989-51-5 = 970-74-1 反应条件:1.1 Solvents: Water; 4 H,Ph 4.2 - 4.7,37.5 °C 标题:Enhancement Of Antioxidant Activity In O/w Emulsion And Cholesterol-Reducing Capacity Of Epigallocatechin By Derivatization With Representative Phytosterols 作者:Wang,Shanshan; Fan,Jiawen; Xu,Lujing; Ye,Kai; Shu,Tong; Et Al 参考文献:Journal Of Agricultural And Food Chemistry 日期:2019 卷标:67(45) 页码:12461-12471]
989-51-5 = 970-74-1 反应条件:1.1 Solvents: Water; 10 H,Ph 5.2,40 °C; 3.5 H 标题:Enzymatic Production Of Epigallocatechin By Using An Epigallocatechin Gallate Hydrolase Induced From Aspergillus Oryzae 作者:Zhong,Kun; Shao,Zhiyu; Hong,Feng 参考文献:Biotechnology Progress 日期:2008 卷标:24(3) 页码:583-587]
= 970-74-1 [标题:Reaction Conditions 标题:Cytosine Deaminase Modulators For Enhancement Of Dna Transfection 参考文献:United States]
= 970-74-1 [标题:Reaction Conditions 标题:Process For The Preparation Of Polyphenol Compound 参考文献:World Intellectual Property Organization]
552-58-9 = 970-74-1 + 491-70-3 [标题:Reaction Conditions 标题:Integrated Transcriptomic And Metabolomic Analysis Provides Insight Into The Regulation Of Leaf Senescence In Rice 作者:Xue,Jiao; Lu,Dongbai; Wang,Shiguang; Lu,Zhanhua; Liu,Wei; Et Al 参考文献:Scientific Reports 日期:2021 卷标:11(1)]
989-51-5 = 970-74-1 反应条件:1.1 Catalysts: Tannase Solvents: Water; 12 H,35 °C 标题:Mechanism Of Oolongtheanin Formation Via Three Intermediates 作者:Hirose,Sayumi; Kamatari,Yuji O.; Yanase,Emiko 参考文献:Tetrahedron Letters 日期:2020 卷标:61(11)]
= 970-74-1 [标题:Reaction Conditions 标题:Method For Preparing Oligomer-Containing Procyanidin From Lychee Extract 参考文献:China]
= 970-74-1 [标题:Reaction Conditions 标题:Novel Process For Synthesis Of Polyphenols 参考文献:United States]
= 970-74-1 [标题:Reaction Conditions 标题:Preparation Method Of Materials Having Nitric Oxide (No) Catalytic Activity 参考文献:China]
= 970-74-1 [标题:Reaction Conditions 标题:Cytosine Deaminase Modulators For Enhancement Of Dna Transfection 参考文献:World Intellectual Property Organization]
= 970-74-1 [标题:Reaction Conditions 标题:Aminoglycosylation Can Enhance The G-Quadruplex Binding Activity Of Epigallocatechin 作者:Bai,Li-Ping; Ho,Hing-Man; Ma,Dik-Lung; Yang,Hui; Fu,Wai-Chung; Et Al 参考文献:Plos One 日期:2013 卷标:8(1)]
= 970-74-1 [标题:Reaction Conditions 标题:Methods Of Separating Catechins From Green Tea Leaves 参考文献:World Intellectual Property Organization]
= 970-74-1 [标题:Reaction Conditions 标题:Inhibitory Effects Of 3-O-Acyl-(+)-Catechins On Epstein-Barr Virus Activation 作者:Uesato,Shinichi; Taniuchi,Keisuke; Kumagai,Ayako; Nagaoka,Yasuo; Seto,Ryota; Et Al 参考文献:Chemical & Pharmaceutical Bulletin 日期:2003 卷标:51(12) 页码:1448-1450]
989-51-5 = 970-74-1 + 149-91-7 反应条件:1.1 Catalysts: Hydrolase Solvents: Water; 10 H,Ph 5.2,40 °C 标题:Enzymatic Conversion Of Epigallocatechin Gallate To Epigallocatechin With An Inducible Hydrolase From Aspergillus Niger 作者:Zhong,Kun; Zhao,Sheng-Yin; Jonsson,Leif J.; Hong,Feng 参考文献:Biocatalysis And Biotransformation 日期:2008 卷标:26(4) 页码:306-312]
989-51-5 = 970-74-1 + 880148-36-7 反应条件:1.1 Solvents: Methanol,Water; 1 D,27 °C 标题:Stereoselective Oxidation At C-4 Of Flavans By The Endophytic Fungus Diaporthe Sp. Isolated From A Tea Plant 作者:Agusta,Andria; Maehara,Shoji; Ohashi,Kazuyoshi; Simanjuntak,Partomuan; Shibuya,Hirotaka 参考文献:Chemical & Pharmaceutical Bulletin 日期:2005 卷标:53(12) 页码:1565-1569
