CAS: 88284-48-4; 2-(Trimethylsilyl)Phenyl Trifluoromethanesulfonate

• 英文名称2-(Trimethylsilyl)Phenyl Trifluoromethanesulfonate
• 中文名称2-(三甲基甲硅烷基)苯基三氟甲磺酸酯
• IUPAC名称2-(trimethylsilyl)phenyl trifluoromethanesulfonate
• 其它别名2-(三甲基硅基)苯基三氟甲烷磺酸盐; Trifluoromethanesulfonic Acid 2-(Trimethylsilyl)Phenyl Ester
• CAS编号88284-48-4
• MFCD编号:MFCD00799598
• EINECS号:629-383-8
• 分子式:C10H13F3O3SSi
• 分子量:298.35
• 产品CID: 1892472
• 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

• 相似结构搜索
• 产品信息参考
• InChIKey: XBHPFCIWRHJDCP-UHFFFAOYSA-N
• InChI=1S/C10H13F3O3SSi/c1-18(2,3)9-7-5-4-6-8(9)16-17(14,15)10(11,12)13/h4-7H,1-3H3…
• 计算化学: 氢键受体数3.0氢键供体数0.0可旋转键数3.0

物理性质

• 沸点294.804±40.00 °C at 760 mmHg
• 闪点96°C
• 密度1.3±0.1 g/cm3
• PSA:43.37
• LogP:2.4602
• 折射率1.470
• 蒸汽压0.0±0.6 mmHg at 25°C
• 敏感性按规定使用和贮存的不会分解，避氧化物
• 外观形态无色至淡黄色透明液体
• 储存条件在惰性气体(氮气或氩气)下 2-8°C
• 产品应用该化合物用于在室内温度下,在简单的氟化物处理的温和条件下生成苯.

MSDS等安全信息

• GHS象形图
• GHS符号GHS05;
  注释: Corrosion
• 危险类别皮肤腐蚀 类别1B
  严重眼损伤 类别1
  金属腐蚀物 类别1
• 警示词Danger(危险)
• 危险描述H314 |造成严重皮肤灼伤和眼损伤.
  H318 |造成严重眼损伤.
  H290 |可能对金属造成腐蚀.
• 防范说明P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501
• 危险等级8
• UN编号3265.0
• 危险品标志C
• 包装等级Ⅱ
• 安全声明26-27-36/37/39-45
• 危险类别码34
• WGK Germany3.0

欧盟法规

上下游产品

合成工艺路线路线简述

• 合成目标产物 2-(Trimethylsilyl)Phenyl Trifluoromethanesulfonate 主要起始原料 Trifluoromethanesulfonic Anhydride And O-(Trimethylsilyl)Phenol
• 358-23-6 + 15288-53-6 = 88284-48-4
  反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; -78 °C; 40 Min,-78 °C1.2 -78 °C; 40 Min,-78 °C; -78 °C -> Rt; 20 Min,Rt1.3 Reagents: Sodium Bicarbonate Solvents: Water; Rt
  标题:Stereoretentive Ring-Opening Metathesis Polymerization To Access All-Cis Poly(P-Phenylene Vinylene)S With Living Characteristics
  作者:Hsu,Ting-Wei; Et Al
  参考文献:Chemrxiv 日期:2020 卷标:1 页码:1-7]
  
  358-23-6 = 88284-48-4
  反应条件:1.1 Solvents: Tetrahydrofuran; 90 Min,Reflux1.2 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; -100 °C; 20 Min,-100 °C -> -80 °C; -80 °C -> -100 °C1.3 -100 °C; 20 Min,-100 °C -> -80 °C1.4 Reagents: Sodium Bicarbonate Solvents: Water; Cooled
  标题:Synthesis Of Aryl Stannanes From Silyl Triflates Via Aryne Intermediates
  作者:Lakshmi,B. Vasantha; Et Al
  参考文献:Synlett 日期:2011 卷标:(3) 页码:345-348]
  
  358-23-6 = 88284-48-4
  反应条件:1.1 45 Min,80 °C1.2 Solvents: Tetrahydrofuran; Rt -> -100 °C1.3 Reagents: Butyllithium; -100 °C; 20 Min,-100 °C -> -80 °C; -80 °C -> -100 °C1.4 -100 °C; 20 Min,-100 °C -> -80 °C
  标题:An Efficient Procedure For The Synthesis Of Ortho-Trialkylsilylaryl Triflates: Easy Access To Precursors Of Functionalized Arynes
  作者:Pena,Diego; Et Al
  参考文献:Synthesis 日期:2002 卷标:(10) 页码:1454-1458]
  
