CAS: 1010-26-0; 1,1-Cyclohexanediacetic Anhydride

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CAS号4355-11-7 1,1-环己基二乙酸 | CAS号4355-15-1 3-Azaspiro[5.5]... | CAS号99189-60-3 1,1-环已基二乙酸单酰胺(CAM) | CAS号60142-96-3 加巴喷丁 | CAS号113009-25-9 2-[1-(2-oxo-2-p... | CAS号60142-94-1 1,1-环己基二乙酸单甲酯 | CAS号6051-08-7 3-oxaspiro[5.5]...

2,4-二氧代-3-氮杂螺[5.5]十一烷-1,5-二甲腈置于盐酸,水,乙酸酐,溶剂黄146体系中,化学反应 88.0H,反应生成1,1-环己基二乙酸酐
参考文献:Antiarthritic And Supressor Cell Inducing Activity Of Azaspiranes: Structure-Function Relationships Of A Novel Class Of Immunomodulatory Agents
标题:Antiarthritic And Supressor Cell Inducing Activity Of Azaspiranes: Structure-Function Relationships Of A Novel Class Of Immunomodulatory Agents
摘要:Spirogermanium (1; 8,8-Diethyl-N,N-Dimethyl-2-Aza-8-Germaspiro[4.5]Decane-2-Propanamine Dihydrochloride) Is A Potent Cytotoxic Agent In Vitro Which Has Demonstrated Limited Activity In Experimental Animal Tumor Models. Subsequently,It Has Been Reported That Spirogermanium Has Antiarthritic And Suppressor Cell-Inducing Activity. We Have Synthesized A Series Of Substituted 8-Hetero-2-Azaspiro[4.5]Decane And 9-Hetero-3-Azaspiro[5.5]Undecane Analogues Of Spirogermanium To Identify The Heteroatom Requirements For In Vivo Antiarthritic And Suppressor Cell-Inducing Activity. This Structure-Activity Relationship Study Has Identified That Appropriately Substituted Silicon And Carbon Analogues Of Spirogermanium Retain Both Antiarthritic And Immunosuppressive Activity,With The 8,8-Dipropyl (Carbon) Analogue Being Among The Most Active. Following The Identification Of N,N-Dimethyl-8,8-Dipropyl-2-Azaspiro[4.5]Decane-2-Propanamine++ + Dihydrochloride (9) As A More Active Analogue Than Spirogermanium,A Series Of 8,8-Dipropyl Analogues With Various Amine Substituents Were Synthesized. A Number Of These Analogues Had Activity Similar To That Of 9. A Correlation Between Activity In The Adjuvant Arthritic Rat And The Ability To Induce Suppressor Cells (R = 0.894,P Less Than 0.001) Suggests An Association Between The Two Pharmacologic Effects. While The Precise Biochemical Mechanism(S) For The Pharmacological Activity Is Unclear,These Data Suggest That Compounds Within This Series,E.G.,N,N-Dimethyl-8,8-Dipropyl-2-Azaspiro[4.5]Decane-2-Propanamine++ + Dihydrochloride,May Provide Effective Therapy In Diseases Of Autoimmune Origin And/or The Prevention Of Rejection In Tissue Transplantation.
Doi:10.1021/jm00173A010

专利信息

专利号:US-2008103334-A1
优先权日:2006-10-26
标 题:Process For Synthesis Of Gabapentin
发明人：KUMAR ASHOK; SOUDAGAR SATISH RAJANIKANT; NIJASURE AVINASH MANOHAR; PANDA NALINAKSHYA BALARAM; GAUTAM PRASHANT; THAKUR GAJENDRASINGH RAMSINGH
权利人:IPCA LAB LTD
摘要:A process for preparation of gabapentin comprising a step of obtaining 1,1-cyclohexane diacetic acid monoamide from 1,1-cyclohexane diacetic acid anhydride, wherein said reaction is characterized by the use of ammonia precursor or pre-generated ammonia-isopropanol solution. The invention further discloses preparation of gabapentin and isolation of gabapentin in polymorphic Form II with high yield and purity.

专利号:US-7759517-B2
优先权日:2004-06-24
标 题:Process for the preparation of gabapentin
发明人：VILLA MARCO; PAIOCCHI MAURIZIO; ARRIGHI KATIUSCIA; CORCELLA FRANCESCO; CANNATA VINCENZO; SORIATO GIORGIO; VERZINI MASSIMO
权利人:ZACH SYSTEM SPA
摘要:The present invention relates to a process for the preparation of gabapentin and, more in particular, to a method of synthesis of 1,1-cyclohexane acetic acid monoamide, an intermediate used in the preparation of gabapentin, comprising the basic hydrolysis reaction of α, -diaminocarbonyl-β,β-pentamethylene glutarimide.

专利号:US-8143437-B2
优先权日:2002-02-19
标题:Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
发明人：GALLOP MARK A; XIANG JIA-NING; YAO FENMEI; BHAT LAXMINARAYAN; ZHOU CINDY X
权利人:GALLOP MARK A; XIANG JIA-NING; YAO FENMEI; BHAT LAXMINARAYAN; ZHOU CINDY X; XENOPORT INC
摘要:The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require the use of activated intermediates and/or toxic compounds and is readily amendable to scale-up. The current invention also provides 1-acyl-alkyl derivatives of known drug components and methods for synthesizing these 1-acyl-alkyl derivatives.

专利号:US-2005239725-A1
优先权日:2002-02-19
标题:Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof

专利号:US-4810778-A
优先权日:1986-01-16
标 题 :Intermediates for preparing 1,6-dicarba-vasopressin compounds
发明人：CALLAHAN JAMES F; HUFFMAN WILLIAM F; NEWLANDER KENNETH A; YIM NELSON C F
权利人:SMITHKLINE BECKMAN CORP
摘要:New compounds which have potent V2-vasopressin antagonistic activity are prepared by a 1,6-cyclization using peptide bond formation. The structures of the compounds are characterized by the Pas1,6 or Tas1,6 cyclized unit. Also a chiral synthesis of the optically pure Pas intermediates is described.

专利号:US-4760052-A
优先权日:1986-01-16
标 题 :1,6-dicarba-vasopressin compounds
发明人：CALLAHAN JAMES F; HUFFMAN WILLIAM F; NEWLANDER KENNETH A; YIM NELSON C F
权利人:SMITHKLINE BECKMAN CORP
摘要:New compounds which have potent V2-vasopressin antagonistic activity are prepared by a 1,6-cyclization using peptide bond formation. The structures of the compounds are characterized by a Pas1,6 or Tas1,6 cyclized unit. Also a chiral synthesis of the optically pure Pas intermediates is described.