在 镍 氢气体系中,化学反应生成 (-)-表没食子儿茶素 参考文献:Dimeric Prodelphinidins From Limonium Gmelinii Roots. Iii. 标题:Dimeric Prodelphinidins From Limonium Gmelinii Roots. Iii. 摘要:通过聚酰胺吸附色谱法从limonium Gmelinii根的水醇提取物的乙酸乙酯部分中分离出两种二聚原花青素,分别鉴定为2R,3R,4R-(-)-表没食子儿茶素-(4β-> 8)-2R,3R-(-)-表没食子儿茶素-3-O-没食子酸酯和2R,3R,4R-(-)-表没食子儿茶素-(4β-> 8)-(-)-2R,3R,3,5,7,3',4',6'-六羟基黄烷.前者首次从海薰衣草中分离得到,而后者是一种新化合物. DOI:10.1007/s10600-006-0068-8
专利号:US-2004266699-A1 优先权日:2001-10-04 标 题 :Flavonoid compounds capable of modifying the dynamic and/or physical state of biological membranes and to stimulate the endogenous synthesis of stress proteins in eukaryotic cells, relative synthesis and their use 发明人:PORTA AMALIA 摘要:The invention relates to flavonoids compounds of formula (I) and (II) capable of modifying the dynamic and/or physical state of biological membranes and to stimulate the endogenous synthesis of stress proteins in eukaryotic cells. Such compounds are molecules of plant origin or synthetic. The invention also describes a method to identify, purify and chemically synthesize such flavonoid compounds and test their efficacy through their capacity to stimulate the transcription of stress genes and as a consequence, to interact with biological membranes with alteration of their relative physical state. Such compounds and corresponding pharmaceutically acceptable derivatives and/or salts have applications in the areas of pharmaceuticals, more specifically in cosmetics and dermatology, for all those afections related to an alteration of the expression of stress genes.
专利号:WO-2024220674-A1 优先权日:2023-04-18 标题:Timescale-guided microfluidic synthesis of polyphenol-iron iii network nanocapsules of hydrophobic drugs 发明人:YEO YOON; HAN BUMSOO; SHEN YINGNAN 权利人:PURDUE RESEARCH FOUNDATION 摘要:A scalable method of continuous microfluidic synthesis of tannic acid-iron III (TA-FeIII) network (TFN) nanocapsules of a hydrophobic drug; a scalable method of continuous microfluidic synthesis of epigallocatechin-3-gallate iron III (EGCG-FeIII) network, (EFN) nanocapsules; hydrophobic drug nanocapsules synthesized in accordance with the method; and a method of administering a hydrophobic drug to a patient in need thereof by administering to the patient the hydrophobic drug nanocapsules.
专利号:US-2006128930-A1 优先权日:2004-12-03 标题 :Synthesis of sterically hindered phenol based macromolecular antioxidants 发明人:DHAWAN ASHISH; CHOLLI ASHOK L 权利人:DHAWAN ASHISH; CHOLLI ASHOK L 摘要:Disclosed is a method for the synthesis of sterically hindered polymeric antioxidants based on phenol type antioxidant monomers. The method includes polymerizing and alkylating a phenol containing monomer represented by the following structural formula: n n nto produce a sterically hindered polymeric macromolecular antioxidant. X, R 10 and q are as defined herein. The disclosed method is a simple, direct and economical process for the synthesis of sterically hindered polymeric macromolecular antioxidants.
