CAS: 890707-28-5; 2-Amino-5-Chloro-N,3-Dimethylbenzamide

上下游产品

CAS号201230-82-2 carbon monoxide | CAS号146948-68-7 2-溴-4-氯-6-甲基苯胺 | CAS号74-89-5 氨基甲烷 | CAS号120374-68-7 6-chloro-8-meth... | CAS号870997-57-2 2-氨基-N,3-二甲基苯甲酰胺 | CAS号20776-67-4 2-氨基-5-氯-3-甲基苯甲酸 | CAS号79101-83-0 2-氨基-5-氯-3-甲基苯甲酸甲酯 | CAS号1391132-24-3 2-(dimethylamin... | CAS号4389-45-1 2-氨基-3-甲基苯甲酸

4-氨基-3,5-二氯苯甲酸置于氯化亚砜,硫酸,氢气,硝酸,镍体系中,用 甲醇,水,甲基环己烷,1,2-二氯乙烷 作为反应溶剂,10.0~30.0 °C,1.5 Mpa 条件下,反应 8.0H,反应生成 2-氨基-5-氯-N,3-二甲基苯甲酰胺
参考文献:一种2-氨基-5-氯-N,3-二甲基苯甲酰胺的合成方法
标题:一种2-氨基-5-氯-N,3-二甲基苯甲酰胺的合成方法
摘要:本发明涉及一种2‑氨基‑5‑氯‑n,3‑二甲基苯甲酰胺的合成方法,包括:以二氯乙烷作为反应溶剂,加入3‑甲基‑5‑氯‑苯甲酸,滴加硫酸与硝酸反应得到2‑硝基‑3‑甲基‑5‑氯苯甲酸;将2‑硝基‑3‑甲基‑5‑氯苯甲酸,氯化亚砜反应得到2‑硝基‑3‑甲基‑5‑氯苯甲酰氯;向一甲胺水溶液中滴加2‑硝基‑3‑甲基‑5‑氯苯甲酰氯溶液,反应得到2‑硝基‑5‑氯‑n,3‑二甲基苯甲酰胺;将2‑硝基‑5‑氯‑n,3‑二甲基苯甲酰胺,甲醇,雷尼镍进行硝基还原反应,获得2‑氨基‑5‑氯‑n,3‑二甲基苯甲酰胺成品.本发明工艺产品纯度高,收率高,反应条件温和,操作简单,三废大幅减少,具有环保效益,适合工业化大生产.

专利信息

专利号:WO-2025134140-A1
优先权日:2023-12-19
标题:A method for the synthesis of substituted anthranilic amide compounds, intermediates and salts thereof
发明人：MALVIYA NITIN JAIKANT; SINGH VIPENDER; SHAH JIGARKUMAR HARKISHANDAS; KALE MANOJ GANPAT; KAVITAKE SANTOSH GIRIDHAR; BORHADE AJIT SAHEBRAO; KLAUSENER ALEXANDER G M
权利人:PI INDUSTRIES LTD
摘要:The present invention discloses a method for the synthesis of compounds of formula (I) or a salt thereof, wherein, R is selected from hydrogen, halogen, cyano, C1-C12 alkyl, C1-C12 haloalkyl, C1-C12 alkoxy, C1-C12 haloalkoxy, or C3-C8 cycloalkyl; R4 is selected from hydrogen, C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl, C1-C12 haloalkyl, C2-C12 haloalkenyl, C2-C12 haloalkynyl, C1-C12 alkoxy, C1-C12 haloalkoxy, C3-C8 cycloalkyl, or C3-C8 cycloalkyl-C1-C10 alkyl; and n represents an integer selected from 0-4. The method further comprises the synthesis of an anthranilic diamide compound of formula (A).

专利号:WO-2025057193-A1
优先权日:2023-09-13
标题:A method for the synthesis of substituted anthranilic amide compounds, intermediates and salts thereof
发明人：MALVIYA NITIN JAIKANT; SINGH VIPENDER; KALE MANOJ GANPAT; SHAH JIGARKUMAR HARKISHANDAS; GAVHANE KISHOR BAPU; KAVITAKE SANTOSH GIRIDHAR; BORHADE AJIT SAHEBRAO; KLAUSENER ALEXANDER G M
权利人:PI INDUSTRIES LTD
摘要:The present invention provides a method for the synthesis of compounds of formula (I), intermediates, and salts thereof, formula (I) wherein, R, R1 and n are as described in the description. The method further comprises the synthesis of anthranilic diamide compounds of formula (E), wherein the formula (E) is described in the description.

