CAS: 13361-32-5; Allyl 2-Cyanoacetate

相似化合物

106-71-8 14447-15-5 7085-85-0

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CAS号372-09-8 氰基乙酸 | CAS号107-18-6 烯丙醇 | CAS号105-56-6 氰乙酸乙酯 | CAS号592-51-8 4-戊烯腈 | CAS号75265-83-7 2-allylpent-4-e... | CAS号102804-61-5 prop-2-enyl 2-c... | CAS号102804-59-1 prop-2-enyl 2-b... | CAS号1142329-69-8 allyl tricyanoe... | CAS号109-77-3 丙二腈 | CAS号7324-02-9 ALLYL-2-CYANOAC...

氰乙酸,烯丙醇置于硫酸体系中,用 苯 用作溶剂,化学反应生成氰乙酸烯丙酯
参考文献:质谱研究-Xvii:某些含有不饱和键的酯的重排过程-从酯中消除co 2
标题:质谱研究-Xvii:某些含有不饱和键的酯的重排过程-从酯中消除co 2
摘要:已经测量了各种丙酸酯,乙炔二羧酸酯,马来酸酯,富马酸酯和氰基乙酸酯的质谱.在这些酯中,通过消除二氧化碳(有或没有其他基团的相关损失)形成离子是很常见的.相对于元素映射技术而言,这种断裂过程的普遍性很重要,它可能与双键或三键(在酯官能团附近)的存在有关,双键或三键的存在可能会由于去除电子而被电离.并因此提供一个基团(烷基,烯基等)可迁移至的缺电子位点.
Doi:10.1016/s0040-4020(01)83315-9

专利信息

专利号:WO-2012059797-A1
优先权日:2010-11-04
标题 :Process for synthesis of (s) - pregabalin
发明人：ROY BHAIRAB NATH; SINGH GIRIJ PAL; LATHI PIYUSH SURESH; AGRAWAL MANOJ KUNJABIHARI; MITRA RANGAN; RUPNAWAR MANOJ DATTATRAYA
权利人:LUPIN LTD; ROY BHAIRAB NATH; SINGH GIRIJ PAL; LATHI PIYUSH SURESH; AGRAWAL MANOJ KUNJABIHARI; MITRA RANGAN; RUPNAWAR MANOJ DATTATRAYA
摘要:Improved process for the synthesis of (S)-pregabalin having more than 99% ee through (S) 3-cyano-5-methyl-hexanoic acid has been developed. In addition to above, a novel process for resolution of ( RS ) - 3-cyano-5-methyl-hexanoic acid through diastereomeric salt formation with cinchonidine to obtain ( S ) - 3-cyano-5-methyl-hexanoic acid in high yield and high optical purity has been developed and furthermore process for recovery/ reuse of cinchonidine is also developed to improve the overall process efficiency.

专利号:US-2012149895-A1
优先权日:2009-04-01
标题 :Process for dimethylation of active methylene groups
发明人：JENKO BRANKO; COPAR ANTON
权利人:JENKO BRANKO; COPAR ANTON; LEK PHARMACEUTICALS
摘要:The present invention discloses a process for dimethylation of active methylene groups. Specifically, the invention discloses a process for preparing 3-amino-2,2-dimethylpropanamide. Compounds produced by the present dimethylation process such as 3-amino-2,2-dimethylpropanamide can be used as intermediates in the route of synthesis of therapeutic, prophylactic or diagnostic agent, for example aliskiren or cryptophycin. Particularly, the invention relates to embodiments further extending to processes for preparing pharmaceutical dosage form comprising said therapeutic, prophylactic or diagnostic agents. More specifically, the invention relates to the use of compounds produced by the present dimethylation process for the manufacture of therapeutic, prophylactic or diagnostic agents or for the manufacture of pharmaceutical dosage forms comprising said therapeutic, prophylactic or diagnostic agents. The processes according to the present invention can be beneficially applied for the synthesis of various active pharmaceutical ingredients, such as aliskiren or crypthophycin.

专利号:WO-2013121018-A1
优先权日:2012-02-17
标题 :Synthesis of cyanocarboxylic acid alkyl esters
发明人：FRANZKE CONSTANZE; OTT LOTHAR; GRUETZNER THOMAS; LITZMANN OLIVER; REPKE JENS-UWE; HAMMANN MARKUS; LORENZ HILKE-MARIE; MEEMKEN FABIAN CARL INGOLD
权利人:LONZA AG
摘要:Provided is a process for obtaining a compound of formula (I): N≡C-CH 2 -A-C(O)-OR, wherein Hal is halogen selected from F, Cl, Br or I, A denotes a bond or a divalent spacer selected from alkylene and arylene groups, and R is a C 1-4 alkyl group, by reacting a compound of formula (II): Hal-CH 2 -A-C(O)-OR, wherein Hal is a halogen atom selected from F, Cl, Br and I, and wherein A and R are as defined above, with hydrogen cyanide in the presence of a first base, wherein the molar ratio between hydrogen cyanide and said first base is from 1:0.3 to 1:0.95 and the molar ratio between hydrogen cyanide to the compound of formula (II) is at least 1:1.

专利号:EP-1264823-A1
优先权日:2001-06-08
标 题:Process for the preparation of 2,3-dicyanopropionates
发明人：SCHUELE GUNTER
权利人:NOVARTIS AG
摘要:The invention relates to a process for the preparation of a compoundnof formulan nwherein R represents branched or unbranchedn(C 1 -C 6 -alkoxy) 1-10 -C 2 -C 6 -alkyl,nC 3 -C 8 -cycloalkyl, allyl, propargyl, phenyl ornphenyl-C 1 -C 6 -alkyl; or a salt thereof;nwhich comprises the reaction of a cyanoacetate of formulan nwherein R is defined as in formula I, with formaldehyde or a sourcenthereof in the presence of a cyanide salt. The compounds of formula Inare useful as intermediates in the synthesis of pesticidally activencompounds.

专利号:US-8981115-B2
优先权日:2008-09-30
标 题 :Process for the synthesis of halogenated cyclic compounds
发明人：BRAUN MAX
权利人:SOLVAY
摘要:A process for the manufacture of a cyclic compound of formula (I) n n n n n n n n n n which comprises (a) adding an acid halide of formula R 1 —C (O)—X, to a vinyl ether of formula (II): CH 2 â•?CH—OR 2 , to produce an addition product, and (b) reacting the addition product with a compound of formula (III): Y-A-Z; wherein R 1 is a halogenated alkyl group; wherein X is fluorine, chlorine, or bromine; wherein R 2 is an alkyl group, an aralkyl group, or an aryl group; wherein Z and Y designate independently carbon or a heteroatom; and wherein A is a linking group between Z and Y comprising 0, 1, 2 or 3 atoms in the cycle.

专利号:US-6660871-B2
优先权日:2001-02-01
标 题 :Synthesis of 4H-chromene derivatives
发明人：HUANG ZIWEI
权利人:THOMAS JEFFERSON UNVERSITY
摘要:Substituted 4H-chromene derivatives are a new class of compounds that bind to Bcl-2 protein and induce apoptosis in tumor cells. The present invention is directed to an efficient synthetic method for the preparation of these compounds from salicylaldehyde derivatives and alkyl cyanoacetates under solid phase.