CAS: 1885-38-7; (E)-3-Phenylacrylonitrile

上下游产品

3-苯基丙-2-烯腈 (Z)-Cinnamonitrile 24840-05-9
顺-β-甲基苯乙烯 Cis-1-Phenyl-1-Propylene 766-90-5
甲基苯乙烯 1-Propenylbenzene 873-66-5
肉桂基胺 (E)-Cinnamylamine 4360-51-4
反式肉桂醛 (E)-3-Phenylpropenal 14371-10-9
肉桂醛 3-Phenyl-Propenal 104-55-2
3-苯基丙-2-烯-1-醇 (2E)-3-Phenyl-2-Propen-1-Ol 4407-36-7
肉桂基氯 Cinnamyl Chloride 21087-29-6 (E)-2-Bromo-3-Phenylacrylonitrile 19522-37-3 (Z)-2-Bromo-3-Phenylacrylonitrile 19522-36-2

反式肉桂醛置于吡啶,N-(2,2,6,6-Tetramethyl-1-Oxopiperidin-1-Ium-4-yl)Acetamide Tetrafluoroborate体系中,用 二氯甲烷 用作溶剂,化学反应 2.08H,反应生成肉桂腈
参考文献:含氧铵盐介导的醛类与腈的接触
标题:含氧铵盐介导的醛类与腈的接触
摘要:一种可扩展,高产,快速的途径,可通过乙氧基铵盐(4-乙酰氨基-2-2,2,6,6-四甲基哌啶-1-氟肟酸四氟硼酸)和六甲基二硅氮烷(hmds)介导的醛类中的一系列腈的进入已经被开发出来.该反应可能涉及两个不同的化学转化:Hmds和醛之间可逆的甲硅烷基亚胺形成,然后由氧铵盐介导的氧化和甲硅烷基化反应制得腈.废氧化剂可以容易地回收并用于再生氧铵盐氧化剂.
Doi:10.1002/anie.201412256

专利信息

专利号:EP-2647639-A1
优先权日:2012-04-06
标题:ß-boration of alkene and alkyne intermediates
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic chemistry, and in particular to the preparation of β-borated compounds. These β-borated compounds can be used as intermediates in the synthesis of pharmaceutically active agents such as Sitagliptin.

专利号:EP-2647640-A1
优先权日:2012-04-06
标 题:ß-boration of alkene and alkyne intermediates
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic chemistry, and in particular to the preparation of β-borated compounds. These β-boated compounds can be used as intermediates in the synthesis of pharmaceutically active agents such as Sitagliptin.

专利号:US-7034163-B2
优先权日:2003-09-05
标 题 :Synthesis of pyrroles
发明人：PAGENKOPF BRIAN L; YU MING
权利人:UNIV TEXAS
摘要:An improved and highly efficient method for the preparation of 2-R(R=alkyl, aryl, H) pyrroles from nitrites (RCN, R=alkyl, aryl) is described using Lewis acid activated donor-acceptor cyclopropanes to react with aliphatic, aromatic, branched, α,β-unsaturated, or otherwise functionalized nitrites in a cascade [3+2] dipolar cycloaddition, dehydration and tautomerization sequence.

专利号:US-9045573-B2
优先权日:2012-05-23
标题 :Solid-phase support for oligonucleotide synthesis and oligonucleotide synthesis method
发明人：MAETA ERI; MORI KENJIRO; MIWA KAZUYA
权利人:NITTO DENKO CORP
摘要:The present invention provides a solid-phase support for oligonucleotide synthesis for synthesizing long chain oligonucleotide, RNA oligonucleotide and modified oligonucleotide at high synthetic quantity and high purity with a low loading amount of a linker. Provided is a solid-phase support for oligonucleotide synthesis comprising a porous resin bead having a monovinyl monomer unit, a crosslinkable vinyl monomer unit and a polyethylene glycol unit and a cleavable linker loaded on its surface, n the porous resin bead having a group capable of binding to a carboxy group by a dehydration condensation reaction on its surface, the cleavable linker having a carboxy group, wherein the carboxy group of the cleavable linker is bound to the group capable of binding to a carboxy group, by a dehydration condensation reaction, andn na loading amount of the cleavable linker is 1 to 80 μmol/g relative to the weight of the porous resin bead.

专利号:US-2001053862-A1
优先权日:1998-12-22
标 题:Process for preparing arylpiperidine carbinol intermediates and derivatives
发明人：RONSEN BRUCE; UPADHYAYA SUBHASH P
摘要:A process for the synthesis of arylpiperidine carbinol intermediates and derivatives is disclosed. A preferred process embodiment provides the synthesis of intermediate compounds of structural formula (I) and structural formula (II): n n n where X is halo, C 1 -C 10 alkoxy, C 1 -C 10 haloalkyl, or hydroxy; R 2 and R 3 are each C 1 -C 4 alkyl, and R 2 and R 3 are the same. The compound of structural formula (I) is made by condensing a corresponding cinnamonitrile with a corresponding diester malonate. The compound of structural formula (II) in the (±)-trans configuration is obtained by hydrogenating the compound of structural formula (I). The compounds of structural formula (I) and structural formula (II) are useful chemical intermediates for synthesizing 4-arylpiperidine-3-carbinols and their derivatives in (−)-trans configuration.

专利号:WO-0037443-A1
优先权日:1998-12-22
标 题 :Process for preparing arylpiperidine carbinol intermediates and derivatives
发明人：RONSEN BRUCE; UPADHYAYA SUBHASH P
权利人:PENTECH PHARMACEUTICALS INC
摘要:A process for the synthesis of arylpiperidine carbinol intermediates and derivatives is disclosed. A preferred process embodiment provides the synthesis of intermediate compounds of structural formula (I) and structural formula (II), where X is halogen, C1-C10 alkyl, C1-C10 alkoxy, C1-C10 haloalkyl, hydroxy, or hydrogen; and R2 and R3 each is C1-C4 alkyl and R2 and R3 are the same. The compound of structural formula (I) is made by condensing a corresponding cinnamonitrile with a corresponding diester malonate. The compound of structural formula (II) in the (±)-trans configuration is obtained by hydrogenating the compound of structural formula (I). The compounds of structural formula (I) and structural formula (II) are useful chemical intermediates for synthesizing 4-arylpiperidine-3-carbinols and their derivatives in (-)-trans configuration.