CAS: 7226-23-5; 1,3-Dimethyltetrahydropyrimidin-2(1H)-One

相似化合物

10166-54-8 7226-23-5 1955530-48-9

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CAS号201230-82-2 carbon monoxide | CAS号111-33-1 |N|,|N|'-二甲基-1,3-丙二胺 | CAS号124-38-9 二氧化碳 | CAS号142-28-9 1,3-二氯丙烷 | CAS号74-89-5 氨基甲烷 | CAS号1852-17-1 丙烯脲 | CAS号77-78-1 硫酸二甲酯 | CAS号107-06-2 1,2-二氯乙烷 | CAS号2055-46-1 3,4,5,6-四氢-2-嘧啶硫醇 | CAS号74-88-4 碘甲烷 | CAS号10556-96-4 pyrimidine, hex... | CAS号36404-88-3 2-氯-3-吡啶甲醛 | CAS号57102-42-8 9-(4-溴苯基)咔唑 | CAS号872-50-4 N-甲基吡咯烷酮(NMP) | CAS号431887-85-3 | CAS号300355-19-5 3-环戊基-2-(4-甲基磺酰... | CAS号25015-63-8 频那醇硼烷 | CAS号187724-98-7 2-氨基-3,5-吡咯二甲酸二乙酯 | CAS号141-53-7 甲酸钠

反应生成 N,N-二甲基丙烯基脲
参考文献:脯氨酸衍生的自燃性间隔基的快速环化可提高氨基甲酸酯前药的功效.
标题:脯氨酸衍生的自燃性间隔基的快速环化可提高氨基甲酸酯前药的功效.
摘要:自焚(si)间隔基是设计用于分子传递或材料降解的复杂化学结构.我们在本文中描述了(S)-2-(氨基甲基)吡咯烷si间隔基,其能够通过涉及氨基甲酸酯裂解的快速环化机制释放不同类型的抗癌药物(具有酚或仲和叔羟基基团).与同类型的常用间隔物相比,发现通过这种间隔物获得的高效药物释放对蛋白酶敏感性前药的体外细胞毒性活性是有益的.这些发现扩大了降解设备的范围,对高效交付平台的未来发展至关重要.
DOI:10.1002/anie.201916394

专利信息

专利号:US-2024294462-A1
优先权日:2023-02-15
标题:Method for the Synthesis of Ionizable Lipids Using a Doubly Alkylated Intermediate
发明人：SAADATI FARIBA; TRAN HUY; CIUFOLINI MARCO; ATMURI N D PRASAD
权利人:NANOVATION THERAPEUTICS INC
摘要:Provided herein is a method for the preparation of ionizable, cationic amino lipids using a doubly alkylated nucleophilic intermediate to produce a ketone. The ketone, or a corresponding alcohol, is subjected to one or more synthesis steps to add an ionizable moiety thereto. The method can be advantageously employed for the synthesis of unsymmetrical analogues of the above lipids that would be considerably more difficult to make by alternative strategies. The method can also be used to prepare symmetrical ionizable, cationic amino lipids with fewer steps and/or with the use of fewer hazardous chemicals than known synthesis methods.

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:WO-2012047907-A9
优先权日:2010-10-04
标题 :Synthesis of c5-substituted tetracyclines, uses thereof, and intermediates thereto
发明人：MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN
权利人:HARVARD COLLEGE; MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN
摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for a wide variety of substituents at position 5 of the tetracycline ring system.

专利号:WO-2024105700-A1
优先权日:2022-11-18
标 题:A method for the synthesis of anthranilic amide compounds and intermediates thereof
发明人：MALVIYA NITIN; MAL SANJIB; KLAUSENER ALEXANDER G M
权利人:PI INDUSTRIES LTD
摘要:The present invention discloses a method for the synthesis of a compound of formula (V) or a salt thereof, wherein, R, R1, R2, R3, R4a and R4b are as defined in the detailed description. The method further comprises the synthesis of an anthranilic diamide compound of formula (Z).

专利号:WO-9532946-A1
优先权日:1994-05-27
标题 :Methods for the synthesis of 9-cis retinoids and their novel intermediates
发明人：BENNANI YOUSSEF L
权利人:LIGAND PHARM INC
摘要:Methods for the synthesis of 9-cis retinoids, novel intermediates and methods for the synthesis of cyclohexadienyne nitriles and 9-cis alkyl cisoid nitriles, as well as 9-cis retinoids made using such methods are provided.

专利号:WO-2025134140-A1
优先权日:2023-12-19
标题:A method for the synthesis of substituted anthranilic amide compounds, intermediates and salts thereof
发明人：MALVIYA NITIN JAIKANT; SINGH VIPENDER; SHAH JIGARKUMAR HARKISHANDAS; KALE MANOJ GANPAT; KAVITAKE SANTOSH GIRIDHAR; BORHADE AJIT SAHEBRAO; KLAUSENER ALEXANDER G M
权利人:PI INDUSTRIES LTD
摘要:The present invention discloses a method for the synthesis of compounds of formula (I) or a salt thereof, wherein, R is selected from hydrogen, halogen, cyano, C1-C12 alkyl, C1-C12 haloalkyl, C1-C12 alkoxy, C1-C12 haloalkoxy, or C3-C8 cycloalkyl; R4 is selected from hydrogen, C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl, C1-C12 haloalkyl, C2-C12 haloalkenyl, C2-C12 haloalkynyl, C1-C12 alkoxy, C1-C12 haloalkoxy, C3-C8 cycloalkyl, or C3-C8 cycloalkyl-C1-C10 alkyl; and n represents an integer selected from 0-4. The method further comprises the synthesis of an anthranilic diamide compound of formula (A).