CAS: 37441-29-5; 5-Amino-2,4,6-Triiodoisophthaloyl Dichloride

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5-硝基异酞酸置于五氯化磷,一氯化碘体系中,化学反应 5.84H,反应生成 5-氨基-2,4,6-三碘异酞酰氯
参考文献:一种碘帕醇的合成及其合成中间体的制备
标题:一种碘帕醇的合成及其合成中间体的制备
摘要:本发明涉及化工合成工艺技术领域,尤其是一种碘帕醇的合成及其合成中间体的制备,本发明制备工艺通过调整投料重量比例,优化反应条件,改善碘帕醇的合成路线,对化合物反应的条件要求更低,对反应的控制十分简单,在提高收率的同时大大提高了中间体产品的质量,从而碘帕醇在生产过程中工艺控制的难度,提高了碘帕醇的质量和合格率,此制备工艺各步骤操作方法简单,溶剂及工艺条件安全易行,实现了环保绿色生产,具有广阔的应用前景.

专利信息

专利号:US-5817861-A
优先权日:1996-03-29
标题 :Process for the preparation of an intermediate useful in the synthesis of iodinated contrast media
发明人：VILLA MARCO; NARDI ANTONIO; PAIOCCHI MAURIZIO
权利人:BRACCO INT BV
摘要:A process for the preparation of (S)-N,N'-bis 2-hydroxy-1-(hydroxymethyl)ethyl!-5-(2-acetoxy-propionylamino)-2,4,6-triiodo-isophthalamide, an intermediate useful for the synthesis of iopamidol, by reaction between L-5-(2-acetoxy-propionylamino)-2,4,6-triiiodoisophthaloyl dichloride and 2-amino-1 ,3-propanediol in N-methylpyrrolidone and in the presence of a base, is described.

专利号:US-10836711-B2
优先权日:2017-02-10
标 题 :Method for the one-pot production of organo-iodinated compounds
发明人：PETTA MYRIAM; PELLINGHELLI STEPHAN
权利人:GUERBET SA
摘要:The present invention concerns a process for the preparation of organo-iodized compounds, as well as their preparation intermediates. More particularly, the present invention concerns a process for the preparation of organo-iodized compounds which can be used as preparation intermediates in the synthesis of iodized contrast agents.

专利号:US-6100425-A
优先权日:1996-12-24
标题:Process for the preparation of an intermediate useful in the synthesis of iodinated contrast media
发明人：VILLA MARCO; PAIOCCHI MAURIZIO
权利人:BRACCO INT BV
摘要:A process for the preparation of the compound L-5-(2-acetoxypropionylamino)-2,4,6-triiodoisophthaloyl dichloride by reacting 5-amino-2,4,6-triiodoisophthaloyl dichloride with L-2-acetoxypropionyl chloride in N,N-dimethylacetamide as a solvent, characterized in that a catalytic amount of a lower alcohol is added to the reaction mixture.

专利号:US-5663432-A
优先权日:1995-05-18
标 题:Process for the preparation of 5-amino-2,4,6-Triiodoisophthalic acid dichloride by chlorination with thionyl chloride in the presence of a catalyst
发明人：VILLA MARCO; POZZOLI CLAUDIO; RUSSO LAURA; CASTALDI GRAZIANO
权利人:ZAMBON SPA
摘要:A process for the preparation of 5-amino-2,4,6-triiodoisophthalic acid dichloride by chlorination of 5-amino-2,4,6-triiodoisophthalic acid with thionyl chloride in the presence of a suitable solvent characterized in that the reaction is carried out in the presence of catalytic amounts of a tetraalkylammonium salt of formula R1R2R3R4NX (I) wherein X is halogen, mesylate or tosylate; R1, R2, R3 and R4, the same or different, are C1-C20 alkyl groups so that the total number of carbon atoms of the groups R1, R2, R3 and R4 is higher than 16. The 5-amino-2,4,6-triiodoisophthalic acid dichloride obtained according to the process of the present invention is useful as intermediate in the synthesis of iodinated contrast media.

专利号:US-11472767-B2
优先权日:2018-08-02
标 题 :Process for the monotopic preparation of intermediate organo-iodinated compounds for the synthesis of ioversol
发明人：STÉPHAN PELLINGHELLI; PETTA MYRIAM
权利人:GUERBET SA
摘要:A process for preparing an organo-iodinated compound, comprising the following steps:a) acylating 2,4,6-triiodo-5-aminoisophthalic acid of formula (A) below:to obtain an intermediate compound Ya;b) chlorinating the intermediate compound Ya to obtain an organo-iodinated intermediate compound Yb;c) amidating the organo-iodinated intermediate compound Yb to obtain an intermediate compound Yc; andd) deprotecting the intermediate compound Yc, the steps a), b), c) and d) being carried out without isolation of at least one intermediate compound chosen from Ya and Yc.

专利号:US-10836710-B2
优先权日:2016-12-05
标 题 :Mechanochemical synthesis of radiographic agents intermediates
发明人：BARGE ALESSANDRO; BARICCO FRANCESCA; CRAVOTTO GIANCARLO; FRETTA ROBERTA; LATTUADA LUCIANO
权利人:BRACCO IMAGING SPA
摘要:The present invention generally relates to a process using a mechanochemical approach exploiting the mechanical milling of reactants for the manufacturing of acetyl Iopamidol and, more generally, of key intermediates of radiographic contrast agents, and of the contrast agents themselves.