CAS: 117322-30-2; Fmoc-Cycloleucine

相似化合物

35264-09-6 52-52-8 17191-44-5

上下游产品

CAS号82911-69-1 9-芴甲基-N-琥珀酰亚胺碳酸酯 | CAS号52-52-8 环亮氨酸 | CAS号28920-43-6 芴甲氧羰酰氯(Fm°C-Cl) | CAS号6940-78-9 1-溴-4-氯丁烷

9-芴甲基-N-琥珀酰亚胺基碳酸酯,环亮氨酸置于碳酸氢钠,盐酸体系中,用 水,乙腈 用作溶剂,以28%的收率获得fmoc-环亮氨酸
参考文献: Peptidyl Nitrilcompounds As Peptidase Inhibitors[fr] Composés De Peptidylnitrile à Titre D'Inhibiteurs De Peptidases
标题: Peptidyl Nitrilcompounds As Peptidase Inhibitors[fr] Composés De Peptidylnitrile à Titre D'Inhibiteurs De Peptidases
摘要:该发明涉及公式(II)化合物及其在治疗中作为肽酶抑制剂的用途.

专利信息

专利号:US-2023391818-A1
优先权日:2020-11-05
标 题:Peptide synthesis method for suppressing defect caused by diketopiperazine formation
发明人：NOMURA KENICHI; KAGE MIRAI; TAMIYA MINORU; KANAZAWA JUNICHIRO
权利人:CHUGAI PHARMACEUTICAL CO LTD
摘要:Solid-phase synthesis of a peptide has a problem that a desired elongation reaction is prevented from proceeding by diketopiperazine and a 6-membered diamine skeleton compound formed when a protective group at the N-terminal is removed. The present inventors have found that when in production of a peptide by a solid-phase method, a peptide in which an amino group at the N-terminal is protected with a protective group having an Fmoc skeleton is treated in a specific solvent with a base having a pKa of 23 or more in acetonitrile as a conjugate acid, and a peptide chain is then elongated, it is possible to solve the problem described above.

专利号:US-2020149034-A1
优先权日:2017-03-17
标题:Methods and Compositions for Synthesis of Encoded Libraries