CAS: 631-22-1; Diethyl Dibromomalonate

相似化合物

685-87-0 29263-94-3 609-13-2

上下游产品

溴代丙二酸二乙酯 Diethyl 2-Bromomalonate 685-87-0
Diethyl Bromochloromalonate 81289-78-3

丙二酸二乙酯置于lead(Iv) Acetate,Zinc Dibromide体系中,用 乙腈 作为反应溶剂,化学反应 3.5H,以86%的收率获得产物二溴丙二酸二乙酯
参考文献:亲核卤化物向亲电卤化物的转化:使用金属卤化物/四乙酸铅对吖嗪酮,酰胺和羰基化合物进行高效和选择性卤化
标题:亲核卤化物向亲电卤化物的转化:使用金属卤化物/四乙酸铅对吖嗪酮,酰胺和羰基化合物进行高效和选择性卤化
摘要:Alcl 3 /pb(Oac) 4 和znbr 2 /pb(Oac) 4 是有效的亲电子n-和α-C-卤化剂.使用在乙腈中的 Alcl 3 /pb(Oac) 4 和 Znbr 2 /pb(Oac) 4 对各种吖酮,酰胺和羰基化合物进行化学选择性和区域选择性 N-或 α-C-卤化,收率非常好至极好.
DOI:10.1055/s-2006-926224

专利信息

专利号:US-10294196-B2
优先权日:2015-11-18
标题:Process for the synthesis of intermediates useful for preparing 1,3,4-triazine derivatives
发明人：XU SHENG; XU YIHUI
权利人:FMC CORP
摘要:A process for the synthesis of 1,3-diethyl 2-(2-methylhydrazinylidene)propanedioate comprising the step of: reacting 2-halosubstituted diethyl malonate or mixtures of 2-halo-substituted diethyl malonates with methylhydrazine or the salt thereof in the presence of an acid catalyst is disclosed. 1,3-diethyl 2-(2-methylhydrazinylidene)propanedioate is an intermediate useful for preparing 1,3,4-triazines.

专利号:US-6825185-B2
优先权日:2000-12-21
标题:Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use
发明人：KHANAPURE SUBHASH P; GARVEY DAVID S; EARL RICHARD A; EZAWA MAIKO; FANG XINQIN; GASTON RICKY D
权利人:NITROMED INC
摘要:The invention describes novel substituted aryl compounds that are cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or, optionally, at least one therapeutic agent, such as, steroids, nonsterodal antiinflammatory compounds (NSAID), 5-lipoxygenase (5-LO) inhibitors, leukotriene B 4 (LTB 4 ) receptor antagonists, leukotriene A 4 (LTA 4 ) hydrolase inhibitors, 5-HT agonists, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) inhibitors, H 2 antagonists, antineoplastic agents, antiplatelet agents, thrombin inhibitors, thromboxane inhibitors, decongestants, diuretics, sedating or non-sedating anti-histamines, inducible nitric oxide synthase inhibitors, opioids, analgesics, Helicobacter pylori inhibitors, proton pump inhibitors, isoprostane inhibitors, and mixtures thereof. The invention also provides novel kits comprising at least one COX-2 selective inhibitor, and, optionally, at least one nitric oxide donor, and/or, optionally, at least one therapeutic agent. The novel cyclooxygenase 2 selective inhibitors of the invention can be optionally nitrosated and/or nitrosylated. The invention also provides methods for treating inflammation, pain and fever; for treating and/or improving the gastrointestinal properties of COX-2 selective inhibitors; for facilitating wound healing; for treating and/or preventing renal toxicity or other toxicities; for treating and/or preventing other disorders resulting from elevated levels of cyclooxygenase-2; and for improving the cardiovascular profile of COX-2 selective inhibitors.

专利号:US-2018334427-A1
优先权日:2015-11-18
标 题 :Process for the Synthesis of Intermediates Useful for Preparing 1,3,4-Triazine Derivatives

专利号:CN-108349868-A
优先权日:2015-11-18
标题:Process for the synthesis of intermediates useful in the preparation of 1,3,4-triazines

专利号:EP-3377470-B1
优先权日:2015-11-18
标题 :Process for the synthesis of intermediates useful for preparing 1,3,4-triazine derivatives

专利号:CN-114736181-B
优先权日:2022-04-28
标 题:Visible light-mediated synthesis of acylated benzofuran derivatives