专利号:US-4568676-A 优先权日:1983-11-25 标题:Method of inhibiting aggregation using thromboxane synthetase inhibitor in combination with a cyclic AMP phosphodiesterase inhibitor 发明人:SMITH J BRYAN 权利人:UNIV JEFFERSON 摘要:A novel method of inhibiting blood platelet aggregation is disclosed which comprises the use of a CAMP inhibitor together with an inhibitor of thromboxane synthesis. While inhibitors of thromboxane synthesis are only weak inhibitors of platelet aggregation, the addition of only a small amount of a CAMP inhibitor has been found to result in a synergistic increase in the degree of platelet aggregation resulting from such combined additions. Marked increases over the otherwise expected culumative effects of these inhibitors have been demonstrated using combination of various thromboxane synthetase inhibitors and various CAMP inhibitors.
专利号:CA-2640585-A1 优先权日:2003-02-05 标题 :Synthesis of 2-butyl-3-(2'-(1-trityl-1h-tetrazol-5-yl)biphenyl-4-yl)-1,3-diazaspirol{4,4}-non-ene-4-one
专利号:US-2004146539-A1 优先权日:2003-01-24 标 题:Topical Nutraceutical Compositions with Selective Body Slimming and Tone Firming Antiaging Benefits 发明人:GUPTA SHYAM K 摘要:I have discovered cosmetic or topical pharmaceutical compositions for external body part or organ slimming, firming, cellulite reduction, fat-reduction, and obesity control benefits that are in synergistic combination with benefits for the treatment of skin aging, skin wrinkles reduction, skin exfoliating, treatment of acne, treatment of rosacea, age-spots reduction, skin surface whitening, skin surface brightening striae distensae (stretch marks) reduction, treatment of pimples, treatment of skin infections and lesions, spider veins reduction, blood microcirculation (venous insufficiency) improvement, UVA/UVB protection of skin, and skin redness reduction. These compositions thus provide multiple combinations of skin and external body part or organ enhancement benefits that can be selective and specific for external body parts and organs such as face, chin, cheeks, arms, “love handlesâ€? in abdomen area, eye lids and eye zone, neck, breasts, thighs, and hips. These compositions include a body beneficial composition selected from certain nutraceutical, cosmetic, and pharmaceutical ingredients, a composition to promote collagen and elastin synthesis in the skin, and a cosmetically or pharmaceutically acceptable delivery ystem.
专利号:US-8354116-B2 优先权日:2007-06-18 标题 :Bifunctional synthetic molecules 发明人:CARTER STEPHEN G; PATEL KANU; ZHU ZHEN; QIAO LIXIN 权利人:BIOCHEMICS INC; CARTER STEPHEN G; PATEL KANU; ZHU ZHEN; QIAO LIXIN 摘要:The synthesis and use of bifunctional molecules to improve the topical and transdermal delivery efficiency of various types of therapeutic agents or agents designed to promote the transdermal delivery of those therapeutic agents either into the skin tissue or into the systemic circulation. Three major classes of molecules are covalently joined as bifunctional substances; chemical vasodilators, passive dermal penetration enhancers and therapeutic or diagnostic drugs. Chemical vasodilators may be delivered into the skin to increasing the blood flow in a tissue that has compromised circulation or they may be used as part of a delivery vehicle to promote the delivery of the drug. Passive dermal penetration enhancers are those chemicals that promote the passive penetration of drugs and other chemicals through the stratum corneum and epidermis of the skin tissue. Drugs and diagnostic agents are the third group of chemicals that are candidates for the linkage of molecules.
专利号:CN-107224436-A 优先权日:2017-06-23 标题 :A class of twin-drug HMG-CoA reductase inhibitors and its synthesis method