative thereof of the formula (I), or of a physiologically acceptable salt, a tautomer, a stereoisomer or a mixture of stereoisomers in any proportions thereof, from a compound of the formula (II) or a physiologically acceptable salt, a tautomer, a stereoisomer or a mixture of stereoisomers in any proportions thereof, by cleavage reaction in the presence of a thiol at a temperature higher than or equal to 60° C. The invention also relates to compounds of the formula (II) and a method for the synthesis thereof.

专利号:US-7767826-B2
优先权日:2007-10-05
标题 :Process for the synthesis of L-(+)-ergothioneine
发明人：TRAMPOTA MIROSLAV
权利人:PHARMATECH INTERNATIONAL INC
摘要:This invention relates to a novel process for the preparation of optically pure L-(+)-ergothioneine. The process for the chemical synthesis of L-ergothioneine comprises steps which consist of reacting L-histidine alkyl ester with an acid halide, chloroformate or pyrocarbonate in the presence of a base, hydrolysis of the alkyl-(S,Z)-2,4,5-triamidopent-4-enoate to obtain a (S)-alkyl 2,5-diamido-4-oxopentanoate, acid catalyzed hydrolysis of the (S)-alkyl 2,5-diamido-4-oxopentanoate followed by reaction with a metal thiocyanate to obtain the thiohistidine, protection of the sulfur of thiohistidine as the tert-butyl thioether, dialkylation of the primary amine to obtain a tertiary amine, quaternization of the tertiary amine, and removal of the protecting group to obtain the desired (S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trialkylammonio)propanoate (I). This process affords a better yield and is capable of practical application at large scale.

专利号:US-6620942-B2
优先权日:1998-12-23
标题 :Synthesis of histamine dihydrochloride
发明人：YEH WEN-LUNG; ANTCZAK CASIMIR; MCGOLRICK JEFFRY DAVID; ROTH MICHAEL JOSEPH; WRONA MARK
权利人:MAXIM PHARMACEUTICALS
摘要:The invention disclosed herein relates to the preparation of pharmaceutical grades of histamine dihydrochloride using a two step non-enzymatic synthetic method. The invention disclosed herein describes the synthesis of histamine dihydrochloride by the non-enzymatic decarboxylation of histidine and the step-wise conversion of the decarboxylated product to the dihydrochloride salt form. The invention disclosed herein considers a final product of histamine dihydrochloride containing less than each of the following: 0.8% L -histidine HCl monohydrate, 0.1% individual chromatographic impurities, and 2% total impurities, to be acceptable for pharmaceutical use.

专利号:US-11718864-B2
优先权日:2015-09-23
标 题 :Cells and method of cell culture
发明人：HILLER GREGORY WALTER; MITCHELL JEFFREY JOSEPH; MULUKUTLA BHANU CHANDRA; PEGMAN PAMELA MARY
权利人:PFIZER
摘要:The invention relates to a method of cell culture where the cells are modified to reduce the level of synthesis of growth and/or productivity inhibitors by the cell. The invention also relates to a method of cell culture for improving cell growth and productivity, in particular in fed-batch culture of mammalian cells at high cell density. The invention further relates to a method of producing cells with improved cell growth and/or productivity in cell culture and to cells obtained or obtainable by such methods.

专利号:US-2023266302-A1
优先权日:2020-07-24
标 题:Synthesis and use of n-benzyl sulfonamides
发明人：LAMAR ANGUS A; SHEAFF ROBERT J
权利人:THE UNIV OF TULSA
摘要:Disclosed is a method for preparing N-benzyl sulfonamides. Also disclosed is a composition for treating cancer. The composition includes a N-benzyl sulfonamide and a metabolic inhibitor. Also disclosed is a method for determining the impact on cell ATP levels of a composition containing a N-benzyl sulfonamide with or without a metabolic inhibitor.

专利号:US-2002035268-A1
优先权日:1998-12-23
标题 :Synthesis of histamine dihydrochloride