CAS: 124858-35-1; 9-Fluoro-8-(4-Hydroxypiperidin-1-yl)-5-Methyl-1-Oxo-1,5,6,7-Tetrahydropyrido[3,2,1-Ij]Quinoline-2-Carboxylic Acid

上下游产品

CAS号1128-61-6 6-氟-2-甲基喹啉 | CAS号80290-18-2 5-溴-6-氟-2-甲基喹啉 | CAS号5382-16-1 4-羟基哌啶 | CAS号77483-92-2 9-fluoro-8-brom... | CAS号79085-71-5 5-溴-6-氟-1,2,3,4...

5-溴-6-氟-2-甲基喹啉置于platinum(Iv) Oxide 盐酸,氢气体系中,用 六甲基磷酰三胺,溶剂黄146 用作溶剂,化学反应 10.5H,反应生成那地沙星
参考文献:抗菌剂的研究.I.取代的6,7-二氢-1-氧代-1H,5H-苯并[i,J]喹啉嗪-2-羧酸的合成.
标题:抗菌剂的研究.I.取代的6,7-二氢-1-氧代-1H,5H-苯并[i,J]喹啉嗪-2-羧酸的合成.
摘要:合成了一系列取代的6,7-二氢-1-氧代-1H,5H-苯并[i,J]喹啉嗪-2-羧酸,并测试了其抗菌活性.其中9-氟-6,7-二氢-5-甲基-8-(4-甲基-1-哌嗪基)-1-氧代-1H,5H-苯并[i,J]喹啉嗪-2-羧酸( Opc-7241)对革兰氏阳性和阴性细菌(包括金黄色葡萄球菌和铜绿假单胞菌以及9-氟-6,7-二氢-8-(4-羟基-1-哌啶基)-5-甲基)表现出有效的抗菌活性-1-氧代-1H,5H-苯并[i,J]喹啉嗪-2-羧酸(opc-7251)具有有效的抗痤疮丙酸杆菌的活性.
Doi:10.1248/cpb.37.2103

专利信息

专利号:US-8093381-B2
优先权日:2007-05-24
标题:Method of synthesis of fluoroquinolones
发明人：BERTHON-CEDILLE LAURENCE; LEGUERN MARIE-EMMANUELLE; RENAUD GILLES; TOMBRET FRANCIS
权利人:BERTHON-CEDILLE LAURENCE; LEGUERN MARIE-EMMANUELLE; RENAUD GILLES; TOMBRET FRANCIS; BIOCODEX
摘要:The invention relates to a method of preparation of fluoroquinolones of formula (I) from compounds of formula (II): n nin which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and X are as defined in Claim 1.

专利号:US-2010203587-A1
优先权日:2009-01-13
标 题:Use of dna gyrase inhibitors for in vitro polypeptide synthesis reactions
发明人：VOLOSHIN ALEXEI M; ZAWADA JAMES F; GOLD DANIEL
权利人:SUTRO BIOPHARMA INC
摘要:The present invention provides methods and compositions useful for in vitro polypeptide synthesis reactions. The methods involve the use of DNA gyrase inhibitors to prevent bacterial contamination in lysates used for in vitro production of polypeptides. The compositions include contamination-free cell lysates for in vitro protein synthesis reactions.

专利号:US-2024207302-A1
优先权日:2021-04-01
标 题 :Antiviral compounds, methods for the manufacturing of compounds, antiviral pharmaceutical composition, use of the compounds and method for the oral treatment of coronavirus infection and related diseases thereof
发明人：CALIXTO JOãO BATISTA; RABI NALLAR JAIME ALBERTO; LOPES E SOUZA THIAGO MORENO
权利人:CALIXTO JOAO BATISTA; RABI NALLAR JAIME ALBERTO; LOPES E SOUZA THIAGO MORENO
摘要:The present invention relates to antiviral compounds selected from cytokinins, their nucleosides and nucleotide analogs, and their prodrugs as inhibitors of viral RNA synthesis, or their salts, solvates, derivatives, or even combinations of aforementioned compounds, for prophylactic treatment, curative (therapeutic) or mitigative coronavirus infection, represented by human and veterinary coronavirus, SARS-COV-2 and MHIV, and for the treatment of individuals potentially exposed to COVID-19. The present invention also comprises the methods for the manufacturing of such compounds, the antiviral pharmaceutical composition containing the compounds of the invention, as well as the use of the compounds, combinations of compounds, and method for the prophylactic, curative (therapeutic) or mitigative treatment of coronavirus infection, represented by coronavirus, in especial SARS-COV-2 and of patients with COVID-19, individual infected with SARS-COV-2 or potentially exposed to this virus. The antiviral activity of the compounds of this invention against SARS-COV-2 was greatly enhanced by inhibiting the 3′-5′-exonuclease. Synergistic results of the compounds according to the present invention were obtained from the combination with repurposed drugs.

专利号:US-7632944-B2
优先权日:2007-01-24
标题 :Quinolone carboxylic acids, derivatives thereof, and methods of making and using same
发明人：HARMS ARTHUR E
权利人:BAUSCH & LOMB
摘要:A process of preparing a quinolone carboxylic acid or its derivatives having Formula I, Ia, or IV, as shown herein, comprises using a starting quinolone that already has one or more desired substituents at one or more particular positions on the quinolone ring and preserving the orientation of such substituents throughout the synthesis. The present process comprises fewer steps than prior-art processes. The present process also can include a simple separation of a desired enantiomer of the quinolone carboxylic acid or its derivatives from the enantiomeric mixture. Pharmaceutical compositions comprising fluoroquinolones prepared by the present process can be used effectively against a variety of microbial pathogens.

专利号:US-8227597-B2
优先权日:2006-10-06
标题 :Quinolone carboxylic acids, derivatives thereof, and methods of making and using same
发明人：HARMS ARTHUR E
权利人:HARMS ARTHUR E; BAUSCH & LOMB
摘要:A process of preparing a quinolone carboxylic acid or its derivatives having Formula I, Ia, or IV, as shown herein, comprises using a starting quinolone that already has one or more desired substituents at one or more particular positions on the quinolone ring and preserving the orientation of such substituents throughout the synthesis. The present process comprises fewer steps than prior-art processes. The present process also can include a simple separation of a desired enantiomer of the quinolone carboxylic acid or its derivatives from the enantiomeric mixture. Pharmaceutical compositions comprising fluoroquinolones prepared by the present process can be used effectively against a variety of microbial pathogens.

专利号:US-2009054643-A1
优先权日:2007-05-24
标 题:Novel method of synthesis of fluoroquinolones