2,2-二氟乙醇,三氟甲磺酸酐 反应 1.5H,以61%的收率获得产物2,2-二氟乙基三氟甲磺酸酯 参考文献:A Solvent-Free Facile Synthesis Of (E)-Bis(Phosphonium)Ethylenes From Organo-Phosphines And Tfoch2Cf2H Reagent 标题:A Solvent-Free Facile Synthesis Of (E)-Bis(Phosphonium)Ethylenes From Organo-Phosphines And Tfoch2Cf2H Reagent 摘要:(E)-Sis(Saea)乙烯基磷基合成了在无溶剂条件下使用tfoch₂cf₂h作为试剂的产物.该反应允许在非常好的到较高的产率下制备双苯乙烯基磷基合成物. 所有已使用或计划在此处的所有内容(无论是文字,Still-Image,Video,指向更快访问)均受copyrigh,请确保未经授权,不要分发该微网站的任何内容.如有违反,我将采取法律行动以保护版权人的合法权益. DOI:10.1016/j.Tetlet.2015.09.092
专利号:US-9073935-B2 优先权日:2011-11-11 标 题:Substituted benzylspiroindolin-2-one analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M1 发明人:LINDSLEY CRAIG W; CONN P JEFFREY; WOOD MICHAEL R; HOPKINS COREY R; MELANCON BRUCE J; POSLUSNEY MICHAEL S 权利人:UNIV VANDERBILT 摘要:In one aspect, the invention relates to substituted benzylspiroindolin-2-one analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M 1 (mAChR M 1 ); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
专利号:WO-2023057548-A1 优先权日:2021-10-07 标题:Ccr6 receptor modulators 发明人:AISSAOUI HAMED; ALLEMANN OLIVER; CAROFF EVA; MEYER EMMANUEL; RICHARD-BILDSTEIN SYLVIA 权利人:IDORSIA PHARMACEUTICALS LTD 摘要:The present invention relates to compounds of Formula (I), their synthesis and use as CCR6 receptor modulators for the prevention or treatment of e.g. inflammatory/autoimmune diseases/disorders and cancer.
专利号:US-RE50050-E 优先权日:2013-06-21 标 题 :Pyrimidinedione compounds 发明人:OSLOB JOHAN; ANDERSON ROBERT; AUBELE DANIELLE; EVANCHIK MARC; FOX JONATHAN CHARLES; KANE BRIAN; LU PUPING; MCDOWELL ROBERT; RODRIGUEZ HECTOR; SONG YONGHONG; SRAN ARVINDER 权利人:MYOKARDIA INC 摘要:Provided are novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds and pharmaceutically acceptable salts thereof, are described, as well as methods for treating HCM and other forms of heart disease.
专利号:US-7803832-B2 优先权日:2004-03-18 标题 :N-(1-arylpyrazol-4L)sulfonamides and their use as parasiticides 发明人:CRITCHER DOUGLAS JAMES; WALSHE NIGEL DEREK ARTHUR; LAURET CHRISTELLE 权利人:PFIZER; PFIZER PROD INC 摘要:The invention relates to a sulfonamide compound of formula (I) or a pharmaceutically, veterinarily or agriculturally acceptable salt or solvate thereof, where the groups R 1 -R 5 are described in the description, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides.