CAS: 100286-90-6; (S)-4,11-Diethyl-4-Hydroxy-3,14-Dioxo-3,4,12,14-Tetrahydro-1H-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinolin-9-Yl [1,4'-Bipiperidine]-1'-Carboxylate Hydrochloride

上下游产品

CAS号4897-50-1 4-哌啶基哌啶 | CAS号86639-52-3 7-乙基-10羟基喜树碱 | CAS号97682-44-5 伊立替康 | CAS号103816-19-9 [1,4']联哌啶-1'-甲酰氯 | CAS号35364-15-9 氨基酮 | CAS号110351-94-5 (S)-4-乙基-4-羟基-7... | CAS号924648-17-9 1-(5-fluoro-2-n... | CAS号453518-19-9 1-(5-hydroxy-2-... | CAS号456-48-4 3-氟苯甲醛 | CAS号458-02-6 3-氟苯并乙醛 | CAS号86639-52-3 7-乙基-10羟基喜树碱 | CAS号136572-09-3 盐酸伊立替康

7-乙基-10-羟基喜树碱置于吡啶,乙酰胺,盐酸,三乙胺体系中,用 二氯甲烷,水 用作溶剂,化学反应 2.0H,反应生成盐酸伊立替康
参考文献:Process For The Preparation Of 7-Ethyl-10-[4-(1-Piperidino)-1-Piperidino] Carbonyloxy-Camptothecin Hydrochloride Trihydrate
标题:Process For The Preparation Of 7-Ethyl-10-[4-(1-Piperidino)-1-Piperidino] Carbonyloxy-Camptothecin Hydrochloride Trihydrate
摘要:本发明涉及一种用于制备7-乙基-10-[4-(1-哌啶基)-1-哌啶基]羰氧基喜树碱盐酸三水合物的方法,以及用于分离1-氯羰基-4-哌啶基哌啶和1-氯羰基-4-哌啶基哌啶的新结晶形式和7-乙基-10-[4-(1-哌啶基)-1-哌啶基]羰氧基喜树碱的方法.

专利信息

专利号:US-2004242897-A1
优先权日:2002-07-31
标题 :Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-2012177593-A1
优先权日:2009-07-20
标 题 :Synthesis of dendrimer conjugates
发明人：BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH
权利人:BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH; UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis of therapeutic and diagnostic dendrimers. In particular, the present invention is directed to novel dendrimer conjugates, novel methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer, inflammatory disease) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer conjugates of the present invention may further comprise at least two different components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. Furthermore, the novel synthesis methods of certain embodiments of the present invention provide significant advantages with regard to total reaction time and simplicity.

专利号:WO-2004011474-A1
优先权日:2002-07-31
标题:Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
权利人:ISIS PHARMACEUTICALS INC; GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotide and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-6653468-B1
优先权日:2002-07-31
标 题 :Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
权利人:ISIS PHARMACEUTICALS INC
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-12391691-B2
优先权日:2018-11-16
标题:Synthesis of key intermediate of KRAS G12C inhibitor compound
发明人：PARSONS ANDREW THOMAS; COCHRAN BRIAN MCNEIL; POWAZINIK IV WILLIAM; CAPORINI MARC ANTHONY
权利人:AMGEN INC
摘要:The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure n nuseful for the synthesis of compounds that target KRAS G12C mutations, such as

专利号:US-2025206736-A1
优先权日:2019-11-14
标题 :Synthesis of kras g12c inhibitor compound
发明人：CORBETT MICHAEL THOMAS; CAILLE SEBASTIEN
权利人:AMGEN INC
摘要:The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2-isopropyl-4-methylpyridin-3-amine, useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.