CAS: 32677-01-3; H-Glu(Otbu)-Otbu.Hcl

相似化合物

172793-31-6 138-15-8 144313-55-3

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Z-L-Glu-(O-T-Bu)-O-T-Bu置于palladium On Activated Charcoal 氢气体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应生成 L-谷氨酸二叔丁酯盐酸盐
参考文献:人β促脂解素的片段的合成,β ħ-Lph.第六部分 Des-1-酪氨酸-α-内啡肽和短肽的合成†
标题:人β促脂解素的片段的合成,β ħ-Lph.第六部分 Des-1-酪氨酸-α-内啡肽和短肽的合成†
摘要:描述了des-1-酪氨酸-α-内啡肽和这种精神刺激型神经肽的十四个片段的合成.在这些合成中,使用了经典的片段缩合方法.
DOI:10.1002/recl.19831021101

专利信息

专利号:WO-2025088147-A1
优先权日:2023-10-27
标题 :Theranostic psma-targeting ligands for the diagnosis and treatment of psma-expressing cancers and their solid phase synthesis
发明人：Schäfer Martin; BAUDER-WUEST ULRIKE; ROSCHER MAREIKE; REMDE YVONNE; BENEÅ OVÃ?-SCHÄFER MARTINA; BARINKA CYRIL; KUTILOVÃ? ZSÓFIA; MOTLOVÃ? LUCIA
权利人:DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OEFFENTLICHEN RECHTS
摘要:The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers, imaging agents and radiopharmaceuticals for the treatment of various disease states of PSMA-expressing cancers, especially prostate cancer, and metastases thereof. Further the present invention provides synthetic procedures for the synthesis of such PSMA-targeting ligands.

专利号:US-2004266796-A1
优先权日:2003-06-25
标 题:Convergent processes for the synthesis of a GARFT inhibitor containing a methyl substituted thiophene core and intermediates therefor
发明人：DOVALSANTOS ELENA; FLAHIVE ERIK JON; HALDEN BRIAN JOHN; MITCHELL MARK BRYAN; NOTZ WOLFGANG REINHARD LUDWIG; O'NEILL-SLAWECKI STACY ANN; TIAN QINGPING
权利人:AGOURON PHARMA
摘要:The invention relates to processes for the preparation of a GARFT inhibitor containing a methyl substituted thiophene core having the following structure: n n n wherein each of R 1 and R 2 are independently a hydrogen atom or a moiety that together with the attached CO 2 forms a readily hydrolyzable ester group; from an intermediate of the formula n n n wherein R 3 is a moiety that together with the attached CO 2 forms a readily hydrolyzable ester group; n Pg 1 is an amino protecting group; n R 4 is H; n or Pg 1 can optionally be taken together with R 4 and the nitrogen to which Pg 1 and R 4 are attached to form (i) an imine; or (ii) a fused or bridged bicyclic ring or a spirocyclic ring, wherein said ring is saturated and contains from 5 to 12 carbon atoms in which up to 2 carbon atoms are optionally replaced with a hetero moiety selected from O, S(O) j wherein j is an integer from 0 to 2, and —NR 8 —, provided that two O atoms, two S(O) j moieties, or an O atom and a S(O) j moiety are not attached directly to each other; n R 5 is selected from the group consisting of —C≡C— and —CHâ•?CH—; and n R 8 is independently H or C 1 -C 6 alkyl; n to form the compound of the formula (I) that is optically pure; and to processesfor preparing intermediates thereof.

专利号:US-6916949-B2
优先权日:2001-01-29
标 题 :Methods of chemical systhesis of phenolic nitrogen mustard prodrugs
发明人：SPRINGER CAROLINE JOY; NICULESCU-DUVAZ DAN
权利人:CANCER REC TECH LTD
摘要:This invention pertains to novel methods for the synthesis of certain nitrogen mustard prodrugs, such as N-{4-[N,N-bis(2-haloethylamino)-phenoxycarbonyl}-L-glutamic acid: wherein: X² is a halo group, and is -F, -Cl, -Br, or -I; n is an integer from 0 to 4; and, each R^A is an aryl substituent. The methods comprise, at least, the steps of: glutamate conjugation (GC); silyloxy deprotection (SD); and, sulfonic esterification (SU). Certain preferred methods comprise the steps of: amine substitution (AS); silyloxy protection (SP); phenolic deprotection (PD); activation (AC); glutamate conjugation (GC); silyloxy deprotection (SD); sulfonic estenfication (SU); halogenation (HL); glutamate deprotection (GD); and glutamic acid protection (GP).

专利号:WO-2024169886-A1
优先权日:2023-02-16
标 题 :Psma targeted radioactive drug for integrated diagnosis and treatment, and synthesis and use thereof
发明人：YAN CHENGLONG; YU SHANYOU; FANG PENG; ENG WAI-SI; YANG SI
权利人:NORROY BIOSCIENCE CO LTD
摘要:Provided are a PSMA targeted radioactive drug for integrated diagnosis and treatment, and the synthesis and use thereof. Specifically, the present invention relates to a compound or a pharmaceutically acceptable salt, ester or solvate thereof. The structure of the compound is as represented by formula (I). The compound can be used for diagnosing and/or treating one or more tumors, cancers or cells expressing PSMA.

专利号:WO-02060862-A1
优先权日:2001-01-29
标题:Methods of chemical synthesis of phenolic nitrogen mustard prodrugs

专利号:EP-1355876-B1
优先权日:2001-01-29
标题:Methods of chemical synthesis of phenolic nitrogen mustard prodrugs