CAS: 148766-37-4; (R)-2-Amino-3-Mercapto-2-Methylpropanoic Acid Hydrochloride

相似化合物

151062-55-4 10318-18-0 32443-99-5

Methyl (2R,4R)-2-(Tert-Butyl)-3-Formyl-4-Methyl-1,3-Thiazolidine-4-Carboxylate置于盐酸体系中,用 水 用作溶剂,化学反应生成2-甲基-L-半胱氨酸盐酸盐
参考文献:含半胱氨酸的铑配体的半三明治复合物†
标题:含半胱氨酸的铑配体的半三明治复合物†
摘要:由l-半胱氨酸盐酸盐甲酯制备修饰的半胱氨酸配体s-苄基-α-甲基-L-半胱氨酸(hl2).商业广告的反应小号苄基大号半胱氨酸(hl1)或hl2与二聚体,[{(η 5-C 5我5)的rhcl} 2(μ-Cl)的2 ],产生了阳离子络合物,[ (η 5-C 5我5)的rhcl(hl)] Cl(上hl = Hl1(1),Hl2(2)),其中,所述配位体的半胱氨酸呈现κ 2 ñ,小号协调模式.在碱性介质中,Hl1或hl2与发生反应[{(η 5-C 5我5)的rhcl} 2(μ-Cl)的2 ],得到两种差向异构体的混合物在中性络合物的金属中心,[(η 5-C 5我5)的rhcl(κ 2 ñ,ö-大号)](hl = Hl1(3),Hl2(4)),其中氨基羧酸盐采用κ 2 ñ,ö具有可变量的阳离子化合物的沿协调模式,[(η 5-C 5我5)的rh(κ 3 ñ,ö,小号-大号)]氯(hl =
Doi:10.1039/c6Dt02411D

专利信息

专利号:US-6849650-B2
优先权日:1998-02-27
标 题:Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THORSETT EUGENE D; PORTER WARREN J; NISSEN JEFFREY S; LATIMER LEE H; AUDIA JAMES E; DROSTE JAMES
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:JP-2005538950-A
优先权日:2002-05-15
标题:Synthesis of 2-alkylcysteine, 2- (hydroxylated phenyl) -4-alkylthiazoline-4-carboxylic acids and their derivatives

专利号:JP-2007001986-A
优先权日:2002-05-15
标 题 :Synthesis of 2-alkylcysteine, 2- (hydroxylated phenyl) -4-alkylthiazoline-4-carboxylic acids and their derivatives

专利号:US-2003130188-A1
优先权日:1998-02-27
标 题:Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds

专利号:US-2018057510-A1
优先权日:2015-03-06
标题:Synthesis and Utility of New Capgroup Largazole Analogs

专利号:US-6506782-B1
优先权日:1998-02-27
标 题 :Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds