CAS: 4869-59-4; 3-Mercaptobenzoic Acid

该化合物是一种芳香色硫酸化合物,其特点是含有碳酸(-COOH)和苯环所附的硫醇(-SH)功能组,该化合物一般是白色的光黄色晶状固体,在水和酒精等极溶剂中溶解,但非冰溶剂中溶解性较少;硫醇组的存在具有不同的化学再活动性,允许其参与各种反应,包括氧化和核生殖替代. 3-Mercaptobenzoic酸在有机合成中的应用,特别是在金属硫酸化合物的准备和化学协调中的悬浮性方面,是已知的.此外,它显示出潜在的生物活动,对制药研究感兴趣.其特性,如熔点和沸点,可以因纯度和环境条件而有所不同,但一般在标准实验室条件下保持稳定.

结构式图片

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ECHA物质C&L通报REACH预注册

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CAS号4025-64-3 间氯磺酰基苯甲酸 | CAS号618-51-9 间碘苯甲酸 | CAS号1227-49-2 3,3'-二硫基二苯甲酸 | CAS号1012060-97-7 methyl 3-((etho... | CAS号65-85-0 苯甲酸 | CAS号140-89-6 乙基黄原酸钾 | CAS号99-05-8 间氨基苯甲酸 | CAS号535-80-8 间氯苯甲酸 | CAS号15451-00-0 3-亚磺基苯甲酸 | CAS号1234-18-0 Benzoic acid,3-... | CAS号825-99-0 3-(甲硫基)苯甲酸 | CAS号72886-42-1 3-巯基苯甲酸甲酯 | CAS号5345-27-7 3-甲砜基苯甲酸 | CAS号1227-49-2 3,3'-二硫基二苯甲酸 | CAS号1220052-19-6 2-formyl-8-hydr... | CAS号1075-49-6 4-乙烯基苯甲酸 | CAS号73771-35-4 3-(甲基硫代)苯甲醛 | CAS号668262-21-3 3-(pyridin-4-yl... | CAS号83794-86-9 3-疏基苄醇

合成工艺路线路线简述

    3-{[(3-羧基苯基)硫烷基]磺酰}苯甲酸置于sodium Hydroxide,乙醇,Sodium Carbonate,4-甲苯硫酚体系中,化学反应生成 3-巯基苯甲酸
    参考文献:Smiles; Gibson,Journal Of The Chemical Society,1924,Vol. 125,P. 181
    标题:Smiles; Gibson,Journal Of The Chemical Society,1924,Vol. 125,P. 181

    海关参考信息

    专利信息


    专利号:US-2003232952-A1
    优先权日:2001-02-02
    标题:Design and synthesis of instant - degradable plastics
    发明人:ROSEN OREN
    摘要:A novel class of instant degradable synthetic polymeric plastics having the characteristics and properties of conventional forms of plastics is developed by providing a new application advantage of incorporating latent, labile, dormant chemical bond nuclei such as disulfide and sulfenyl derivatives of the plastic compounds with latent nucleophilic properties. The special advantage of the instant degradable polymers over the existing biodegradable and other degradable polymer counterparts, is their engineering and design, which makes the kinetics of their degradation instant, and the chemical and physical properties of their by-products allows soluble dissolution into non-toxic aqueous solvent media, thus enabling a practical treatment of waste and avoiding bio-hazardous pollution of the environment. These novel plastic products are made from a variety of compositions of polymers and their compatible nontoxic modifiers. The resulting novel instant degradable plastic products retain latent dormant solubility properties that are triggered upon mild chemical reaction, thus enabling cost effective and facile recycling of plastic refuge.

    专利号:US-2017304902-A1
    优先权日:2016-04-22
    标题:Synthesis of water-soluble thiolate-protected gold nanoparticles of uniform size and conjugates thereof
    发明人:AZUBEL MAIA; KORNBERG ROGER D
    权利人:UNIV LELAND STANFORD JUNIOR
    摘要:Methods of synthesizing water-soluble thiolate-protected gold nanoparticles of uniform size and conjugates thereof are disclosed. In particular, the invention relates to a method of synthesizing homogeneous, water-soluble gold nanoparticles by using a modified Brust procedure and methods of conjugating them. Gold nanoparticles, produced by the methods of the invention, are useful in various therapeutic and imaging applications where the use of gold nanoparticles having uniform structural and optical properties is desired.

