CAS: 36051-68-0; Sodium ((2R,3S,4R,5R)-5-(4-Amino-2-Oxopyrimidin-1(2H)-yl)-3,4-Dihydroxytetrahydrofuran-2-yl)Methyl Dihydrogentriphosphate

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81012-87-5 34393-59-4 65-47-4

专利信息

专利号:EP-2235177-B1
优先权日:2008-06-13
标 题 :Method for enzymatic synthesis of chemically modified rna
发明人：ROHAYEM JACQUES
权利人:RIBOXX GMBH
摘要:The present invention relates to a method for enzymatically synthesizing chemically modified RNA by using RNA-dependent RNA polymerases (RdRp), especially RdRps from viruses of the Caliciviridae family. The method of the present invention is particularly useful for preparing RNA molecules of increased stability especially with respect to RNA degradation, for example for in vivo applications. Further subject matter of the present invention relates to a kit for carrying out the enzymatic synthesis of the chemically modified RNA.

专利号:US-10736912-B2
优先权日:2005-05-23
标 题 :Compositions containing PUFA and/or uridine and methods of use thereof
发明人：WURTMAN RICHARD; RICHARDSON INGRID
权利人:MASSACHUSETTS INSTITUE OF TECH; MASSACHUSETTS INST TECHNOLOGY
摘要:This invention provides methods of enhancing brain development; increasing or enhancing intelligence; increasing or enhancing synthesis and levels of phospholipids, synapses, synaptic proteins, and synaptic membranes by a neural cell or brain cell, comprising contacting a subject or a pregnant or nursing mother thereof with a composition comprising an omega-3 fatty acid, an omega-6 fatty acid, and/or uridine, a metabolic precursor thereof, or a combination thereof.

专利号:US-2022356497-A1
优先权日:2019-06-26
标 题 :Compositions and methods for synthesis of terpenoids
发明人：DE KOK STEFAN; LAU WARREN; MCSORLEY FERN; MEYER HERMANN-JOSEF; SERBER ZACH; WAWRZYN GRAYSON
权利人:ZYMERGEN INC
摘要:The disclosure relates to the biosynthesis of terpenoids, such as, for example, geraniol and derivatives thereof, using genetic engineering. In particular, the disclosure relates to the biosynthesis of nepetalactol, nepetalactone, dihydronepetalactone, and derivatives thereof. The disclosure provides recombinant cells genetically engineered to produce high levels of nepetalactol, nepetalactone and/or dihydronepetalactone. The disclosure also provides methods of producing nepetalactol, nepetalactone and dihydronepetalactone using cell-based systems as well as cell-free systems.

专利号:US-2024409571-A1
优先权日:2023-06-08
标 题:Chemoenzymatic synthesis of n-acetylated gangliosides and glycosphingosines
发明人：CHEN XI; YU HAI; MISHRA BIJOYANANDA; ZHENG ZIMIN; AGRAHARI ANAND KUMAR; GUCCHAIT ARIN
权利人:UNIV CALIFORNIA
摘要:Described herein are novel stable 9-N-, 8-N-, and 7-N-acetyl analogues of instable 9-O-acetyl, 8-O-acetyl, and 7-O-acetyl b-series gangliosides and glycosphingosines, including GD3, GD2, GD1b, GT1b, GQ1b, and their glycosphingosines. Chemoenzymatic methods for the production of the stable 9-N-, 8-N-, and 7-N-acetyl analogues are also described herein.

专利号:US-6319695-B1
优先权日:1991-10-15
标 题:Production of fucosylated carbohydrates by enzymatic fucosylation synthesis of sugar nucleotides; and in situ regeneration of GDP-fucose
发明人：WONG CHI-HUEY; ICHIKAWA YOSHITAKA; SHEN GWO-JENN; LIU KUN-CHIN
权利人:SCRIPPS RES INSITUTE
摘要:This invention contemplates improved methods of enzymatic production of carbohydrates especially fucosylated carbohydrates. Improved syntheses of glycosyl 1- or 2-phosphates using both chemical and enzymatic means are also contemplated. The phosphorylated glycosides are then used to produce sugar nucleotides that are in turn used as donor sugars for glycosylation of acceptor carbohydrates. Especially preferred herein is the use of a disclosed method for fucosylation.

专利号:US-2002142422-A1
优先权日:1999-12-16
标 题 :Moss genes from physcomitrella patens encoding proteins involved in the synthesis of amino acids, vitamins, cofactors, nucleotides and nucleosides
发明人：LERCHL JENS; RENZ ANDREAS; EHRHARDT THOMAS; REINDL ANDREAS; CIRPUS PETRA; BISCHOFF FRIEDRICH; FRANK MARKUS; FREUND ANNETTE; DUWENIG ELKE; SCHMIDT RALF-MICHAEL; RESKI RALF
摘要:Isolated nucleic acid molecules, designated MP protein nucleic acid molecules, which encode novel MP proteins from e.g. Phycomitrella patens are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MP protein nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MP proteins, mutated MP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from transformed cells, organisms or plants based on genetic engineering of MP protein genes in these organisms.