专利号:US-7250410-B2 优先权日:2001-06-07 标题:Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses thereof 发明人:BOURGUIGNON JEAN-JACQUES; LAGOUGE YAN; LUGNIER CLAIRE; KLOTZ EVELINE; MACHER JEAN-PAUL; RABOISSON PIERRE; SCHULTZ DOMINIQUE 权利人:VIA PHARMACEUTICALS INC 摘要:The invention concerns novel benzodiazepine derivatives and their uses in the field of therapeutics particularly for treating pathologies involving the activity of a cyclic nucleotide phosphodiesterase. It also concerns methods for preparing them and novel synthesis intermediates. The inventive compounds more particularly correspond to general formula (I):
专利号:EP-1556055-B1 优先权日:2002-10-30 标 题 :Cyclic nucleotide phosphodiesterase inhibitors having a benzodiazepine structure and their use in therapy 发明人:BOURGUIGNON JEAN-JACQUES; LUGNIER CLAIRE; ABARGHAZ MUSTAPHA; LAGOUGE YAN; WAGNER PATRICK; MONDADORI CESARE; MACHER JEAN-PAUL; SCHULTZ DOMINIQUE; RABOISSON PIERRE 权利人:VIA PHARMACEUTICALS INC 摘要:The invention concerns the use of PDE2 inhibitors for treating disorders of the central and peripheral nervous system, a method for therapeutic treatment by administering to an animal said inhibitors. More specifically, the invention concerns novel benzodiazepinone derivatives and their uses in therapeutics more particularly for treating pathologies involving activity of a cyclic nucleotide phosphodiesterase type 2. The invention also concerns methods for preparing same and novel synthesis intermediates.