CAS: 53475-15-3; 3-(Methylthio)Butan-2-One

相似化合物

40789-98-8 67633-97-0 161528-03-6

上下游产品

3-mercapto-2-butanone dimethyl sulfate 3-bromo-butanone sodium thiomethoxide

Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于sodium Hydroxide体系中,化学反应生成 3-甲巯基-2-丁酮
参考文献:Boehme; Heller,Chemische Berichte,1953,Vol. 86,P. 443,448
标题:Boehme; Heller,Chemische Berichte,1953,Vol. 86,P. 443,448

专利信息

专利号:US-3992392-A
优先权日:1973-04-27
标题:Synthesis of indoles from anilines and intermediates therein
发明人：GASSMAN PAUL G
权利人:UNIV OHIO STATE RES FOUND
摘要:Preparing indoles and intermediates therefor by reacting an N-haloaniline with a β-carbonylic hydrocarbon sulfide to form an azasulfonium halide, reacting the azasulfonium halide with a strong base to form a thio-ether indole derivative, and then reducing the thio-ether indole, e.g. with Raney nickel, to form the indole compound. When an acetal or ketal of the β-carbonyl hydrocarbon sulfide is used, the azasulfonium salt is treated with a base, and then with an acid to form the thio-ether indole derivative. When an α-ethyl-β -carbonylic hydrocarbon sulfide is used, the resulting azosulfonium salt reacts with strong base to form a thio-ether indolenine derivative, which on reduction with Raney nickel or complex metal hydrides yields 3-substituted indoles. The aniline may be an aminopyridine to form an aza-indole compound in the process. The azasulfonium salts and thio-ether indole or thio-ether indolenine derivatives can be isolated and recovered from their respective reaction mixtures. The thio-ether-indole and thio-ether indolenine derivatives are useful as intermediates to make the indoles without the thio-ether group. The indoles are known compounds having a wide variety of uses, e.g., in making perfumes, dyes, amino acids, pharmaceuticals, agricultural chemicals and the like.

专利号:CA-1043337-A
优先权日:1973-04-27
标题 :Synthesis of indoles from anilines and intermediates therein