专利号:US-11161827-B2 优先权日:2019-04-05 标 题 :Catalytic systems for stereoselective synthesis of chiral amines by enantiodivergent radical C—H amination 发明人:Zhang xiao-xiang; Lang kai 权利人:TRUSTEES BOSTON COLLEGE; THE TRUSTEES OF BOSTON COLLEGE 摘要:In one aspect, the disclosure relates to a mode of asymmetric induction in radical processes based on sequential combination of enantiodifferentiative H-atom abstraction and stereoretentive radical substitution. Also disclosed is an asymmetric system for stereoselective synthesis of strained 5-membered cyclic sulfamides via radical 1,5-C—H amination of sulfamoyl azides. The disclosed metalloradical system can control the degree and sense of asymmetric induction in the catalytic radical C—H amination in a systematic manner. The disclosed system is applicable to a broad scope of substrates with different types of C(sp 3 )—H bonds and exhibits reactivity and selectivity, providing access to both enantiomers of useful 5-membered cyclic sulfamides in a highly enantioenriched form. Also disclosed are catalysts useful in these processes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
专利号:US-10253165-B2 优先权日:2015-02-26 标 题 :Control of organic impurities in polycarbonate synthesis 发明人:BOJARSKI AARON DAVID; GARCIA AGUDO JORGE A 权利人:SABIC GLOBAL TECHNOLOGIES BV 摘要:Polymerization processes comprising melt polymerizing a carbonate and a dihydroxy compound in the presence of an amount of a beta organic catalyst so as to give rise to a polycarbonate product, wherein the amount of beta organic catalyst comprises at least one onium salt and also comprises triphenyl phosphonium oxide (TPPO), and wherein the TPPO represents less than about 0.3 weight % of the sum of the weights of the at least one onium salt and the TPPO in the amount of beta organic catalyst.
专利号:US-4352788-A 优先权日:1979-08-09 标题 :Derivatives of 2,4,6-triiodo-isophthalic acid, processes for their synthesis and X-ray contrasting materials containing these 发明人:FELDER ERNST; PITRE DAVIDE 权利人:BRACCO IND CHIMICA SPA 摘要:Compounds for use in non-ionic X-ray contrasting materials having the formula ##STR1## in which (H0) 2-3 alkyl is 1,3-dihydroxyisopropyl, 2,3-dihydroxypropyl or 1,3-dihydroxy-2-hydroxymethylisopropyl, n R is hydrogen or methyl, and n R 1 is an alkyl residue with 1 to 5 carbon atoms. n These compounds possess high water-solubility as well as excellent stability against hydrolysis. Methods for preparation and use of the compounds are also disclosed.
专利号:WO-2018191612-A1 优先权日:2017-04-14 标 题 :Synthesis of a phosphorous containing monomer and the incorporation in polycarbonate by interfacial polymerization thereof
专利号:US-8841425-B2 优先权日:2003-05-20 标 题:Cytotoxic agents comprising new maytansinoids 发明人:CHARI RAVI V J; WIDDISON WAYNE C 权利人:CHARI RAVI V J; WIDDISON WAYNE C; IMMUNOGEN INC 摘要:New thiol and disulfide-containing maytansinoids bearing a mono or di-alkyl substitution on the α-carbon atom bearing the sulfur atom are disclosed. Also disclosed are methods for the synthesis of these new maytansinoids and methods for the linkage of these new maytansinoids to cell-binding agents. The maytansinoid-cell-binding agent conjugates are useful as therapeutic agents, which are delivered specifically to target cells and are cytotoxic. These conjugates display vastly improved therapeutic efficacy in animal tumor models compared to the previously described agents.
专利号:US-2020048410-A1 优先权日:2017-04-14 标 题:Synthesis of a phosphorous containing monomer and the incorporation in polycarbonate by interfacial polymerization thereof
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