CAS: 50-85-1; 2-Hydroxy-4-Methylbenzoic Acid

上下游产品

CAS号99-94-5 对甲基苯甲酸 | CAS号7697-25-8 2-氯-4-甲基苯甲酸 | CAS号124-38-9 二氧化碳 | CAS号108-39-4 间甲酚 | CAS号298-14-6 碳酸氢钾 | CAS号5331-40-8 Pyridinium,1-[2... | CAS号6921-64-8 2'-羟基-4'-甲基苯乙酮 | CAS号71321-26-1 2-hydroxy-2-(2-... | CAS号14002-90-5 4,7-二甲基香豆素 | CAS号698-27-1 2-羟基-4-甲基苯甲醛 | CAS号4670-56-8 4-甲基水杨酸甲酯 | CAS号14504-07-5 2-乙酰氧基-4-甲基苯甲酸 | CAS号4619-74-3 2,4,6-三溴-3-甲基苯酚 | CAS号29666-53-3 2,5-Cyclohexadi... | CAS号6623-35-4 5-溴-2-羟基-4-甲基苯甲酸 | CAS号6623-36-5 3,5-二溴-2-羟基-4-甲基苯甲酸 | CAS号19814-69-8 3,6-dimethylxan... | CAS号220438-80-2 (4-羧基-2-乙氧基-苯基)-乙酸 | CAS号108-39-4 间甲酚 | CAS号124-38-9 二氧化碳

2-氯-4-甲基苯甲酸置于trans-N,N'-Dimethyl-1,2-Cyclohexyldiamine,Copper(I) Bromide Calcium Hydroxide,水,盐酸体系中,用 水 作为反应溶剂,化学反应 25.0H,以95%的收率获得产物4-甲基水杨酸
参考文献:Process For The Synthesis Of Hydroxy Aromatic Acids
标题:Process For The Synthesis Of Hydroxy Aromatic Acids
摘要:羟基芳香酸在含有铜源和与铜配位的配体的反应混合物中,从卤化芳香酸中高产量高纯度(>95%)地生产.

专利信息

专利号:US-6686497-B1
优先权日:1999-11-16
标题:Synthesis of 3-ethoxy-4-ethoxycarbonyl phenyl acetic acid, a key acid synthon of repaglinide
发明人：SALMAN MOHAMMAD; BABU J SURESH; RAY PURNA C; BISWAS SUJAY; KUMAR NARESH
权利人:RANBAXY LAB LTD
摘要:The present invention relates to a new and industrially advantageous process for the preparation of 3-ethoxy-4-ethoxy-carbonyl-phenyl acetic acid. This compound is a key intermediate for the synthesis of Repaglinide, an oral hypoglycemic agent.

专利号:US-6180830-B1
优先权日:1995-11-08
标题 :Method for preparing a bimetallic ruthenium/tin catalyst and a process for the synthesis of aldehydes
发明人：JACQUOT ROLAND
权利人:RHODIA CHIMIE SA
摘要:The present invention relates to a new process for the preparation of a bimetallic ruthenium/tin catalyst. The process for the preparation of a bimetallic ruthenium/tin catalyst according to the invention is characterised by the fact that it consists in carrying out the reduction of a ruthenium complex having an electrovalency of -4 and a coordination number of 6, the ligands being either a halogen atom or an anion or a tin halide. The catalyst is further employed for the preparation of aldehydes by reduction, in the vapor phase, of carboxylic acids, esters and anhydrides.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:WO-2024054881-A1
优先权日:2022-09-07
标题:Ligand-enabled scalable c-h hydroxylation of benzoic and phenylacetic acids at room temperature
发明人：YU JIN-QUAN; LI ZHEN; PARK HAN
权利人:SCRIPPS RESEARCH INST
摘要:The application discloses industry scalable methods of using bifunctional bidentate pyridone-carboxylic acid ligands, such as 2-methyl-2-(6-oxo-1,6-dihydropyridin-2-yl)propanoic acid, that enable room-temperature Pd-catalyzed C-H hydroxylation of a broad range of benzoic and phenylacetic acids with an industry-compatible oxidant, aqueous hydrogen peroxide, at room temperature. Further disclosed are methods of derivatization of the resulting hydroxylation products, synthesis of polyfluorinated natural products coumestan or pterocarpene from phenol building blocks, and hydroxylation of ibuprofen using this methodology,

专利号:US-6818786-B2
优先权日:2003-03-31
标题 :Process for the preparation of ethyl 3-ethoxy-4-ethoxycarbonyl-phenylacetate
发明人：KALKOTE UTTAM R; GURJAR MUKUND K; JOSHI SHREERANG V; KADAM SURESH M; NAIK SANJAY J
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to a process for the preparation of ethyl 3-ethoxy-4-ethoxycarbonyl-phenylacetate having formula 1Ethyl 3-ethoxy-4-ethoxycarbonyl-phenylacetate (1) is an important key intermediate for the synthesis of repaglinide (2) an oral hypoglycemic agent

专利号:US-8889863-B2
优先权日:2010-07-16
标题:Stereoselective methods, catalysts and intermediates for the synthesis of (−)-Nutlin-3 and related compounds
发明人：JOHNSTON JEFFREY N; DAVIS TYLER A
权利人:JOHNSTON JEFFREY N; DAVIS TYLER A; UNIV VANDERBILT
摘要:The present invention provides methods and intermediates are provided for the preparation of (−)-Nutlin-3. Methods and intermediates are also provided for the enantioselective addition of aryl nitromethanes to aldimines. Bis(amidine) catalysts for the use in these and other reactions are also provided.