CAS: 455-87-8; 4-Amino-3-Fluorobenzoic Acid

上下游产品

CAS号403-21-4 3-氟-4-硝基苯甲酸 | CAS号7439-89-6 铁粉 | CAS号446-34-4 3-氟-4-硝基甲苯 | CAS号713-11-1 4-乙酰氨基-3-氟苯甲酸 | CAS号352-70-5 3-氟甲苯 | CAS号326-67-0 N-(2-氟-4-甲基苯基)乙酰胺 | CAS号825-98-9 3-氟-4-碘苯甲酸

3-氟-4-氨基苯腈置于硫酸体系中,化学反应生成 3-氟-4-氨基苯甲酸
参考文献:一种3-氟-4-硝基苯甲酸的制备方法
标题:一种3-氟-4-硝基苯甲酸的制备方法
摘要:本发明涉及有机化学领域,特别是涉及一种3‑氟‑4‑硝基苯甲酸的制备方法,所述制备方法包括如下步骤:将3,4‑二氟苯腈与氨基取代试剂进行氨基取代反应,以使4位氟被氨基取代,通过短蒸或者精馏的方法将溶剂和4‑氨基‑3‑氟苯腈分离,将4‑氨基‑3‑氟苯腈与氰基水解试剂混合发生氰基水解反应,然后将氰基水解反应得到的水解产物体系与氧化试剂混合进行氰基水解反应,反应后经过后处理得到3‑氟‑4‑硝基苯甲酸,本申请的3‑氟‑4‑硝基苯甲酸的制备方法生产过程简洁,原子利用率高,安全性高,成本低,三废少.

专利信息

专利号:US-11773118-B2
优先权日:2019-02-21
标 题:Methods of making high enantioselective secondary alcohols
发明人：YU CHENG-DER TONY; HSIEH YIH-HUANG; LIN SHU-YI; CHAO CHIN-SHENG; HSIEH YIN-CHENG; LAI MING-TAIN
权利人:OBI PHARMA INC
摘要:A new process to synthesis of compound OBI-3424 R-form and S-form products is provided. The “R-formâ€? compound OBI-3423 was first synthesized with 48% overall yield from compound OBI-3424-5 by installation of the labile phosphate motif at later stage. The stereo chemistry is established by 5 steps chemo-enzyme combination synthesis to afford 99% optical purity. After then, the “S-formâ€? compound OBI-3424 is prepared with improving overall yield of 54% from compound OBI-3424-5. The stereo chemistry is established by 4 steps combination of chemo-enzyme synthesis with excellent optical purity of 99%.

专利号:US-8003785-B2
优先权日:2008-06-18
标 题 :Halo-substituted pyrimidodiazepines
发明人：CAI JIANPING; CHEN SHAOQING; CHU XIN-JIE; LUK KIN-CHUN; MISCHKE STEVEN GREGORY; SUN HONGMAO; WOVKULICH PETER MICHAEL
权利人:TAKEDA PHARMACEUTICAL
摘要:The present invention provides PLK1 inhibitor compounds of formula I: n nuseful in the treatment or control of cell proliferative disorders, particularly oncological disorders. These compounds and formulations containing such compounds may be useful in the treatment or control of solid tumors, such as, for example, breast, colon, lung and prostate tumors and other oncological diseases such as non-Hodgkin's lymphomas. Also provided are intermediate compounds useful in the synthesis of compounds of formula I.

专利号:EP-2968667-A1
优先权日:2013-03-14
标题:Peg-based adhesive phenylic derivatives and methods of synthesis and use

专利号:US-2016032047-A1
优先权日:2013-03-14
标题 :Peg-based adhesive phenylic derivatives and methods of synthesis and use

专利号:CA-2905840-A1
优先权日:2013-03-14
标题 :Peg-based adhesive phenylic derivatives and methods of synthesis and use

专利号:CN-104530439-A
优先权日:2014-12-25
标 题:Synthesis method of sulfonated polybenzimidazole-polyimide block copolymer proton exchange membrane material