CAS: 70441-63-3; 4-Fluoro-N-Isopropylaniline

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CAS号350-46-9 对氟硝基苯 | CAS号371-40-4 4-氟苯胺 | CAS号108-18-9 二异丙胺 | CAS号75-26-3 2-溴丙烷 | CAS号67-64-1 丙酮 | CAS号1493-23-8 para-fluorophen... | CAS号26245-56-7 N-chloropropan-... | CAS号181705-93-1 4-氟苯溴化锌 | CAS号66602-64-0 2-chloro-N-(4-f...

对氟硝基苯置于铂体系中,用 丙酮 作为反应溶剂,化学反应生成 4-氟-N-异丙基苯胺
参考文献:Hydroxycarboxylic Acid Anilides
标题:Hydroxycarboxylic Acid Anilides
摘要:本发明涉及一种制备一般式(1)的羟基羧酸酰胺的方法:##str1##其中r.Sup.1和r.Sup.2相同或不同,可为氢,卤素,氰基,具有1至12个碳原子的直链或支链烷基,烯烃基,炔烃基或烷氧基,具有7至12个碳原子的芳基烷基,具有6至12个碳原子的环烷基或具有6至12个碳原子的芳基;r.Sup.3为氢或具有1至4个碳原子的直链或支链烷基;r.Sup.4为氢或具有1至6个碳原子的直链或支链烷基,或者r.Sup.3和r.Sup.4与它们连接的碳原子一起形成一个五元或六元环烷烃环,N为1至12的整数,其中一般式(2)的苯胺:##str2##其中r.Sup.1,R.Sup.2,R.Sup.3和r.Sup.4如一般式(1)中定义的那样,与一般式(3)的羟基羧酸在惰性溶剂的存在或不存在下,在150摄氏度至250摄氏度下反应,反应条件下挥发的成分从反应混合物中蒸馏出.

专利信息

专利号:US-5808152-A
优先权日:1997-12-12
标 题:Synthesis of N-(4-fluorophenyl)-2-hydroxy-N-(1-methylethyl)acetamide using sodium formate
发明人：PRASAD VIDYANATHA A; APPLEGATE JACQUELINE M; ERDMAN DAVID T; NEWALLIS PETER E
权利人:BAYER AG
摘要:The present invention relates to a process for making N-(4-fluorophenyl)-2-hydroxy-N-(1-methylethyl)acetamide. The process includes the steps of (a) reacting 2-chloro-N-(4-fluorophenyl)-N-(1-methylethyl)acetamide with sodium formate to form a reaction mixture that contains N-(4-fluorophenyl)-2-hydroxy-N-(1-methylethyl)acetamideformate; (b) adding an aprotic, aromatic solvent to the reaction mixture; (c) hydrolyzing the N-(4-fluorophenyl)-2-hydroxy-N-(1-methylethyl)acetamideformate in the reaction mixture and (d) recovering N-(4-fluorophenyl)-2-hydroxy-N-(1-methylethyl)acetamide from the organic phase.

专利号:US-9676783-B2
优先权日:2008-10-22
标 题:Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds
发明人：HAAS JULIA; ANDREWS STEVEN W; JIANG YUTONG; ZHANG GAN
权利人:ARRAY BIOPHARMA INC
摘要:Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.

专利号:US-10272065-B2
优先权日:2013-01-14
标题 :Gem-difluorinated C-glycoside compounds as anti-cancer agents
发明人：SLILATY STEVE N
权利人:ADVANOMICS CORP; BENOIT & COTE
摘要:The present document describes a synthesis of a class of gem-difluorinated C-glycoside compounds derived from podophyllotoxin, which may be used, but not exclusively, in oncology for the treatment of cancer. More particularly, the podophyllotoxin gem-difluorinated C-glycoconjugated derivatives display improved conformational and chemical stability, and improved cytotoxicity exhibited against drug-resistant cancer cell lines.

专利号:CN-112138651-B
优先权日:2020-09-30
标题:Platinum carbon catalyst for synthesis of flufenacet intermediate and its preparation method and application

专利号:CN-112138651-A
优先权日:2020-09-30
标 题 :Platinum-carbon catalyst for the synthesis of flufenoxamine intermediate and its preparation method and application

专利号:CN-103130715-A
优先权日:2013-01-21
标 题 :A new method for the synthesis of thioacetamide compounds