CAS: 3019-71-4; 2,2,2-Trichloroacetyl Isocyanate

上下游产品

oxalyl dichloride trichloroacetamide trichlorois°Cyanuric acid trifluoroacetyl chloride(2,2,2-Trichloro-acetyl)-thi°Carbamic acid S-cyclohex-1-enyl ester 2-phenyl-1',3'-bis-trichloroacetyl-spiro[chromene-4,2'-[1,3]diazetidin]-4'-one (2,2,2-Trichloro-acetyl)-carbamic acid 2-(2,2,2-trichloro-acetylcarbamoyl)-cyclohex-1-enyl ester 3-benzyl-2-phenyl-6-trichloromethyl-2,3-dihydro-[1,3,5]oxadiazin-4-one

三氯异氰尿酸,三氯乙酰氯 反应生成 三氯乙酰异氰酸酯
参考文献:Kukhar',V.P. Et Al.,Journal Of Organic Chemistry Ussr (English Translation),1973,Vol. 9,P. 1839-1841
标题:Kukhar',V.P. Et Al.,Journal Of Organic Chemistry Ussr (English Translation),1973,Vol. 9,P. 1839-1841

专利信息

专利号:US-2004018598-A1
优先权日:2000-05-30
标题 :Bio-intermediates for use in the chemical synthesis of polyketides
发明人：SANTI DANIEL; ASHLEY GARY; MYLES DAVID C
摘要:The present invention relates to compounds made by a subset of modules from one or more polyketide synthase (“PKSâ€?) genes that are used as starting material in the chemical synthesis of novel molecules, particularly naturally occurring polyketides or derivatives thereof. The biologically derived intermediates (“bio-intermediatesâ€?) generally represent particularly difficult compounds to synthesize using traditional chemical approaches due to one or more stereocenters. In one aspect of the invention, an intermediate in the synthesis of epothilone is provided that feeds into the synthetic protocol of Danishefsky and co-workers. In another aspect of the invention, intermediates in the synthesis of discodermolide are provided that feed into the synthetic protocol of Smith and co-workers. By taking advantage of the inherent stereochemical specificity of biological processes, the syntheses of key intermediates and thus the overall syntheses of compounds like epothilone and discodermolide are greaty simplified.

专利号:US-12234200-B2
优先权日:2019-04-16
标 题:Synthetic methods of preparing esketamine
发明人：CHEN CHENG YI
权利人:JANSSEN PHARMACEUTICA NV
摘要:The present invention is directed to methods for the asymmetric synthesis of esketamine. The present invention is further directed to key intermediates in the asymmetric esketamine synthesis. In one embodiment, the invention is an asymmetric synthesis of esketamine comprising the conversion of (S)-2′-chloro-2-methoxy-3,4,5,6-5 tetrahydro-[1, 1′-biphenyl]-3-yl carbamate to (S)-2′-chloro-1-isocyanato-6-methoxy-1,2,3,4-tetrahydro-1,1′-biphenyl.

专利号:US-9908858-B2
优先权日:2012-12-27
标题 :Method for the synthesis of a hydrazine that can be used in the treatment of the papilloma virus
发明人：BLUMENFELD MARTA; COMPERE DELPHINE; CIUFOLINI MARCO A
权利人:AVIRAGEN THERAPEUTICS INC
摘要:The invention relates to a method for producing a hydrazine of general formula (I) and the pharmaceutically acceptable salts thereof from an amine of formula (II), characterised in that said method uses a urea of formula (III) as a synthesis intermediate.

专利号:US-7592448-B2
优先权日:2003-02-28
标题:Mono amine and diamine derivatives of CL-20
发明人：GOLDING PETER; MACCUISH ALISTAIR J; BELLAMY ANTHONY JOHN
权利人:SECR DEFENCE BRIT
摘要:The invention describes the synthesis of novel mono-amine and di-amine derivatives of hexa-nitro-hexaazaisohexawurtzitane (CL-20). The synthesis is affected by the novel use of fluoroacylating compounds to protect the secondary amine groups of acylated precursors to CL-20 against nitrolysis. In so doing the mono-amine and di-amine derivatives of CL-20 are rendered and which in turn may be subsequently utilized as intermediates to generate further novel derivatives with differing physical and chemical properties to the parent compound. Formula (I), wherein: —Xâ•?H, and Yâ•?H or NO 2 .

专利号:US-7700783-B2
优先权日:2003-10-09
标题 :Synthesis of discodermolide and variants thereof
发明人：SMITH III AMOS B; FREEZE BRIAN SCOTT; XIAN MING
权利人:UNIV PENNSYLVANIA
摘要:Processes for synthesizing a compound of Formula (I) are provided by reacting a compound of Formula (i) with a compound of Formula (xx).

专利号:WO-9848791-A1
优先权日:1997-04-30
标 题:Synthesis of discodermolide and analogs
发明人：MYLES DAVID C; HARRIED SCOTT S; YANG GE
权利人:UNIV CALIFORNIA; MYLES DAVID C; HARRIED SCOTT S; YANG GE
摘要:A method for making discodermolide and analogs thereof. The method utilizes three precursors which correspond to three subparts of discodermolide which are formed by disconnecting the discodermolide carbon backbone at positions C-7 to C-8 and C-15 to C-16. Coupling of the precursors is accomplished using chelation-controlled alkylation.