CAS: 498-60-2; Furan-3-Carbaldehyde

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4412-91-3 488-93-7 614-98-2

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Methyl (E)-3-(Furan-3-yl)Acrylate置于氧气,Palladium Diacetate,对甲苯磺酸体系中,用 水 作为反应溶剂,100.0 °C,810.65 Kpa 条件下,反应 24.0H,以69%的收率获得产物3-糠醛
参考文献:钯催化的分子氧对烯烃的直接氧化:制备1,2-二元醇,醛和酮的通用和实用方法
标题:钯催化的分子氧对烯烃的直接氧化:制备1,2-二元醇,醛和酮的通用和实用方法
摘要:1,2-二醇,醛和酮是化学合成中的重要中间体,烯烃是1,2-二醇,醛和酮的可能前体.在此,提出了新颖的且环境友好的方法,该方法用于钯催化的二羟基化作用以及用氧作为唯一氧化剂的烯烃的氧化裂解.裂解反应是用酸作为添加剂在水溶液中进行的,而1,2-二醇是在碱的存在下形成的.已经证明广泛的底物范围允许单取代的芳族和脂族末端烯烃,1,2-二取代的和1,1-二取代的烯烃.二氧-Pd Ii配合物的裂解反应意味着1,2-二醇可能是烯烃裂解的关键中间体.
DOI:10.1021/jo100125Q

专利信息

专利号:US-5861532-A
优先权日:1997-03-04
标 题:Solid-phase synthesis of N-alkyl amides
发明人：BROWN EDWARD G; NUSS JOHN M
权利人:CHIRON CORP
摘要:Methods for solid phase synthesis of N-alkyl amides comprise reductive amination of carbonyl compounds using a reducing agent and an amine-containing linker bound to a solid support. The methods afford high yields of linker-bound, monoalkylated amines, and subsequent coupling with acid derivatives provide derivatized N-substituted amides in excellent yields after cleavage from the solid-phase. Compositions useful in solid phase synthesis are also described.

专利号:US-10266565-B2
优先权日:2011-04-12
标 题 :Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use
发明人：BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG-EUN
权利人:BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG EUN; THE US SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES
摘要:Novel compounds are provided that bind to polo-like kinases through the polo-box domain. In certain embodiments, the novel compounds are PEGylated peptides. The PEGylated peptides in accordance with the invention demonstrate high PBD-binding affinity. In certain embodiments, the PEGylated peptides have also achieved activities in whole cell systems. The invention also provides compounds that bind polo-like kinases through the polo-box domain and possess reduced anionic charge. Further provided are methods of design and/or synthesis of the PEGylated peptides and methods of use thereof. The invention provides methods of use of the compounds and methods of synthesis of the compounds.

专利号:US-6121054-A
优先权日:1997-11-19
标 题 :Method for separation of liquid and solid phases for solid phase organic syntheses
发明人：LEBL MICHAL
权利人:TREGA BIOSCIENCES INC
摘要:A simple, efficient apparatus and method for separation of solid and liquid phases useful in methods of high-throughput combinatorial organic synthesis of large libraries or megaarrays of organic compounds is disclosed. The apparatus and method are useful, whether as part of an automated, robotic or manual system for combinatorial organic synthesis. In a preferred embodiment, an apparatus and method of removal of liquid phase from solid phase compatible with microtiter plate type array(s) of reaction vessels is disclosed.

专利号:US-7423154-B2
优先权日:2001-03-07
标 题 :Asymmetric process for the preparation of diarylethylpiperazines derivatives and novel asymmetric diarylmethylamines as intermediates
发明人：BROWN WILLIAM; PLOBECK NIKLAS
权利人:ASTRAZENECA AB
摘要:An asymmetric synthesis of diarylmethylpiperazines is described. The synthetic route enables preparation of a variety of enatiomerically pure amines with different N-alkyl groups. The invention includes an asymmetric addition of organometallic compounds to chiral sulfinimine to give adducts in predominantly one diastereomer can subsequently be transferred into pure enantiomers of by cleavage of the chiral auxilliary which is followed by synthesis of the piperazine ring by alkylation procedures.

专利号:US-9403841-B2
优先权日:2012-01-25
标题:Phragamalin limonoids for the treatment of sexual dysfunction
发明人：WIKBERG JARL; JIRGENSONS AIGARS; LIEPINSH EDVARDS
权利人:DICOTYLEDON AB
摘要:The present invention relates to novel chemical compounds, to methods for synthesis of such compounds, and to the use of these novel compounds in the synthesis of other chemical compounds that, inter alia, may be used in the treatment of sexual dysfunction, and for eliciting enhancing effects on sexual behavior. The invention also relates to remarkable biological properties of the novel compounds in their capacity of inducing aggressive behavior.

专利号:US-11512075-B2
优先权日:2017-06-14
标 题:Synthesis of 20-nor-salvinorin A
发明人：SHENVI RYAN; ROACH JEREMY; SASANO YUSUKE; BOHN LAURA; SCHMID CULLEN
权利人:SCRIPPS RESEARCH INST
摘要:The invention provides 20-nor-salvinorin A, an analog of the kappa-opioid agonist salvinorin A. The 20-nor-salvinorin A is an active kappa-opioid modulator and can be used for treatment of medical conditions wherein modulation of the kappa-opioid receptor is medically indicated, such as pain, pruritis, depression, or inflammation, or conditions implicating perception and consciousness. 20-nor-salvinorin A can be less additive when used in treatment compared to a mu-opioid receptor agonist, and 20-nor-salvinorin A is more stable in vivo than is parent compound salvinorin A. The invention further provides synthetic intermediates and procedures for preparation of 20-nor-salvinorin A.