专利号:US-7678877-B2 优先权日:2004-12-03 标题 :Process for the synthesis of polyalkylphenol antioxidants 发明人:YANG SUIZHOU; CHOLLI ASHOK L 权利人:POLNOX CORP 摘要:Disclosed is a method for the synthesis of sterically hindered polymeric antioxidants based on phenol type antioxidant monomers. The method includes partially etherifying, polymerizing and thermally rearranging a phenol containing monomer represented by the following structural formula: n nto produce a sterically hindered polymeric macromolecular antioxidant. X, R 10 and q are as defined herein. The disclosed method is a simple, direct and economical process for the synthesis of sterically hindered polymeric macromolecular antioxidants.
专利号:US-9556140-B2 优先权日:2013-01-26 标 题 :Approach for synthesis of catechins 发明人:DUGAR SUNDEEP; MAHAJAN DINESH; RAI KUMAR SANTOSH; TRIPATHI VINAYAK; PATIL ISHWAR RAKESH 权利人:SPHAERA PHARMA PRIVATE LTD 摘要:A process for synthesis of enatiomerically pure or enatiomerically enriched or racemic mixture of (+ and/or −) epicatechin and its intermediates, comprising the steps of: (i) obtaining penta-protected quercetin; (ii) reducing the penta-protected quercetin obtained from step (i); (iii) optionally deprotecting the compound of step (ii); (iv) reducing the compound obtained from step (ii) or step (iii) in the presence of a chiral/achiral reducing agent to obtain a chiral intermediate; (v) deprotecting and/or hydrogenation of the chiral intermediate obtained from step (iv) to obtain (−)-epicatechin; (vi) optionally simultaneously deprotecting and by drogenation of the compound obtained from step (ii) to obtain racemic epicatechin.
专利号:US-2021315830-A1 优先权日:2018-08-31 标题 :A curcumin loaded stabilized polymeric nanoparticles with increased solubility and photo-stability and a green process for the synthesis thereof 发明人:ACHARYA AMITABHA; KUMARI AVNESH; GULIANI ANIKA; KUMAR SANJAY 权利人:COUNCIL SCIENT IND RES 摘要:The present invention explored PLGA NPs synthesis using plant extracts as surfactants by nanoprecipitation process. PLGA NPs synthesized using Camellia sinensis, Dendrocalamus hamiltonii, Ficus palmata and Rubus ellipticus leaf extracts were further explored for encapsulation, controlled and sustained release of well-known antioxidant molecule, curcumin. This plant extract based nanoprecipitation process for the synthesis of PLGA NPs can be further explored for encapsulation of many other antioxidant molecules of therapeutic importance.
1: Xicota L, Rodríguez-Morató J, Dierssen M, de la Torre R. Potential Role of (-)-epigallocatechin-3-gallate (EGCG) in the Secondary Prevention of Alzheimer Disease. Curr Drug Targets. 2015 Aug 25. [Epub ahead of print] doi: 10.7603/s40681-015-0015-8. Epub 2015 Aug 12. 8: Ning Y, Ling J, Wu CD. Synergistic effects of tea catechin epigallocatechin gallate and antimycotics against oral Candida species. Arch Oral Biol. 2015 Jul 13;60(10):1565-1570. doi: 10.1016/j.archoralbio.2015.07.001. [Epub ahead of print] 10: Wubetu GY, Shimada M, Morine Y, Ikemoto T, Ishikawa D, Iwahashi S, Yamada S, Saito Y, Arakawa Y, Imura S. Epigallocatechin gallate hinders human hepatoma and colon cancer sphere formation. J Gastroenterol Hepatol. 2015 Aug 4. doi: 10.1111/jgh.13069. [Epub ahead of print]
合成参考文献
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