CAS: 38557-71-0; 2-Chloro-6-Methylpyrazine

该化合物是一种杂交有机化合物,其特征为具有氯原子和2号和6号位置分别附着的甲基组,其分子式为C6H6ClN2, 具有含氮芳香结构,有助于其化学反应和潜在应用;该化合物一般无色可粉黄的黄色液体或固体,取决于其纯度和形态;它有一种独特的气味,经常被称为土质或芥子,可归因于其正子结构. 2-Chroloo-6-甲基双子素在有机溶剂中溶解,在水中溶解度有限,主要用于各种药品和农用化学品的合成,以及因其独特的芳香性特性而在调味和香味应用中使用.在处理该化合物时,应注意安全防范措施,因为若吸入或浸泡,可能会对健康造成危害.

英文名称2-Chloro-6-Methylpyrazine
中文名称2-氯-6-甲基吡嗪
IUPAC名称2-chloro-6-methylpyrazine
其它别名2-甲基-6-氯吡嗪; 2氯6甲基吡嗪; 6-Methyl-2-Chloropyrazine; 2-Chloro-6-Methylpyrazine
CAS编号38557-71-0
MFCD编号:MFCD00055032
EINECS号:690-445-2
分子式:C5H5ClN2
分子量:128.56
产品CID: 1397886
产品分类有机原料→分子砌块→芳杂环类化合物→吡嗪类化合物

相似结构搜索
产品信息参考;
InChIKey: CKUVSPQGYLELRG-UHFFFAOYSA-N
InChI=1S/C5H5ClN2/c1-4-2-7-3-5(6)8-4/h2-3H,1H3…
计算化学: 氢键受体数2.0氢键供体数0.0可旋转键数0.0

相似化合物

59303-10-5 32493-78-0 95-89-6

物理性质

熔点48-52°C
沸点173.6°C at 760 mmHg
闪点73.3±11.5 °C
密度1.2±0.1 g/cm3
pKa:-0.89±0.10(预测)
PSA:25.78
LogP:1.43842
折射率1.530
蒸汽压1.7±0.3 mmHg at 25°C
外观形态白色至几乎白色粉末至晶体
储存条件置于阴暗处,密封, 常温干燥保存
产品应用该化合物用于合成HCV NS5B聚合酶和强效二丁基乙酰四甲基抑制剂的棕榈地抑制剂.

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别皮肤腐蚀/刺激类别2
严重眼刺激类别2
急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
严重眼刺激类别2A
急性毒性类别3(吸入)
急性毒性类别3(经皮)
急性毒性类别3(经口)
警示词Warning(警告)
危险描述H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H331 |吸入会中毒.
H311 |皮肤接触会中毒.
H301 |吞咽会中毒.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
UN编号NONH for all modes of transport
危险品标志Xi,Xn
风险等级Irritant
安全声明22-26-36/37/39
危险类别码20/21/22-36/37/38-22
WGK Germany3

欧盟法规

ECHA物质C&L通报

上下游产品

4-methyl-1H-imidazole chloroform 2-Methylpyrazine 6-methylpyrazin-2-amine 2-methoxyl-6-methylpyrazine 6-methyl-2(1H)-pyrazinone 4-oxide 2-hydrazino-6-methylpyrazine

合成工艺路线路线简述

109-08-0 = 38557-71-0 + 95-58-9
反应条件:1.1 Reagents: Chlorine Solvents: Carbon Tetrachloride; 60 Min,-15 °C1.2 2 H,-15 °C -> Rt1.3 Reagents: Sodium Hydroxide Solvents: Water; Basified,Rt
标题:Convenient Synthesis Of Stable Deuterium-Labeled Alkylpyrazines For Use In Stable Isotope Dilution Assays
作者:Fang,Mingchih; Cadwallader,Keith R.
参考文献:Journal Of Agricultural And Food Chemistry 日期:2013 卷标:61(15) 页码:3580-3588

2-(6-氯吡嗪-2-基)丙二酸二甲酯盐酸盐置于水,Sodium Hydroxide体系中,用水用作溶剂,化学反应 36.0H,反应生成2-氯-6-甲基吡嗪
参考文献: Antidiabetic Bicyclic Compounds[fr] Composés Bicycliques Antidiabétiques
标题: Antidiabetic Bicyclic Compounds[fr] Composés Bicycliques Antidiabétiques
摘要:结构式(I)的新化合物及其药用盐是g蛋白偶联受体40(gpr40)的激动剂,可能在治疗,预防和抑制由g蛋白偶联受体40介导的疾病中有用.本发明的化合物可能在治疗2型糖尿病以及与该疾病经常相关的疾病,包括肥胖和脂质紊乱,如混合型或糖尿病性脂质异常,高脂血症,高胆固醇血症和高甘油三酯血症方面有用.

专利信息

专利号:US-8207337-B2
优先权日:2007-01-29
标题:Reagent for organic synthesis reaction containing organic triol borate salt
发明人：MIYAURA NORIO; YAMAMOTO YASUNORI
权利人:MIYAURA NORIO; YAMAMOTO YASUNORI; WAKO PURE CHEM IND LTD
摘要:[Problem] n To provide an organoboron compound-containing reagent for organic synthesis reactions which undergoes no trimerization with dehydration, does not necessitate activation with a base, and is stable and highly active. n [Means for Solving Problems] n The reagent for organic synthesis reactions contains an organic triol borate salt represented by any of the general formulae (I) to (III) and general formula (XVI): (wherein R 1 represents alkyl, alkenyl, etc.; R 2 represents optionally substituted alkyl, alkenyl, alkynyl, etc. or represents hydrogen; m + represents an alkaline metal ion, phosphonium ion, or given ammonium ion; M 2+ represents an alkaline earth metal; X represents halogen or alkoxide; Y represents an alkali metal ion, etc.; A represents optionally substituted methylene; and n represents an integer).

专利号:WO-2023114200-A2
优先权日:2021-12-14
标题 :Methods for the synthesis of complement factor d inhibitors and intermediates thereof

专利号:WO-2023114198-A2
优先权日:2021-12-15
标题 :Methods for the synthesis of complement factor d inhibitors