3-{[(3-羧基苯基)硫烷基]磺酰}苯甲酸置于sodium Hydroxide,乙醇,Sodium Carbonate,4-甲苯硫酚体系中,化学反应生成 3-巯基苯甲酸 参考文献:Smiles; Gibson,Journal Of The Chemical Society,1924,Vol. 125,P. 181 标题:Smiles; Gibson,Journal Of The Chemical Society,1924,Vol. 125,P. 181
专利号:US-2003232952-A1 优先权日:2001-02-02 标题:Design and synthesis of instant - degradable plastics 发明人:ROSEN OREN 摘要:A novel class of instant degradable synthetic polymeric plastics having the characteristics and properties of conventional forms of plastics is developed by providing a new application advantage of incorporating latent, labile, dormant chemical bond nuclei such as disulfide and sulfenyl derivatives of the plastic compounds with latent nucleophilic properties. The special advantage of the instant degradable polymers over the existing biodegradable and other degradable polymer counterparts, is their engineering and design, which makes the kinetics of their degradation instant, and the chemical and physical properties of their by-products allows soluble dissolution into non-toxic aqueous solvent media, thus enabling a practical treatment of waste and avoiding bio-hazardous pollution of the environment. These novel plastic products are made from a variety of compositions of polymers and their compatible nontoxic modifiers. The resulting novel instant degradable plastic products retain latent dormant solubility properties that are triggered upon mild chemical reaction, thus enabling cost effective and facile recycling of plastic refuge.
专利号:US-2017304902-A1 优先权日:2016-04-22 标题:Synthesis of water-soluble thiolate-protected gold nanoparticles of uniform size and conjugates thereof 发明人:AZUBEL MAIA; KORNBERG ROGER D 权利人:UNIV LELAND STANFORD JUNIOR 摘要:Methods of synthesizing water-soluble thiolate-protected gold nanoparticles of uniform size and conjugates thereof are disclosed. In particular, the invention relates to a method of synthesizing homogeneous, water-soluble gold nanoparticles by using a modified Brust procedure and methods of conjugating them. Gold nanoparticles, produced by the methods of the invention, are useful in various therapeutic and imaging applications where the use of gold nanoparticles having uniform structural and optical properties is desired.
专利号:US-7674881-B2 优先权日:2005-10-07 标题:Convergent synthesis of proteins by kinetically controlled ligation 发明人:KENT STEPHEN; PENTELUTE BRAD; BANG DUHEE; JOHNSON ERIK; DUREK THOMAS 权利人:UNIV CHICAGO 摘要:The present invention concerns methods and compositions for synthesizing a polypeptide using kinetically controlled reactions involving fragments of the polypeptide for a fully convergent process. In more specific embodiments, a ligation involves reacting a first peptide having a protected cysteyl group at its N-terminal and a phenylthioester at its C-terminal with a second peptide having a cysteine residue at its N-termini and a thioester at its C-termini to form a ligation product. Subsequent reactions may involve deprotecting the cysteyl group of the resulting ligation product and/or converting the thioester into a thiophenylester.
专利号:US-8231848-B1 优先权日:2012-04-10 标题:One-pot synthesis of chalcopyrite-based semi-conductor nanoparticles 发明人:REN YUHANG; SUN CHIVIN; SHUM KAI 权利人:REN YUHANG; SUN CHIVIN; SHUM KAI; SUN HARMONICS LTD 摘要:Ternary and quaternary Chalcopyrite CuInxGa1-xSySe2-y (CIGS, where 0≰x and y≰1) nanoparticles were synthesized from molecular single source precursors (SSPs) by a one-pot reaction in a high boiling solvent using salt(s) (i.e. NaCl as by-product) as heat transfer agent via conventional convective heating method. The nanoparticles sizes were 1.8 nm to 5.2 nm as reaction temperatures were varied from 150° C. to 190° C. with very high-yield. Tunable nanoparticle size is achieved through manipulation of reaction temperature, reaction time, and precursor concentrations. In addition, the method developed in this study was scalable to achieve ultra-large quantities production of tetragonal and quaternary Chalcopyrite CIGS nanoparticles.
专利号:US-2023159678-A1 优先权日:2020-06-19 标题:Methods of polymerization with aromatic thiol initiators 发明人:BOWMAN CHRISTOPHER N; LOVE DILLON 权利人:UNIV COLORADO REGENTS 摘要:Provided herein are methods of using aryl thiols as photoinitiators. The thiol compounds are useful as oxygen insen-sitive photoinitiators for applications such as bulk polymerizations and for specialty polymer synthesis by preparing aromatic thiol functionalized macroinitiators.
专利号:WO-2022189846-A1 优先权日:2021-03-10 标 题:NOVEL ADENOSYLMERCAPTANE DERIVATIVES AS VIRAL mRNA CAP METHYLTRANSFERASE INHIBITORS 发明人:BOBILEVA OLGA; BOBROVS RAITIS; KANEPE IVETA; KALNINS GINTS; SISOVS MIHAILS; BULA ANNA LINA; JIRGENSONS AIGARS; TARS KASPARS; JAUDZEMS KRISTAPS 权利人:LATVIAN INST ORGANIC SYNTHESIS 摘要:The present invention relates to medicine, and in particular to the treatment of viral infections, more particularly to inhibitors of viral mRNA cap methyltransf erases (MTases). Even more particularly, the invention relates to adenosylmercaptane derivatives and pharmaceutical compositions thereof and their use as inhibitors for viral mRNA cap methyltransferases.
[参考文献]: Homan Kang, Et Al. Direct Identification Of On-Bead Peptides Using Surface-Enhanced Raman Spectroscopic Barcoding System For High-Throughput Bioanalysis. Sci Rep. 2015 May 28:5:10144. [参考文献]: Isabel Freitag, Et Al. Differentiation Of Mcf-7 Tumor Cells From Leukocytes And Fibroblast Cells Using Epithelial Cell Adhesion Molecule Targeted Multicore Surface-Enhanced Raman Spectroscopy Labels. J Biomed Opt. 2015 May;20(5):55002. [参考文献]: Leonora Velleman, Et Al. Raman Spectroscopy Probing Of Self-Assembled Monolayers Inside The Pores Of Gold Nanotube Membranes. Phys Chem Chem Phys. 2011 Nov 21;13(43):19587-93.
合成参考文献
摘要:J. P. Danehy and K. N. Parameswaran, J. Chem. Eng. Data 13, 386 (1968).