    专利号:US-7674881-B2
    优先权日:2005-10-07
    标题:Convergent synthesis of proteins by kinetically controlled ligation
    发明人:KENT STEPHEN; PENTELUTE BRAD; BANG DUHEE; JOHNSON ERIK; DUREK THOMAS
    权利人:UNIV CHICAGO
    摘要:The present invention concerns methods and compositions for synthesizing a polypeptide using kinetically controlled reactions involving fragments of the polypeptide for a fully convergent process. In more specific embodiments, a ligation involves reacting a first peptide having a protected cysteyl group at its N-terminal and a phenylthioester at its C-terminal with a second peptide having a cysteine residue at its N-termini and a thioester at its C-termini to form a ligation product. Subsequent reactions may involve deprotecting the cysteyl group of the resulting ligation product and/or converting the thioester into a thiophenylester.

    专利号:US-8231848-B1
    优先权日:2012-04-10
    标题:One-pot synthesis of chalcopyrite-based semi-conductor nanoparticles
    发明人:REN YUHANG; SUN CHIVIN; SHUM KAI
    权利人:REN YUHANG; SUN CHIVIN; SHUM KAI; SUN HARMONICS LTD
    摘要:Ternary and quaternary Chalcopyrite CuInxGa1-xSySe2-y (CIGS, where 0≰x and y≰1) nanoparticles were synthesized from molecular single source precursors (SSPs) by a one-pot reaction in a high boiling solvent using salt(s) (i.e. NaCl as by-product) as heat transfer agent via conventional convective heating method. The nanoparticles sizes were 1.8 nm to 5.2 nm as reaction temperatures were varied from 150° C. to 190° C. with very high-yield. Tunable nanoparticle size is achieved through manipulation of reaction temperature, reaction time, and precursor concentrations. In addition, the method developed in this study was scalable to achieve ultra-large quantities production of tetragonal and quaternary Chalcopyrite CIGS nanoparticles.

    专利号:US-2023159678-A1
    优先权日:2020-06-19
    标题:Methods of polymerization with aromatic thiol initiators
    发明人:BOWMAN CHRISTOPHER N; LOVE DILLON
    权利人:UNIV COLORADO REGENTS
    摘要:Provided herein are methods of using aryl thiols as photoinitiators. The thiol compounds are useful as oxygen insen-sitive photoinitiators for applications such as bulk polymerizations and for specialty polymer synthesis by preparing aromatic thiol functionalized macroinitiators.

    专利号:WO-2022189846-A1
    优先权日:2021-03-10
    标 题:NOVEL ADENOSYLMERCAPTANE DERIVATIVES AS VIRAL mRNA CAP METHYLTRANSFERASE INHIBITORS
    发明人:BOBILEVA OLGA; BOBROVS RAITIS; KANEPE IVETA; KALNINS GINTS; SISOVS MIHAILS; BULA ANNA LINA; JIRGENSONS AIGARS; TARS KASPARS; JAUDZEMS KRISTAPS
    权利人:LATVIAN INST ORGANIC SYNTHESIS
    摘要:The present invention relates to medicine, and in particular to the treatment of viral infections, more particularly to inhibitors of viral mRNA cap methyltransf erases (MTases). Even more particularly, the invention relates to adenosylmercaptane derivatives and pharmaceutical compositions thereof and their use as inhibitors for viral mRNA cap methyltransferases.
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    主要参考文献

    [参考文献]: Homan Kang, Et Al. Direct Identification Of On-Bead Peptides Using Surface-Enhanced Raman Spectroscopic Barcoding System For High-Throughput Bioanalysis. Sci Rep. 2015 May 28:5:10144.
    [参考文献]: Isabel Freitag, Et Al. Differentiation Of Mcf-7 Tumor Cells From Leukocytes And Fibroblast Cells Using Epithelial Cell Adhesion Molecule Targeted Multicore Surface-Enhanced Raman Spectroscopy Labels. J Biomed Opt. 2015 May;20(5):55002.
    [参考文献]: Leonora Velleman, Et Al. Raman Spectroscopy Probing Of Self-Assembled Monolayers Inside The Pores Of Gold Nanotube Membranes. Phys Chem Chem Phys. 2011 Nov 21;13(43):19587-93.

    合成参考文献


    摘要:J. P. Danehy and K. N. Parameswaran, J. Chem. Eng. Data 13, 386 (1968).
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