CAS: 108560-70-9; Gallium Maltolate
该化合物是一个协调化合物,由和麦芽醇组成,这是由碳水化合物分解产生的自然产生的化合物,这种物质一般是固体的,其特征是,由于存在可造成子离心,能够形成稳定的复合物. 麦酸盐在各个领域,包括医药化学和材料科学领域,由于其在药物交付和治疗剂,特别是癌症治疗方面的潜在应用,引起了兴趣. 化合物在有机溶剂中表现出溶解性,并因其生物活动,包括对细胞过程的影响进行了研究,其独特性能来自金属特性和麦芽醇有机特性的结合,有助于其与生物系统的再活动与互动.
物理性质
MSDS等安全信息
合成工艺路线路线简述
专利信息
专利号:US-9585890-B2
优先权日:2012-09-26
标题 :Modulators of androgen synthesis
发明人：DILLY SUZANNE; STOLOFF GREGORY; TAYLOR PAUL
权利人:TANGENT REPROFILING LTD
摘要:The present specification discloses compositions comprising at least one therapeutic compound capable of modulating androgen production and methods and uses for treating a disorder associated with androgen production using such compositions and/or compounds.
专利号:US-9808462-B2
优先权日:2012-09-26
标题 :Modulators of androgen synthesis
发明人：DILLY SUZANNE; STOLOFF GREGORY; TAYLOR PAUL
权利人:TANGENT REPROFILING LTD
摘要:The present specification discloses compositions comprising at least one therapeutic compound capable of modulating androgen production and methods and uses for treating a disorder associated with androgen production using such compositions and/or compounds.
专利号:BR-PI1003745-A2
优先权日:2010-10-18
标 题 :synthesis of metal complexes with tetracyclines, products and uses
专利号:US-2014088120-A1
优先权日:2012-09-26
标题 :Modulators of Androgen Synthesis
专利号:US-9585887-B2
优先权日:2012-09-26
标题 :Modulators of androgen synthesis
专利号:AU-2018203135-A1
优先权日:2014-05-09
标题:Modulators of androgen synthesis
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主要参考文献
1: Picken C, Fragkos KC, Eddama M, Coghlan G, Clapp LH. Adverse Events of Prostacyclin Mimetics in Pulmonary Arterial Hypertension: A Systematic Review and Meta-Analysis. J Clin Med. 2019 Apr 9;8(4). pii: E481. doi: 10.3390/jcm8040481. doi: 10.1155/2018/1015239. eCollection 2018. Review.
4: Hopper RK, Rogers R, Lawrence KM, Hedrick HL. Reply. J Pediatr. 2019 Mar;206:305-306. doi: 10.1016/j.jpeds.2018.11.033. Epub 2018 Dec 14. doi: 10.1016/j.jpeds.2018.11.034. Epub 2018 Dec 14. doi: 10.1007/s00109-018-1726-6. Epub 2018 Dec 7.
7: Bacha NC, Levy M, Guerin CL, Le Bonniec B, Harroche A, Szezepanski I, Renard JM, Gaussem P, Israel-Biet D, Boulanger CM, Smadja DM. Treprostinil treatment decreases circulating platelet microvesicles and their procoagulant activity in pediatric pulmonary hypertension. Pediatr Pulmonol. 2019 Jan;54(1):66-72. doi: 10.1002/ppul.24190. Epub 2018 Nov 28. doi: 10.1016/S2213-2600(18)30369-2. Epub 2018 Nov 23. doi: 10.1016/S2213-2600(18)30367-9. Epub 2018 Nov 23. doi: 10.1080/10717544.2018.1523257.
合成参考文献
参考文献:10.1016/j.tvjl.2014.06.023
摘要:Fecteau M, Aceto HW, Bernstein LR, Sweeney RW. Comparison of the antimicrobial activities of gallium nitrate and gallium maltolate against Mycobacterium avium subsp. paratuberculosis in vitro. The Veterinary Journal. 2014 Oct;202(1):195–7. doi: 10.1016/j.tvjl.2014.06.023.
参考文献:10.1111/jvp.12022
摘要:Pollina GF, Pepe M, Dean A, Di Marco V, Marton D. Reduction in absorption of gallium maltolate in adult horses following oral administration with food: chemistry and pharmacokinetics. J Vet Pharmacol Ther. 2013 Oct;36(5):456–61. doi: 10.1111/jvp.12022.
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