专利号:WO-2009033499-A1 优先权日:2007-09-13 标 题 :Total synthesis of enantiopure desogestrel 发明人:TIETZE LUTZ FRIEDJAHN; KRIMMELBEIN IIGA KRISTINE 权利人:UNIV GOETTINGEN GEORG AUGUST; TIETZE LUTZ FRIEDJAHN; KRIMMELBEIN IIGA KRISTINE 摘要:The present invention relates to a total synthesis of desogestrel and derivatives thereof, and to intermediate compounds of this synthesis.
专利号:US-9505733-B2 优先权日:2011-11-18 标题:Single step enantioselective process for the preparation of 3-substituted chiral phthalides 发明人:REDDY REKULA SANTOSH; NAGA CHITHANYA KIRAN INDUKURU; ARUMUGAM SUDALAI 权利人:COUNCIL SCIENT IND RES 摘要:The present invention discloses single step, highly enantioselective catalytic oxidative cyclization process for the synthesis of 3-substituted chiral phthalides. In particular, the invention discloses asymmetric synthesis of chiral phthalides via synergetic nitrile accelerated oxidative cyclization of o-cyano substituted aryl alkenes in high yield and enantiomeric excess (ee) in short reaction time. Also, disclosed herein is “one-potâ€? asymmetric synthesis of biologically important natural compounds having 3-substituted chiral phthalide structural framework in the molecule.
专利号:US-2005250765-A1 优先权日:2000-08-16 标题 :Diazepinones as antiviral agents 发明人:CHO HIDETSURA; GOGLIOTTI ROCCO D; HAMILTON HARRIET W; KRASUTSKY ALEXEI; NAKAMURA TAKESHI; TADA HIROKI; WEBER PETER C 权利人:CHO HIDETSURA; GOGLIOTTI ROCCO D; HAMILTON HARRIET W; KRASUTSKY ALEXEI; NAKAMURA TAKESHI; TADA HIROKI; WEBER PETER C 摘要:The invention is novel compounds of formula n nwhich exhibit an improved therapeutic index and improved metabolic stability which are useful in the treatment and/or prevention of herpes viral infections. Novel intermediates useful in the synthesis of the final compounds are also part of the invention.
专利号:US-11319326-B2 优先权日:2015-03-30 标 题 :Tricyclic fused derivatives of 1-(cyclo)alkyl pyrtdin-2-one useful for the treatment of cancer 发明人:VADIVELU SARAVANAN; RAJAGOPAL SRIDHARAN; CHINNAPATTU MURUGAN; GONDRALA PAVAN KUMAR; SIVANANDHAN DHANALAKSHMI; MULAKALA CHANDRIKA 权利人:JUBILANT BIOSYS LTD 摘要:The present disclosure described heterocyclic compounds of Formula I or, its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivative thereof and pharmaceutical compositions containing them as the active ingredient. The present disclosure also describes the synthesis and characterization of aforementioned compounds to exhibit high anticancer activity. The compounds of the present disclosure are useful as medicaments and their use in the manufacture of medicaments for treatment, prevention or suppression of diseases, and conditions mediated by one or more BET family of bromodomains.
专利号:EA-011357-B1 优先权日:2003-10-07 标 题 :METHOD OF SYNTHESIS OF BENZOTHIAZEPINE COMPOUNDS
专利号:CN-112300599-B 优先权日:2020-09-18 标题 :A kind of hydrophilic anthracene fluorescent dye and its synthesis method
参考标题:Synthesis Of Phthalan Derivatives Via A Formal Intramolecular 1,3-Insertion Of Rhodium(II) Azavinyl Carbenes Into O Si Bond 作者:Shengguo Duan,Qiaoyi Xiang,Changchang Deng,Yuchen Jie,Huan Luo,Ze-Feng Xu |发布日期:2021.9 摘要:The First Formal Intramolecular 1,3-Insertion Into Osi Bond Of Rhodium(II) Azavinyl Carbene Have Been Developed, And Valuable Phthalan Derivatives Could Be Synthesized Efficiently. In Addition, Various Functional Groups Could Be Introduced To The Product Conveniently In The Assistant Of Tbaf.
合成参考文献
摘要:Yoshikai, N.; Rayner, C. M.; Graham, M. A., Science of Synthesis Knowledge Updates, (2020) 2, 58. 摘要:Pilgrim, B. S.; Tucker, M. J., Science of Synthesis Knowledge Updates, (2019) 1, 196. 摘要:Sharma, U.; Kumar, R.; Gupta, S. S.; Chandra, D., Science of Synthesis Knowledge Updates, (2022) 2, 362. 摘要:Silva, V. L. M.; Pinto, D. C. G. A.; Santos, C. M. M.; Rocha, D. H. A., Science of Synthesis Knowledge Updates, (2022) 3, 206. 摘要:Sharma, U.; Kumar, R.; Gupta, S. S.; Chandra, D., Science of Synthesis Knowledge Updates, (2022) 2, 365.