三缩四乙二醇置于sodium Ethanolate 镍体系中,用 甲醇,乙醚,二氯甲烷,苯 用作溶剂,化学反应 1.0H,反应生成15-冠醚-5 参考文献:Preparation Of Macrocyclic Polyether-Thiono Diester And-Thiono Tetraester Ligands Containing Either The Pyridine Subcyclic Unit Or The Oxalyl Moiety,Their Complexes,And Their Reductive Desulfurization To Crown Ethers 标题:Preparation Of Macrocyclic Polyether-Thiono Diester And-Thiono Tetraester Ligands Containing Either The Pyridine Subcyclic Unit Or The Oxalyl Moiety,Their Complexes,And Their Reductive Desulfurization To Crown Ethers 摘要: Doi:10.1021/jo00164A001
专利号:US-7241399-B2 优先权日:2000-09-08 标题 :Synthesis of nanoparticles 发明人:HAUBOLD STEPHAN; HAASE MARKUS; RIWOTZKI KARSTEN; WELLER HORST; MEYSSAMY HEIKE; IBARRA FERNANDO 权利人:CT ANGEWANDTE NANOTECH CAN 摘要:Methods for the preparation of inorganic nanoparticles capable of fluorescence, wherein the nanoparticles consist of a host material that comprises at least one dopant. The synthesis of the invention in organic solvents allows to gain a considerably higher yield compared to the prior art synthesis in water. All kinds of objects can advantageously be marked and reliably authenticated by using an automated method on the basis of a characteristic emission. Further, the size distribution of the prepared nanoparticles is nartower which renders a subsequent size-selected separation process superfluous.
专利号:US-2008103312-A1 优先权日:2006-08-29 标 题:Processes for the synthesis of 5-phenyl-1-trityl-1H-tetrazole 发明人:KANSAL VINOD K; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; LUNAGARIYA VIJAYKUMAR D 权利人:KANSAL VINOD K; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; LUNAGARIYA VIJAYKUMAR D 摘要:Provided are processes for the synthesis of 5-phenyl-1-trityl-1H-tetrazole, an intermediate useful in the synthesis of irbesartan.
专利号:US-4751312-A 优先权日:1984-07-20 标 题:Process and intermediates for the synthesis of diastereomeric compounds 发明人:GASTEIGER JOHANN; KAUFMANN KARLHEINZ; MENGEL RUDOLF 权利人:BAYER AG 摘要:A new process for the controlled synthesis of the two diasteromeric forms of triazolyl-O,N-acetals of the formula (I) in which R represents optionally substituted phenyl, optionally substituted phenoxy, optionally substituted alkoxy, optionally substituted alkoxy, optionally substituted alkylthio, alkylcarbonyl, nitro or halogen and n represents an integer from 0 to 5, with the proviso that R can represent identical or different radicals, if n represents an integer from 2 to 5. New trans-substituted oxiranes and their use as intermediates for the synthesis of compounds of the formula (I).
专利号:US-2025179020-A1 优先权日:2023-12-05 标 题:Synthesis of bis-oxime heterocycles 发明人:BLUMBERG SHAWN T; DORSEY CHRISTOPHER L 权利人:SOUTHWEST RES INST 摘要:A synthesis of bis-oxime heterocycles via reaction of 2,4-dimethyl pyridine or 2,4-dimethylpyrimidine in the presence of a phase transfer catalyst. Such bis-oxime heterocycles provide a more direct route to the synthesis of bis-quaternary pyridinium compounds and their analogs as nerve agent antidotes.
专利号:US-12281135-B2 优先权日:2019-07-25 标 题 :Synthesis of 6-azido-6-deoxy-2-n-acetyl-hexosamine-nucleoside diphosphate 发明人:HOOGENBOOM JORIN; WIJDEVEN MARIA ANTONIA; VERKADE JORGE MERIJN MATHIEU; VAN DELFT FLORIS LOUIS; VAN BERKEL SANDER SEBASTIAAN 权利人:SYNAFFIX BV 摘要:The current invention concerns methods for the synthesis of 6-azido-6-deoxy-2-N-acetyl-monosaccharide-nucleoside diphosphate, in particular 6-azido-6-deoxy-2-N-acetyl-D-galactosamine-nucleoside diphosphate or 6-azido-6-deoxy-2-N-acetyl-D-glucosamine-nucleoside diphosphate. The synthesis method according to the invention is characterized by being highly efficient and high yielding. Also part of the present invention are key intermediates of this process.
专利号:US-2023286918-A1 优先权日:2020-07-02 标 题:Manufacturing process for 3,5-dichloropicolinonitrile for synthesis of vadadustat 发明人:JURKAUSKAS VALDAS; JUNG YOUNG CHUN; KWON TAESOO; KANNAN ARUNACHALAM; GONDI VIJAYA BHASKER 权利人:AKEBIA THERAPEUTICS INC 摘要:Disclosed herein are methods and processes of preparing vadadustat or a pharmaceutically acceptable salts thereof, and intermediates (e.g., a compound of Formula (I), (I-F), (II), or (IV), or a pharmaceutically acceptable salts thereof) useful for the synthesis of vadadustat.
参考文献:10.1371/journal.pone.0021387 摘要:Nam S, Chen X, Lim J, Kim SH, Kim S, Cho Y, Yoon J, Park S. In Vivo Fluorescence Imaging of Bacteriogenic Cyanide in the Lungs of Live Mice Infected with Cystic Fibrosis Pathogens. PLoS ONE. 2011 Jul 07;6(7):e21387. doi: 10.1371/journal.pone.0021387.