  36601-47-5 + 358-23-6 = 88284-48-4
  反应条件:1.1 Reagents: Butyllithium Solvents: Diethyl Ether,Hexane; 79.2 S,Rt1.2 Solvents: Diethyl Ether; 67 Min,Rt1.3 Reagents: Sodium Carbonate Solvents: Water; Rt
  标题:One-Pot Synthesis Of Heteroatom-Bridged Cyclic Diaryliodonium Salts
  作者:Damrath,Mattis; Et Al
  参考文献:Organic Letters 日期:2022 卷标:24(13) 页码:2562-2566]
  
  358-23-6 = 88284-48-4
  反应条件:1.1 Solvents: Tetrahydrofuran; 4 H,80 °C; 80 °C -> Rt1.2 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; -78 °C; 40 Min,-78 °C1.3 -78 °C; 40 Min,-78 °C; -78 °C -> Rt; 20 Min,Rt1.4 Reagents: Sodium Bicarbonate Solvents: Water; Cooled
  标题:Stereoretentive Ring-Opening Metathesis Polymerization To Access All-Cis Poly(P-Phenylenevinylene)S With Living Characteristics
  作者:Hsu,Ting-Wei; Et Al
  参考文献:Journal Of The American Chemical Society 日期:2020 卷标:142(28) 页码:11983-11987]
  
  358-23-6 = 88284-48-4
  反应条件:1.1 Reagents: Bromine Solvents: Acetic Acid; 30 Min,0 °C1.2 Solvents: Tetrahydrofuran; 2 H,70 °C1.3 Reagents: Butyllithium Solvents: Tetrahydrofuran; -78 °C; 1 H,-78 °C1.4 -78 °C; 1 H,-78 °C1.5 Reagents: Sodium Bicarbonate Solvents: Water; Cooled
  标题:Trifluoromethyl Aryl Sulfonates (Tfms): An Applicable Trifluoromethoxylation Reagent
  作者:Lei,Meng; Et Al
  参考文献:Tetrahedron Letters 日期:2019 卷标:60(20) 页码:1389-1392]
  
  = 88284-48-4
  反应条件:1.1 Reagents: Bromine Solvents: Acetic Acid; 0 °C; 30 Min,0 °C2.1 Solvents: Tetrahydrofuran; 2 H,Reflux; Reflux -> Rt2.2 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; -78 °C; 1.5 H,-78 °C2.3 -78 °C; 2 H,-78 °C2.4 Reagents: Sodium Bicarbonate Solvents: Water; -78 °C
  标题:Copper-Mediated Cascade C-H/n-H Annulation Of Indolocarboxamides With Arynes: Construction Of Tetracyclic Indoloquinoline Alkaloids
  作者:Zhang,Ting-Yu; Et Al
  参考文献:Organic Letters 日期:2018 卷标:20(1) 页码:220-223]
  
  18036-83-4 = 88284-48-4
  反应条件:1.1 Reagents: Tetrabutylammonium Fluoride Solvents: Tetrahydrofuran; Rt; 30 Min,Rt2.1 Reagents: Pyridine Solvents: Dichloromethane; 0 °C; 2 H,0 °C
  标题:Improved Synthesis Of The Benzyne Precursor 2-(Trimethylsilyl)Phenyl Trifluoromethanesulfonate
  作者:Atkinson,Darcy J.; Et Al
  参考文献:Synthesis 日期:2010 卷标:(6) 页码:911-913]
  
  358-23-6 + 15288-53-6 = 88284-48-4
  反应条件:1.1 Reagents: Pyridine Solvents: Dichloromethane; 0 °C; 2 H,0 °C
  标题:Improved Synthesis Of The Benzyne Precursor 2-(Trimethylsilyl)Phenyl Trifluoromethanesulfonate
  作者:Atkinson,Darcy J.; Et Al
  参考文献:Synthesis 日期:2010 卷标:(6) 页码:911-913]
  
  358-23-6 = 88284-48-4
  反应条件:1.1 Solvents: Tetrahydrofuran; Rt; 3 H,Reflux; Reflux -> Rt1.2 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; -100 °C; 20 Min,-100 °C -> -78 °C; -78 °C -> -100 °C1.3 -100 °C; 20 Min,-100 °C -> -78 °C1.4 Reagents: Sodium Bicarbonate Solvents: Water; Cooled
  标题:Acetic Acid Promoted Metal-Free Aerobic Carbon-Carbon Bond Forming Reactions At α-Position Of Tertiary Amines
  作者:Ueda,Hirofumi; Et Al
  参考文献:Organic Letters 日期:2014 卷标:16(16) 页码:4194-4197]
  
