CAS: 10297-05-9; 1-Chloro-4-Iodobutane

该化合物是一种有机化合物,被归类为卤化甘油, 含有四碳丁烷链, 最初碳为氯原子, 第四碳为碘原子, 典型的杂质无色可粉黄, 与其他卤化甘蔗相比, 密度中等, 沸点相对较低. 它在有机溶剂中溶解, 但由于其盐酸碳氢化合物链, 其溶解性有限. 氯和碘原子的存在, 使它在有机合成中成为多功能的中间体, 特别是在核脑细胞替代反应中. 它的活性受到卤素电子密度的影响, 碘比氯化要好. 与许多卤化甘蔗相比, 1-氯-4-碘丁烷应该受到谨慎处理, 因为它具有潜在的毒性和与卤化化合物相关的环境关切. 建议在与该物质打交道时采取适当的安全措施, 包括使用个人防护设备.

结构式图片

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CAS号110-56-5 1,4-二氯丁烷 | CAS号41049-30-3 4-Iodobutyl Tet... | CAS号111-13-7 2-辛酮 | CAS号928-51-8 4-氯-1-丁醇 | CAS号26910-61-2 4-chlorobutyl m... | CAS号4096-21-3 1-苯基吡咯烷 | CAS号92-52-4 联苯 | CAS号4830-93-7 1-氯-4-苯基丁烷 | CAS号942-93-8 5-chloro-1-phen... | CAS号1821-12-1 4-苯基丁酸 | CAS号1002-50-2 7-chlorohept-2-... | CAS号10297-06-0 6-氯-1-己炔 | CAS号35087-20-8 1-Chloro-5-dodecyne | CAS号14860-82-3 4-丙氧基氯丁烷

合成工艺路线路线简述

    4-Chlorobutyl Methanesulfonate置于丙酮,Sodium Iodide体系中,化学反应生成1-氯-4-碘丁烷
    参考文献:烷基和取代烷基甲磺酸盐的制备和一些裂解反应:氟化物,碘化物和硫氰酸盐的合成
    标题:烷基和取代烷基甲磺酸盐的制备和一些裂解反应:氟化物,碘化物和硫氰酸盐的合成
    摘要:合成了具有代表性的甲磺酸酯,并裂解形成相应的氟化物,碘化物和硫氰酸酯.从这项工作中开发了一种方便的实验室程序,用于将醇转化为氟化物.
    Doi:10.1139/v56-099

    专利信息


    专利号:US-4026911-A
    优先权日:1976-02-23
    标 题:Process for the preparation of ketoalkynoic acids and use of the process in an improved synthesis of 2-(substituted)-cyclo-pentane-1,3,4-triones
    发明人:REVERMAN LAWRENCE FRANCIS
    权利人:MILES LAB
    摘要:Reaction of a 2-methyl-2-(alkenyl)-1,3-dioxolane with an α,ω-dihalogenoalkane to obtain a 2-methyl-2-(ω-chloroalkynyl)-dioxolane, conversion of the latter to a corresponding nitrile, and hydrolysis of the nitrile to form a ketoalkynoic acid is a novel process for preparing the acid. n Use of the process in the synthesis of 2-(substituted)-cyclopentane-1,3,4-triones improves that synthesis.

    专利号:WO-2024182268-A1
    优先权日:2023-02-27
    标 题 :Liquid phase peptide support synthesis of peptides and peptidomimetics
    发明人:HAN AMY
    权利人:REGENERON PHARMA
    摘要:The present invention provides compounds useful as support for liquid phase organic synthesis e.g., liquid phase organic synthesis of peptides and peptidomimetics. In one aspect, the present invention provides a compound having a structure of Formula (I) where R1, R2, R3, m, and n are as described herein and methods of making and using same.