专利号:WO-2025134143-A1
优先权日:2023-12-19
标题 :A method for the synthesis of substituted anthranilic amide compounds, intermediates and salts thereof
发明人：MALVIYA NITIN JAIKANT; SINGH VIPENDER; MAL SANJIB; YADAV SANTOSH; SHAH JIGARKUMAR HARKISHANDAS; KAVITAKE SANTOSH GIRIDHAR; BORHADE AJIT SAHEBRAO; KLAUSENER ALEXANDER G M
权利人:PI INDUSTRIES LTD
摘要:The present invention discloses a method for the synthesis of compounds of formula (I) or a salt thereof, wherein R is selected from hydrogen, halogen, cyano, C1-C12 alkyl, C1-C12 haloalkyl, C1-C12 alkoxy, C1-C12 haloalkoxy, or C3-C8 cycloalkyl; R4 is selected from hydrogen, C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl, C1-C12 haloalkyl, C2- C12 haloalkenyl, C2-C12 haloalkynyl, C1-C12 alkoxy, C1-C12 haloalkoxy, C3-C8 cycloalkyl, or C3-C8 cycloalkyl-C1-C10 alkyl; and n represents an integer selected from 0-4. The process further comprises the synthesis of an anthranilic diamide compound of formula (A).

专利号:US-2023339844-A1
优先权日:2020-09-17
标题:A process for the synthesis of anthranilic acid/amide compounds and intermediates thereof
发明人：MAHAPATRA TRIDIB; PATRA PRANAB KUMAR; KLAUSENER ALEXANDER G M; MAL SANJIB; SHARMA RAJU
权利人:PI INDUSTRIES LTD; PI INDUSTRIES LTD
摘要:The present invention disclosed a process for the synthesis of compound of formula (Z) or a salt thereof, n n n n n n n n n n wherein, R, R 1 , R 2 , R 3 and R 10 are as defined in the detailed description. The process further comprises the synthesis of an anthranilic diamide compound of formula (I).

专利号:WO-2021033172-A1
优先权日:2019-08-20
标题:Process for the preparation of chlorantraniliprole
发明人：V ASHWIN; PRADHAN ASHOK KUMAR; PALIMKAR SANJAY SAMBHAJIRAO; MANE AVINASH SHESHRAO; KUNHIMON SYAM KUMAR UNNIARAN
权利人:EUROFINS ADVINUS LTD
摘要:The present invention relates to two novel, efficient and one-pot methods for synthesizing chlorantraniliprole. In the first scheme, Chlorantraniliprole is prepared by a novel telescopic process starting from 3-Bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid a key raw material-A (Key RM-A). In the second scheme, starting from Key RM-A, the process steps use of a novel variant of anthranilic acid (Methyl 2-amino-5-chloro-3-methylbenzoate), to get Chlorantraniliprole. Furthermore, the present invention also relates to the synthesis of key starting material for the synthesizing chlorantraniliprole in-situ. All the in-situ steps of the disclosed synthesis methods obtain good yield, without using any expensive reagent or base or harsh reaction conditions, which makes the process simple, environment friendly and more cost effective. With this process the production cost of chlorantraniliprole and its intermediates is substantially reduced; fewer by-products are formed during its synthesis and since it's a one-pot reaction, isolation and purification are easy to achieve.

专利号:US-12304893-B2
优先权日:2019-11-01
标 题 :Process for synthesis of 2-amino-5-chloro-N-,3-dimethylbenzamide
发明人：CHEN LIANG; FAN YEFENG; MAO JIANHUA; XU ZHIJIAN
权利人:FMC CORP; FMC AGRO SINGAPORE PTE LTD; FMC IP TECH GMBH
摘要:Described herein are novel methods of synthesizing 2-amino-5-chloro-N,3-dimethylbenzamide. Compounds prepared by the methods disclosed herein are useful for preparation of certain anthranilamide compounds that are of interest as insecticides, such as, for example, the insecticides chlorantraniliprole and cyantraniliprole.