CAS: 20018-09-1; 1-((Diiodomethyl)Sulfonyl)-4-Methylbenzene
该化合物是一种有机硫化合物,其特点是附于p-tolyl(par-ephony-p-ephony)和两个碘原子的磺酰胺组,该化合物一般是一种固体,由于碘原子的存在,可参与各种替代反应,因而具有反应性,因此具有反应性.全氟辛烷磺酸功能组有助于其极地性质,提高其在极地溶剂中的溶性.二碘甲基p-tolyl磺酸经常用于有机合成,特别是用于制作其他化学化合物,因为其具有作为磺酰胺剂的作用.此外,该化合物可能展示生物活动,使其对医药化学具有兴趣.在处理该化合物时,应注意安全防范措施,因为它可能构成健康风险,包括潜在的毒性.适当的储存和处置方法对于减轻环境影响和确保实验室环境中的安全至关重要.
- 英文名称1-((Diiodomethyl)Sulfonyl)-4-Methylbenzene
- 中文名称4-甲苯基-二碘甲基砜
- IUPAC名称1-((diiodomethyl)sulfonyl)-4-methylbenzene
- 其它别名Diiodomethyltolylsulfone [inci]; 4-(Diiodomethylsulfonyl) Toluene; P-[(Diiodomethyl)Sulphonyl]Toluene; Fdj36Qmi3H; Amical 48; Diiodomethyl P-Tolyl Sulphone; Diiodomethyl P-Tolyl Sulfone
- CAS编号20018-09-1
- MFCD编号:MFCD00072720
- EINECS号:243-468-3
- FDA UNII编号:FDJ36QMI3H
- 分子式:C8H8I2O2S
- 分子量:422.02
- 产品CID: 1017506
- 产品分类化学试剂 → 有机试剂 → 砜,亚砜类化合物
物理性质
MSDS等安全信息
- GHS象形图
- GHS符号GHS06 & GHS05 & GHS09;
注释: Skull and crossbones & Corrosion & Environment - 危险类别急性毒性 类别3(吸入)
严重眼损伤 类别1
水生急性毒性 类别1
水生慢性毒性 类别1
皮肤致敏 类别1
特定目标器官毒性-重复接触 类别2
急性毒性 类别2(吸入)
生殖毒性 类别2
皮肤腐蚀/刺激 类别2 - 警示词Danger(危险)
- 危险描述H331 |吸入会中毒.
H318 |造成严重眼损伤.
H400 |对水生生物毒性极大.
H410 |对水生生物毒性极大并具有长期持续影响.
H317 |可能引起皮肤过敏反应.
H373 |长期或反复接触可能损害器官.
H330 |吸入致命.
H361fd |怀疑会影响生育能力. 怀疑对胎儿造成损害.
H315 |造成皮肤刺激. - 防范说明P261-P271-P304+P340-P311-P321-P403+P233-P405-P501-P280-P305+P351+P338-P310-P273-P391-P501
- 危险品标志Xi
- 安全声明IDENTIFICATION AND USE: Diiodomethyl p-tolyl sulfone (DIMPTS) is a tan powder at room temperature. It is an algaecide, bactericide, and fungicide. DIMPTS is used as a materials preservative in paints, air duct coatings, fire-retardant coatings, pigment dispersions, inks, emulsions, extender slurries, adhesives, caulks, sealants, rubbers, plastic, textiles, leather, paper production to protect pulp and slurries, paper/paperboard, and wetlap. It is also used as a wood preservative. HUMAN EXPOSURE AND TOXICITY: Corrosive: causes irreversible eye damage. Harmful if absorbed through the skin. ANIMAL STUDIES: Male and female rats and dogs were administered DIMPTS for 90-days via the diet. In rats, the only treatment-related finding was squamous metaplasia of the salivary gland duct in the 80 mg/kg/day group. In dogs, female body weights in the high-dose group were significantly lower than controls. Altered clinical pathology parameters were considered secondary to inflammatory changes observed in some of the dogs. Treatment-related alterations were found in the thyroid glands, salivary glands, GI-tract in the mid- and/or high-dose groups. DIMPTS was negative in the four in vitro and one in vivo genotoxicity assays. The toxicological effects noted in the two mammalian species are consistent with the principal toxic effects of iodide, and are proposed to arise from release of iodide from the DIMPTS molecule with toxic sequelae. DIMPTS caused dystocia, decreased neonatal survival and hypothyroidism in rat reproduction studies resembling the effects caused by iodide. One molecule of DIMPTS contains two iodine moieties that are hydrolyzed upon ingestion and systemically absorbed, suggesting iodide toxicity as a probable mode of action for the effects observed in rats. Female rats given DIMPTS had increased incidence of vulvar discharge and dystocia, decreased litter size, decreased body weights and feed consumption, increased thyroid weights, thyroid follicular cell hypertrophy with decreased colloid, decreased triiodothyronine, and increased thyroid stimulating hormone levels. DIMPTS pups had decreased neonatal survival and body weights. These effects were associated with elevated levels of iodide in milk and sera. In contrast, DIMPTS de-iodinated analogue did not produce similar effects in adult females or their offspring. In rats reproductive toxicity at 40 mg/kg/day consisted of increased post implantation loss, decreased gestation survival and two cases of dystocia, while litter size, pup survival/weight were affected at 10 and 40 mg/kg/day. Morphological examinations of fetuses revealed no evidence of teratogenesis.
