CAS: 22560-50-5; Sodium (Dichloro(Phosphono)Methyl)Phosphonate

该化合物是一种二磷酸化合物,广泛用于生化和制药研究,是骨质激素中转骨吸附的强大抑制剂,对骨质疏松症和骨代谢紊乱的研究很有价值;二钠盐形式提高了水溶液的溶性,促进了其在体外和体内应用中的溶解性,高纯度和稳定性确保了实验环境中的可靠性能;此外,二钠硫酸盐由于有选择性的细胞毒性而被用于对脑细胞的大型耗竭研究中,其特征是其连续的成批至批再生,符合严格的研究标准.

英文名称Sodium (Dichloro(Phosphono)Methyl)Phosphonate
中文名称氯屈膦酸二钠
IUPAC名称disodium;[dichloro-[hydroxy(oxido)phosphoryl]methyl]-hydroxyphosphinate
其它别名Clodronic acid disodium salt
CAS编号22560-50-5
MFCD编号:MFCD01632786
EINECS号:245-078-9
FDA UNII编号:Y05R4GCQ1H
分子式:CH2Cl2Na2O6P2
分子量:288.86
产品CID: 1163664
产品分类有机原料→生命科学→生化试剂→螯合剂

相似结构搜索
InChIKey: HJKBJIYDJLVSAO-UHFFFAOYSA-L
InChI=1S/CH4Cl2O6P2.2Na/c2-1(3,10(4,5)6)11(7,8)9;;/h(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2…
计算化学: 氢键受体数4.0氢键供体数2.0可旋转键数4.0

相似化合物

87591-00-2

物理性质

熔点>330°C
沸点474.7 °C at 760mmHg
闪点240.9 °C
密度2.306g/cm3
PSA:93.06
LogP:0.6463
蒸汽压2.55E-10mmHg at 25°C
溶解性Freely Soluble In Water, Practically Insoluble In Ethanol (96 Per Cent), Slightly Soluble In Methanol.
外观形态白色至类白色固体
储存条件室温

MSDS等安全信息

GHS象形图
GHS符号GHS08 & GHS09;
注释: Health hazard & Environment
危险类别特定目标器官毒性-重复接触类别2
水生慢性毒性类别2
急性毒性类别4(经口)
水生慢性毒性类别3
警示词Warning(警告)
危险描述H373 |长期或反复接触可能损害器官.
H411 |对水生生物有毒并具有长期持续影响.
H302 |吞咽有害.
H412 |对水生生物有害并具有长期持续影响.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
UN编号NONH for all modes of transport
危险品标志Xi
安全声明The bisphosphonate group binds strongly to the bone mineral, hydroxyapatite. This explains the specific pharmacological action of these compounds on mineralized tissues, especially bone. The exact mechanism of action of clodronate is not known, however it is known that it does not inhibit protein isoprenylation but can be metabolized intracellularly to a β-γ-methylene (AppCp-type) analog of ATP (AppCCl2p), which is cytotoxic to macrophages in vitro. Inhibition of the ADP/ATP translocase by the metabolite AppCCl2p is a likely route by which clodronate causes osteoclast apoptosis and inhibits bone resorption. Recently, the slime mold <i>Dictyostelium discoideum</i> was shown to take up bisphosphonates by pinocytosis. In these cells, clodronate, but not other pharmacologically active bisphosphonates, was incorporated into adenine nucleotides, which could potentially explain why this bisphosphonate sometimes seems to act differently than the other bisphosphonates. Clodronate, like all biphosphonates, also binds protein-tyrosine-phosphatase.
WGK Germany3

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

合成工艺路线路线简述

海关参考信息

2903120001-二氯甲烷
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专利信息

专利号:US-2017283878-A1
优先权日:2015-12-11
标题:Modulation of globoseries glycosphingolipid synthesis and cancer biomarkers
发明人：WONG CHI-HUEY; WU CHUNG-YI; CHEUNG SARAH K C; CHUANG PO-KAI; HSU TSUI-LING
权利人:ACADEMIA SINICA
摘要:The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid SSEA-3/SSEA-4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta-4GalNAcT-I; or beta-3GalT-V enzymes in the globoseries synthetic pathway. Additionally, the present disclosure is also directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA-3/SSEA-4/GLOBO H associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globoseries glycosphingolipid synthesis. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions. Furthermore, the instant disclosure also relates to cancer stem cell biomarkers for diagnostic and therapeutic uses.