    专利号:US-5948789-A
    优先权日:1994-07-15
    标题:Process for synthesis of substituted sulphoxides
    发明人:LARSSON MAGNUS ERIK; STENHEDE URBAN JAN; SOERENSEN HENRIK; VON UNGE SVERKER PER OSKAR; COTTON HANNA KRISTINA
    权利人:ASTRA AB
    摘要:PCT No. PCT/SE95/00818 Sec. 371 Date Jul. 14, 1995 Sec. 102(e) Date Jul. 14, 1995 PCT Filed Jul. 3, 1995 PCT Pub. No. WO96/02535 PCT Pub. Date Feb. 1, 1996A novel process for enantioselective synthesis of single enantiomers of omeprazole or its alkaline salts, of other optically pure substituted 2-(2-pyridinylmethyl-sulphinyl) -1H-benzimidazoles as well as of other structurally related sulphoxides or their alkaline salts. The claimed process is an asymmetric oxidation of a pro-chiral sulphide to the single enantiomers or an enantiomerically enriched form of the corresponding sulphoxide. The application also claims the enantiomeric sulphoxide products produced by the process and their use in medicine.

    专利号:US-9371334-B2
    优先权日:2010-09-22
    标题:Synthesis of substituted salicylaldehyde derivatives
    发明人:FARMER JAY J; JOB GABRIEL E
    权利人:NOVOMER INC
    摘要:Among other things, the present invention encompasses methods of synthesizing salicylaldehyde derivatives comprising the steps of: a) providing salicylaldehyde or a derivative thereof, b) forming an anhydro dimer of the provided salicylaldehyde compound, c) performing one or more chemical transformations on the anhydro dimer and d) hydrolyzing the anhydro dimer to provide a salicylaldehyde derivative different from that provided in step (a).

    专利号:US-7288655-B2
    优先权日:2003-03-07
    标 题 :α v integrin receptor antagonists
    发明人:BISHOP BRIAN CHRISTOPHER; BRANDS KAREL MARIE JOSEPH; COTTRELL IAN FRANK; COWDEN CAMERON JOHN; DAVIES ANTONY JOHN; KEEN STEPHEN PHILIP; LIEBERMAN DAVID ROSS; STEWART GAVIN WILLIAM
    权利人:MERCK SHARP & DOHME
    摘要:The present invention relates to the synthesis of intermediates for the preparation of compounds of formula (A): wherein n is 2 or 3 and various salt forms of these compounds. The compounds of formula (A) are useful as ανβ3 receptor antagonists

    专利号:US-8067460-B2
    优先权日:2004-10-04
    标 题 :5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated Kv1.3 potassium channel
    发明人:WULFF HEIKE; SANKARANARAYANAN ANANTHAKRISHNAN; HAENSEL WOLFRAM; SCHMITZ ALEXANDER; SCHMIDT-LASSEN KRISTINA
    权利人:WULFF HEIKE; SANKARANARAYANAN ANANTHAKRISHNAN; HAENSEL WOLFRAM; SCHMITZ ALEXANDER; SCHMIDT-LASSEN KRISTINA; UNIV CALIFONIA
    摘要:Compositions of matter comprising 5-phenoxyalkoxypsoralen compounds and their method of synthesis and use. The compounds are useable to treat diseases or disorders in human or animal subjects, including autoimmune diseases. The compounds inhibit potassium channels, including the Kv1.3 channel and at least some of the therapeutic effects of such compounds may be due at least in part to potassium channel inhibition. In some embodiments, the compounds are more selective for certain potassium channels (e.g., Kv1.3 channels) than other potassium channels (e.g., Kv1.5 channels).
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    主要参考文献

    参考标题:The Asymmetric Synthesis Of Amines Via Nickel-Catalyzed Enantioconvergent Substitution Reactions
    作者:Ze-Peng Yang,Dylan J. Freas,Gregory C. Fu |发布日期:2021.2.24
    摘要:Dialkyl Carbinamines Do Not Provide General Access To Amines Wherein The Two Alkyl Groups Are Of Similar Size (E.G., Ch2R Versus Ch2R1). Herein, We Report Two Mild Methods For The Catalytic Enantioconvergent Synthesis Of Protected Dialkyl Carbinamines, Both Of Which Use A Chiral Nickel Catalyst To Couple An Alkylzinc Reagent (1.1-1.2 Equiv) With A Racemic Partner, Specifically, An α-Phthalimido Alkyl Chloride

    合成参考文献


    摘要:Koutentis, P. A.; Ioannidou, H. A., Science of Synthesis Knowledge Updates, (2010) 1, 370.
    摘要:Wolf, C., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 875.
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