- 危险类别码In animal studies: corrosive to eyes, mild to moderate skin irritant, and not a skin sensitizer; Developmental and reproductive effects observed in rats at doses highly toxic to the mothers; The release of iodine is associated with dystocia, changes in parental thyroid and pituitary, and decreased survival and weights of offspring; Thyroid effects in animal studies include degeneration in 90-day study of dogs and histopathological changes in rat reproductive studies; [Reference #1]
欧盟法规
ECHA物质C&L通报欧盟生物杀灭剂法规欧盟《生物杀灭剂法规》REACH预注册合成工艺路线路线简述
海关参考信息
- 2902300000-甲苯
2930909099-其他有机硫化合物
2904990090-其他烃的磺化、硝化、亚硝化衍生物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2011230343-A1
优先权日:2008-10-24
标题 :Method for the Manufacture of Microparticles Comprising an Effect Substance
发明人：SCHROERS MICHAEL; DYLLICK-BRENZINGER RAINER; MERK MICHAEL; BARG HEIKO
权利人:BASF SE
摘要:A subject matter of the present invention is a process for the preparation of effect compound-comprising microparticles M comprising A) the formation of a crude suspension of microparticles A by means of enzymatic polyester synthesis in an inverse miniemulsion comprising enzyme, effect compound and polyester monomers; and B) the polymerization of wall monomers from the group consisting of ethylenically unsaturated monomers, polyisocyanates and polyepoxides in the crude suspension of microparticles A. Furthermore, the present invention relates to microparticles M which can be obtained by means of the process according to the invention and also to an agrochemical formulation comprising microparticles M. In addition, the present invention relates to the use of microparticles M prepared according to the invention as component in colorants, cosmetics, drugs, biocides, plant protection agents, fertilizers, additives for food or animal fodder, or auxiliaries for polymers, paper, textiles, leather, detergents or cleaners. Finally, the invention also relates to a method for combating undesirable plant growth, to a method for combating undesirable insect or acarid infestation on plants and/or for combating phytopathogenic fungi, and to seeds treated with the agrochemical formulation.
专利号:US-2004043959-A1
优先权日:2002-03-04
标 题 :Combination therapies for treating methylthioadenosine phosphorylase deficient cells
发明人：BLOOM LAURA A; BORITZKI THEODORE J; OGDEN RICHARD; SKALITZKY Donald; KUNG PEI-PEI; ZEHNDER LUKE; KUHN LESLIE; MENG JERRY JIALUN
摘要:The present invention is directed to combination therapies for treating cell proliferative disorders associated with methylthioadenosine phosphorylase (MTAP) deficient cells in a mammal. The combination therapies selectively kill MTAP-deficient cells by administering an inhibitor of de novo inosinate synthesis and administering an anti-toxicity agent, wherein the inhibitors of de novo inosinate synthesis are inhibitors of glycinamide ribonucleotide formyltransferase (“GARFTâ€?) and/or aminoinidazolecarboximide ribonucleotide formyltransferase (“AICARFTâ€?), and the anti-toxicity agent is an MTAP substrate (e.g. methylthioadenosine or “MTAâ€?), a precursor of MTA, an analog of an MTA precursor or a prodrug of an MTAP substrate.
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供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
摘要:US EPA; Estimation Program Interface (EPI) Suite. Ver. 4.11. Nov, 2012. Available from, as of March 2, 2016:
摘要:USEPA; Reregistration Eligibility Decision, Diiodomethyl p-tolyl sulfone p.6 EPA 739-R-08-002 (March 2008). Available from, as of January 13, 2016:
摘要:Lewis, R.J. Sr. (ed) Sax's Dangerous Properties of Industrial Materials. 12th Edition. Wiley-Interscience, Wiley & Sons, Inc. Hoboken, NJ. 2012., p. 1638
摘要:Franke C et al; Chemosphere 29: 1501-14 (1994)
摘要:USEPA/Office of Prevention, Pesticides and Toxic Substances; Reregistration Eligibility Decision Document for Diiodomethyl p-tolyl sulfone p.52 EPA 739-R-08-002 (March 2008). Available from, as of April 4, 2016: https://www.epa.gov/pesticides/reregistration/status.htm
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尽可能描述清楚需求与问题信息
