CAS: 40216-83-9; H-Hyp-Ome.Hcl

相似化合物

114676-59-4 481704-21-6 102195-79-9

上下游产品

CAS号67-56-1 甲醇 | CAS号51-35-4 L-羟脯氨酸 | CAS号75-36-5 乙酰氯 | CAS号13726-69-7 B°C-L-羟脯氨酸 | CAS号32968-78-8 反式-4-羟基-L- 脯氨酸盐酸盐 | CAS号77-76-9 2,2-二甲氧基丙烷 | CAS号364750-80-1 (2S,4R)-1-(叔丁氧羰... | CAS号487048-28-2 顺式-N-b°C-4-氰基-l... | CAS号194163-91-2 反式-N-B°C-4-氰基-L... | CAS号426844-76-0 (2S,4S)-1-B°C-2... | CAS号215918-21-1 (2S)-4,4-二氟-2-(... | CAS号191280-88-3 1-N-B°C-(2S,4S)... | CAS号179990-59-1 (4R, 2S)-4-Hydr... | CAS号88043-21-4 N-B°C-反式-4-对甲苯磺... | CAS号83548-46-3 N-B°C-L-脯氨酸-4-烯甲基酯 | CAS号31560-20-0 反-1-苯甲酰-4-羟基-L-脯氨酸甲酯

N-Boc-反式-4-羟基-L-脯氨酸甲酯置于盐酸体系中,用 1,4-二氧六环 作为反应溶剂,化学反应 3.0H,反应生成 反式-4-羟基-L-脯氨酸甲酯盐酸盐
参考文献:Pyrrole Compounds As Granzyme B Inhibitors
标题:Pyrrole Compounds As Granzyme B Inhibitors
摘要:吡咯化合物作为粒酶b抑制剂,包括这些化合物的组合物以及使用这些化合物的方法.提供了一种治疗皮肤硬化病,大疱性表皮松解症,放射性皮炎,斑秃和蝶形红斑狼疮的方法.

专利信息

专利号:US-8829184-B2
优先权日:2010-04-15
标题:Intermediates useful for the synthesis of pyrrolobenzodiazepines
发明人：HOWARD PHILIP WILSON; MASTERSON LUKE; TIBERGHIEN ARNAUD
权利人:HOWARD PHILIP WILSON; MASTERSON LUKE; TIBERGHIEN ARNAUD; SPIROGEN SARL
摘要:A compound of formula (I): which is substantially free of any of the corresponding compound of formula (IB): methods of making such compounds, and the further transformation of such compounds.

专利号:US-2012095211-A1
优先权日:2010-09-22
标 题 :Substituted proline inhibitors of hepatitis c virus replication
发明人：BUCKMAN BRAD; NICHOLAS JOHN B; SEREBRYANY VLADIMIR; SEIWERT SCOTT D
权利人:BUCKMAN BRAD; NICHOLAS JOHN B; SEREBRYANY VLADIMIR; SEIWERT SCOTT D; INTERMUNE INC
摘要:The embodiments provide compounds of the general Formulae I, Ia, II, IIa, III, IIIa, IIIb, IV, IVa, IVb, V, Va, Vb, VI, VIa, VIb, and VIc, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition. The embodiments also provide methods for the synthesis of subject compounds and intermediates in the synthetic methods.

专利号:US-2024124938-A1
优先权日:2019-10-16
标题:Visual detection of pbd induced dna crosslinks
发明人：LACHAUD CHRISTOPHE; COMBES SÉBASTIEN; ABEL SÉBASTIEN; AUDOLY GILLES; BERRADA SARA
权利人:INST NAT SANTE RECH MED; INST JEAN PAOLI & IRENE CALMETTES; AIX MARSEILLE UNIV; CENTRE NAT RECH SCIENT
摘要:The present invention relates to the field of oncology. laboratory tools and methods, and especially anti-tumor DNA crosslinking agents. Most patients with advanced solid tumors develop resistance to chemotherapy due to the ability of cancer cells to repair or tolerate sustained DNA damages. The inventors showed that the compounds according to the present invention allow the detection and visualization of alkylated DNA damages induced by PBDs without altering their DNA crosslinking ability. This enables the study of the effect and properties of PBDs. In particular, the present invention relates new derivates of PBD molecules and their synthesis. The present invention also relates to a method for visualizing DNA crosslinking: to a method for assessing the resistance of a tumor to a crosslinking agent and to a method for identifying a molecule or treatment for improving the efficiency of a crosslinking agent.

专利号:US-2013035484-A1
优先权日:2010-04-15
标 题:Intermediates useful for the synthesis of pyrrolobenzodiazepines

专利号:CN-109957566-B
优先权日:2017-12-26
标 题 :Modified oligonucleotides and compounds useful in the synthesis of modified oligonucleotides

专利号:CN-109957566-A
优先权日:2017-12-26
标 题 :Modified oligonucleotides and compounds useful in the synthesis of modified oligonucleotides