CAS: 452-86-8; 4-Methylbenzene-1,2-Diol

上下游产品

CAS号108-39-4 间甲酚 | CAS号106-44-5 对甲酚 | CAS号93-51-6 2-甲氧基-4-甲基苯酚 | CAS号7145-99-5 5-甲基苯并[d][1,3]二氧杂环戊烷 | CAS号1121-69-3 lithium 4-methy... | CAS号3131-54-2 4-methylcyclohe... | CAS号33632-37-0 7-methyl-3,4-di... | CAS号139-85-5 原儿茶醛; 原二茶醛; 茶酚甲... | CAS号2833-21-8 (E)-4-OXO-PENT-... | CAS号541-50-4 3-氧丁酸 | CAS号3897-89-0 3,4-二羟基苄醇 | CAS号144-62-7 草酸 | CAS号494-99-5 3,4-二甲氧基甲苯 | CAS号93-51-6 2-甲氧基-4-甲基苯酚 | CAS号152272-65-6 2-chloro-5-meth... | CAS号4434-13-3 5-甲基-2-甲酸吡啶 | CAS号3131-54-2 4-methylcyclohe... | CAS号50-53-3 氯丙嗪

乙酸间甲苯酯置于sodium Hydroxide,三氯化铝,双氧水体系中,化学反应生成 3,4-二羟基甲苯
参考文献:Synthesis Of Vanillin From Cresols. I. Synthesis Of Homopyrocatechin
标题:Synthesis Of Vanillin From Cresols. I. Synthesis Of Homopyrocatechin
摘要:
DOI:10.1246/bcsj.11.127

专利信息

专利号:US-5362899-A
优先权日:1993-09-09
标题:Chiral synthesis of alpha-aminophosponic acids
发明人：CAMPBELL DAVID A
权利人:AFFYMAX TECH NV
摘要:A stereospecific method of preparing alpha-aminophosphonic acids and derivatives thereof is provided. A protected amino acid is converted to a acyl aroyl or diacyl peroxide which spontaneously rearranges to form an alpha-amino ester. This rearrangement occurs stereospecifically with retention of configuration. The ester is subsequently converted to an appropriate leaving group and displaced with a phosphite yielding a chiral alpha-aminophosphonic acid or derivative. n Alpha-aminophosphonic acids are useful for the synthesis of peptide analogs that possess a phosphonate linkage in the place of an amide linkage. This substitution can impart protease resistance in therapeutic peptides thereby increasing the serum half-life.

专利号:US-2004101523-A1
优先权日:1989-07-27
标题:Renal-selective prodrugs for control of renal smpathetic nerve activity in the treatment of hypertension
发明人：REITZ DAVID B; KOEPKE JOHN P; BLAINE EDWARD H; SCHUH JOSEPH R; MANNING ROBERT E; SMITS GLENN J
权利人:SEARLE & CO
摘要:Renal-selective prodrugs are described which are preferentially converted in the kidney to compounds capable of inhibiting synthesis of catecholamine-type neurotransmitters involved in renal sympathetic nerve activity. The prodrugs described herein are derived from inhibitor compounds capable of inhibiting one or more of the enzymes involved in catecholamine synthesis, such compounds being classifiable as tyrosine hydroxylase inhibitors, or as dopa-decarboxylase inhibitors, or as dopamine-β-hydroxylase inhibitors. These inhibitor compounds are linked to a chemical moiety, such as a glutamic acid derivative, by a cleavable bond which is recognized selectively by enzymes located predominantly in the kidney. The liberated inhibitor compound is then available in the kidney to inhibit one or more of the enzymes involved in catecholamine synthesis. Inhibition of renal catecholamine synthesis can suppress heightened renal nerve activity associated with sodium-retention related disorders such as hypertension. Conjugates of particular interest are glutamyl derivatives of dopamine-β-hydroxylase inhibitors, of which N-acetyl-γ-glutamyl fusaric acid hydrazide (shown below) is preferred.