  36601-47-5 + 358-23-6 = 88284-48-4
  反应条件:1.1 Reagents: Butyllithium Solvents: Diethyl Ether; 1 Min,Rt1.2 Solvents: Diethyl Ether; 7.3 S,Rt1.3 Reagents: Sodium Carbonate Solvents: Water
  标题:Continuous-Flow Synthesis Of Trimethylsilylphenyl Perfluorosulfonate Benzyne Precursors
  作者:Michel,Boris; Et Al
  参考文献:Organic Letters 日期:2014 卷标:16(10) 页码:2684-2687]
  
  18036-83-4 + 358-23-6 = 88284-48-4
  反应条件:1.1 Reagents: Butyllithium Solvents: Diethyl Ether; 4 H,0 °C -> Rt1.2 Overnight,0 °C -> Rt
  标题:Trifluoromethanesulfonic Anhydride
  作者:Martinez,Antonio Garcia; Et Al
  参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2016 卷标:1 页码:1-17]
  
  18036-83-4 + 358-23-6 = 88284-48-4
  反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; -100 °C; 20 Min,-100 °C -> -78 °C; -78 °C -> -100 °C1.2 -100 °C; 20 Min,-100 °C -> -78 °C1.3 Reagents: Sodium Bicarbonate Solvents: Water; Cooled
  标题:Access To Highly Functionalized Indanes From Arynes And α,γ-Diketo Esters
  作者:Hu,Wanyao; Et Al
  参考文献:Organic Letters 日期:2019 卷标:21(4) 页码:941-945]
  
  18036-83-4 + 358-23-6 = 88284-48-4
  反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; -100 °C; 20 Min,-100 °C -> -78 °C; -78 °C -> -100 °C1.2 -100 °C; 20 Min,-100 °C -> -78 °C1.3 Reagents: Sodium Bicarbonate Solvents: Water; Cooled
  标题:Acetic Acid Promoted Metal-Free Aerobic Carbon-Carbon Bond Forming Reactions At α-Position Of Tertiary Amines
  作者:Ueda,Hirofumi; Et Al
  参考文献:Organic Letters 日期:2014 卷标:16(16) 页码:4194-4197]
  
  75-77-4 + 37595-74-7 = 88284-48-4
  反应条件:1.1 Reagents: Triethylamine,Isopropyl Isocyanate Solvents: Dichloromethane; 2 H,23 °C1.2 Reagents: N,N,N′,N′-Tetramethylethylenediamine,(1,1-Dimethylethyl)Dimethylsilyl 1,1,1-Trifluoromethanesulfonate Solvents: Diethyl Ether,Pentane; 5 Min,0 °C; 30 Min,0 °C -> 23 °C1.3 Reagents: N,N,N′,N′-Tetramethylethylenediamine; 23 °C -> -78 °C1.4 Reagents: Butyllithium Solvents: Hexane; 70 Min,-78 °C; 1 H,-78 °C1.5 35 Min,-78 °C; 85 Min,-78 °C1.6 Reagents: Sodium Bisulfate Solvents: Water; 45 Min,-78 °C -> 23 °C1.7 Reagents: Diethylamine,1,8-Diazabicyclo[5.4.0]Undec-7-Ene Solvents: Acetonitrile; 45 Min,40 °C; 40 °C -> 23 °C1.8 Solvents: Acetonitrile; 20 Min,23 °C; 2 H,23 °C1.9 Reagents: Sodium Bicarbonate,Sodium Bisulfate Solvents: Water; 23 °C
  标题:Efficient Synthesis Of 2-(Trimethylsilyl)Phenyl Trifluoromethanesulfonate: A Versatile Precursor To O-Benzyne
  作者:Bronner,Sarah M.; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2009 卷标:74(22) 页码:8842-8843]
  
  37595-74-7 + 15288-53-6 = 88284-48-4
  反应条件:1.1 Reagents: Triethylamine Catalysts: 4-(Dimethylamino)Pyridine Solvents: Dichloromethane; 3 H,Rt
  标题:Dual Nickel-/palladium-Catalyzed Reductive Cross-Coupling Reactions Between Two Phenol Derivatives
  作者:Xiong,Baojian; Et Al
  参考文献:Organic Letters 日期:2020 卷标:22(16) 页码:6334-6338]
  
