CAS: 27514-08-5; N-(4-Oxocyclohexyl)Acetamide

相似化合物

27489-60-7 23363-88-4 1353971-70-6

上下游产品

CAS号23363-88-4 4-乙酰氨基环己醇 | CAS号103-90-2 对乙酰氨基苯酚 | CAS号27489-60-7 反-4-乙酰氨基环己醇 | CAS号27489-62-9 反式-4-氨基环己醇 | CAS号90978-87-3 4-乙酰胺-乙酸环己酯 | CAS号142080-48-6 2-((4-acetamido... | CAS号106006-83-1 2,6-二氨基-4,5,6,7... | CAS号97096-16-7 8-氨基-1,4-二氧杂螺[4,5]癸烷 | CAS号104632-25-9 盐酸普拉克索 | CAS号104632-26-0 普拉克索 | CAS号106092-09-5 (S)-2,6-二氨基-4,5... | CAS号106006-84-2 s-2-氨基-6-丙酰氨基-4... | CAS号687639-03-8 2-溴-4-乙酰氨基环己酮 | CAS号60480-69-5 3-乙酰氨基-1,2,3,4-四氢咔唑

对乙酰氨基酚置于palladium On Activated Charcoal,氢气体系中,用 Aq. Acetate Buffer 用作溶剂,105.0 °C,600.01 Kpa 条件下,反应生成4-乙酰氨基环己酮
参考文献:克服制药生产中液相pd / C介导的催化加氢的规模化和规模化问题
标题:克服制药生产中液相pd / C介导的催化加氢的规模化和规模化问题
摘要:通过液相pd / C介导的加氢工艺扩大规模和生产中间体或前体药物的实用解决方案可能引起广泛关注,即使由于专利法规而没有成为先前发表的研究重点,也应引起广泛关注法.实际的障碍是持久存在的,并且已为人所知很长时间,但大部分仍未公布.促成药物生产成功扩大加氢的最重要发现和解决方案如下:(i)fe 2+对pd / C催化剂的毒化离子,用于将2,6-二甲基-1-亚硝基哌啶选择性加氢为相应的hydr唑化合物;(II)将沉积的pd金属与cu合金化以将芳族酰氯转化为相应的醛;(III)将反应混合物的ph值改变为碱性值,以增强对乙酰氨基酚氢化的立体选择性;(iv)对催化剂制备方法的有用修改,即催化剂的酸化导致苄基oh在含碱性n原子的分子中的氢解;(v)使用两个液相,一共是四相系统,这使得潜在的催化剂中毒分子中的s-s键发生氢解;(vi)通过使反应混合物用氢饱和来保持催化剂的金属pd表面,导致高h2 /底物比
Doi:10.1021/acs.Oprd.6B00073

专利信息

专利号:WO-2010078250-A1
优先权日:2008-12-30
标 题:Synthesis of (2-amino)-tetrahydrocarbazole-propanoic acid
发明人：WEI YUAN; Li tianqiao; CHI YONGXIANG; ZHU JINGYANG
权利人:CHIRAL QUEST INC; WEI YUAN; Li tianqiao; CHI YONGXIANG; ZHU JINGYANG
摘要:The present invention provides a new approach to the synthesis of 2-amino-tetrahydrocarbazole-propanoic acid, a key intermediate for the synthesis of Ramatroban. More specifically, a synthesis of 2-amino-tetrahydrocarbazole- propanoic acid which includes oxidizing an aminocyclohexanol to form an aminocyclohexanone, condensing the aminocyclohexanone to form a tetrahydrocarbazole, deprotecting the tetrahydrocarbazole to yield a racemic mixture of a tetrahydrocarbazole, resolving the racemic mixture to obtain a yield mixture with an enantiomeric excess of one enantiomer over another, alkylating the excess enantiomer to yield an alkyl ester, and hydrolyzing the alkyl ester to yield 2-amino-tetrahydrocarbazole-propanoic acid.

专利号:US-8003785-B2
优先权日:2008-06-18
标 题 :Halo-substituted pyrimidodiazepines
发明人：CAI JIANPING; CHEN SHAOQING; CHU XIN-JIE; LUK KIN-CHUN; MISCHKE STEVEN GREGORY; SUN HONGMAO; WOVKULICH PETER MICHAEL
权利人:TAKEDA PHARMACEUTICAL
摘要:The present invention provides PLK1 inhibitor compounds of formula I: n nuseful in the treatment or control of cell proliferative disorders, particularly oncological disorders. These compounds and formulations containing such compounds may be useful in the treatment or control of solid tumors, such as, for example, breast, colon, lung and prostate tumors and other oncological diseases such as non-Hodgkin's lymphomas. Also provided are intermediate compounds useful in the synthesis of compounds of formula I.

专利号:CN-1772744-A
优先权日:2004-11-12
标题:Synthesis of (-)-2-amino-6-propionamido tetrahydro benzothiazole

专利号:GB-2394951-A
优先权日:2002-11-04
标题 :One pot synthesis of 2,6-diamino-4,5,6,7-tetrahydro-benzothiazole

专利号:CN-111018805-A
优先权日:2019-12-26
标 题 :Synthesis and separation method of pramipexole intermediate

专利号:CN-119707712-A
优先权日:2024-12-06
标题 :A kind of synthesis process of trans-p-aminocyclohexanol