专利号:US-2024124910-A1
优先权日:2021-02-02
标题:Ribosome-mediated polymerization of novel chemistries
发明人：JEWETT MICHAEL CHRISTOPHER; LEE JOONGOO; ANSLYN ERIC V; CORONADO JAIME; LIM JONGDOO
权利人:UNIV NORTHWESTERN; UNIV TEXAS
摘要:Disclosed are methods, systems, components, and compositions for synthesis of sequence defined polymers. The methods, systems, components, and compositions may be utilized for incorporating novel substrates that include non-standard amino acid monomers and non-amino acid monomers into sequence defined polymers. As disclosed herein, the novel substrates may be utilized for acylation of tRNA via flexizyme catalyzed reactions. The tRNAs thus acylated with the novel substrates may be utilized in synthesis platforms for incorporating the novel substrates into a sequence defined polymer.

专利号:US-6242602-B1
优先权日:1999-03-29
标 题:One pot synthesis of 5,10-dihydrophenazine compounds and 5,10-substituted dihydrophenazines
发明人：GIRI PUNAM; BYKER HARLAN J; BAUMANN KELVIN L
权利人:GENTEX CORP
摘要:Dihydrophenazines and bis(dihydrophenazines) are prepared in high yield under commercially viable reaction conditions by reacting a catechol with a 1,2-diaminoaryl compound, wherein either the catechol or the 1,2-diaminoaryl compound is provided in at least 50% molar stoichiometric excess. The product may be oxidized to the corresponding phenazine, but is preferably derivatized at one or both of the 5,10-positions to form a monosubstituted or disubstituted dihydrophenazine or bis(dihydrophenazine). Most preferably, 5,10-dialkyl-5,10-dihydrophenazines are prepared starting from catechol and 1,2-diaminoaryl compound in a one pot synthesis. The products are useful as dyes, and in particular as chromophores in electrochromic systems.

专利号:US-2013331427-A1
优先权日:2006-07-28
标题:Methods of stimulating cellular growth, synaptic, remodeling and consolidation of long-term memory
发明人：ALKON DANIEL L
权利人:BRNI NEUROSCIENCES INST; BRNI NEUROSCIENCES INST
摘要:The present invention provides methods of slowing or reversing the loss of memory and learning comprising the steps of contacting an effective amount of a PKC activator with a protein kinase C (PKC) in a subject identified with memory loss slowing or reversing memory loss. The present invention provides methods of stimulating cellular growth, neuronal growth, dendritic growth, dendritic spine formation, dendritic spine density, and the translocation of ELAV to proximal dendrites, and synaptic remodeling. The present invention also provides methods of contacting a protein kinase C (PKC) activator with a PKC activator in a manner sufficient to stimulate the synthesis of proteins sufficient to consolidate long-term memory. The present invention also provides methods of contacting a protein kinase C (PKC) activator with a PKC activator in a manner sufficient to downregulate PKC.

专利号:US-2009099061-A1
优先权日:2006-01-27
标 题:Synthesis of carotenoid analogs or derivatives with improved antioxidant characteristics
发明人：FOSS BENTE J; NADOLSKI GEOFFRY T; LOCKWOOD SAMUEL F
权利人:FOSS BENTE J; NADOLSKI GEOFFRY T; LOCKWOOD SAMUEL F
摘要:A method is described for synthesizing and administering carotenoid compounds with improved antioxidant characteristics. In some embodiments, extension or improvement of conjugation may be employed in structural modification of carotenoids. In other embodiments, reduction of ring/chain steric hindrance may improve the lambda max, and hence, the overall antioxidant capability, of particular compounds. In other embodiments, introduction and/or increase in synthetic handles for conjugation may improve the stoichiometric ratios of conjugating moieties to the polyene backbone. The methods may be used to improve natural and/or synthetic compounds for medicinal application in the treatment of disease.