  37595-74-7 + 15288-53-6 = 88284-48-4
  反应条件:1.1 Reagents: Triethylamine Catalysts: 4-(Dimethylamino)Pyridine Solvents: Dichloromethane; 3 H,Rt
  标题:Dual Nickel/palladium-Catalyzed Reductive Cross-Coupling Reactions Between Two Phenol Derivatives
  作者:Xiong,Baojian; Et Al
  参考文献:Chemrxiv 日期:2020 卷标:1 页码:1-8]
  
  15288-53-6 = 88284-48-4 [标题:Reaction Conditions
  标题:1,2-Difunctionalization Of Aryl Triflates: A Direct And Modular Access To Diversely Functionalized Anilines
  作者:Cho,Seoyoung; Et Al
  参考文献:Organic Letters 日期:2020 卷标:22(4) 页码:1670-1674]
  
  7440-44-0 + 88284-48-4 = 88284-48-4
  反应条件:1.1 Reagents: Cesium Fluoride,18-Crown-6 Solvents: Acetonitrile,1,2-Dichlorobenzene; Overnight,70 °C
  标题:Cycloaddition Of Benzyne To Swcnt: Towards Cnt-Based Paddle Wheels
  作者:Criado,Alejandro; Et Al
  参考文献:Chemical Communications (Cambridge 日期:2010 卷标:46(37) 页码:7028-7030]
  
  = 88284-48-4 [标题:Reaction Conditions
  标题:Assembly Of Polyfunctional Arenes With Three Contiguous And Different Substituents By Pd-Catalyzed Four-Component Reactions
  作者:Shen,Yong; Et Al
  参考文献:Cell Reports Physical Science 日期:2021 卷标:2(11)]
  
  = 88284-48-4 [标题:Reaction Conditions
  标题:Aerobic Cu-Catalyzed Oxidative 1 : 2 Coupling Of Benzynes With Terminal Alkynes
  作者:Lu,Tianhao; Et Al
  参考文献:Chemical Communications (Cambridge 日期:2020 卷标:56(59) 页码:8214-8217]
  
  = 88284-48-4 [标题:Reaction Conditions
  标题:Copper-Mediated Trifluoromethylation-Allylation Of Arynes
  作者:Yang,Xinkan; Et Al
  参考文献:Organic Letters 日期:2018 卷标:20(4) 页码:1179-1182]
  
  = 88284-48-4
  反应条件:1.1 Solvents: Tetrahydrofuran; 2 H,85 °C2.1 Reagents: Butyllithium Solvents: Tetrahydrofuran; 20 Min,-80 °C2.2 -78 °C; 30 Min,Rt2.3 Reagents: Sodium Bicarbonate Solvents: Water; Rt
  标题:Regioselective Synthesis Of 2-(2-Hydroxyaryl)Pyridines From The Reactions Of Benzynes With Pyridine N-Oxides
  作者:Shaibu,Balagopal S.; Et Al
  参考文献:Organic & Biomolecular Chemistry 日期:2012 卷标:10(34) 页码:6834-6839]
  
  75-77-4 + 17881-65-1 = 88284-48-4
  反应条件:1.1 Reagents: Sodium Solvents: Toluene; 4 H,110 °C; 30 Min,110 °C; 110 °C -> Rt1.2 Reagents: Ammonium Chloride Solvents: Methanol,Water; Neutralized,Rt2.1 Reagents: Pyridine Solvents: Dichloromethane; 2 H,0 °C; 0 °C -> Rt; 2 H,Rt2.2 Solvents: Water; Rt
  标题:Alkyl Substituted [2.2]Paracyclophane-1,9-Dienes
  作者:Lidster,Benjamin J.; Et Al
  参考文献:Organic & Biomolecular Chemistry 日期:2016 卷标:14(25) 页码:6079-6087]
  
  36601-47-5 = 88284-48-4
  反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran2.1 Reagents: Pyridine Solvents: Dichloromethane
  标题:Benzynes In Natural Product Synthesis
  作者:Hunter,Ruth F.
  参考文献:1989]
  
  75-77-4 = 88284-48-4
  反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; 2 H,-78 °C1.2 5 H,-78 °C; -78 °C -> Rt1.3 Reagents: Sodium Hydroxide Solvents: Water; 1 H,Ph 10,0 °C2.1 Reagents: Pyridine Solvents: Dichloromethane; 2 H,Rt
  标题:Synthesis Of Aryne Precursor O-Trimethylsilylphenyl Triflate
  作者:Wu,Qing-Chun; Et Al
  参考文献:Hecheng Huaxue 日期:2007 卷标:15(1) 页码:111-113

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• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
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