CAS: 140860-51-1; 2-Bromo-4-Methoxybenzonitrile

相似化合物

43192-31-0 74317-85-4 36942-56-0

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CAS号874-90-8 4-甲氧基苯甲腈 | CAS号7507-86-0 2-溴-5-甲氧基苯甲醛 | CAS号36282-26-5 2-溴-4-氟苯甲腈 | CAS号124-41-4 甲醇钠 | CAS号186581-53-3 重氮甲烷 | CAS号82380-17-4 2-溴-4-羟基苯甲腈 | CAS号74317-85-4 2-溴-4-甲氧基-苯甲酸

4-甲氧基苯甲腈置于n-溴代丁二酰亚胺(Nbs),Palladium Diacetate,对甲苯磺酸体系中,用 1,2-二氯乙烷 用作溶剂,化学反应 12.0H,以79%的收率获得2-溴-4-甲氧基苯甲腈
参考文献:Palladium-Catalyzed Highly Selective Ortho-Halogenation (I,Br,Cl) Of Arylnitriles Via Sp2 C-h Bond Activation Using Cyano As Directing Group
标题:Palladium-Catalyzed Highly Selective Ortho-Halogenation (I,Br,Cl) Of Arylnitriles Via Sp2 C-h Bond Activation Using Cyano As Directing Group
摘要:A Palladium-Catalyzed Ortho-Halogenation (I,Br,Cl) Of Arylnitrile Is Described. The Optimal Reaction Conditions Were Identified After Examining Various Factors Such As Catalyst,Additive,Solvent,And Reaction Temperature. Using Cyano As The Directing Group,The Halogenation Reaction Gave Good To Excellent Yields. The Method Is Compatible To The Arylnitriles With Either Electron-Withdrawing Or Electron-Donating Groups. The Reaction Is Available To The Substrate In At Least Gram Scale. The Present Method Was Successfully Applied To The Synthesis Of The Precursors Of Paucifloral F And Isopaucifloral F.
Doi:10.1021/jo302765G